Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (2): 133-136.doi: 10.7518/gjkq.2014.02.003

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Transplantation of vascular endothelial growth factor gene-modified bone mesenchymal stem cells into irradiated tissue

Wang Tao1, Liao Tian’an1, Wang Hong1, Deng Wei1, Yu Dahai2.   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Hainan Provincial Hospital, Haikou 570311, China; 2. Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital, Guangxi Medical University, Nanning 530021, China
  • Received:2013-05-13 Revised:2013-12-31 Online:2014-03-01 Published:2014-03-01

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Abstract:

Objective This study aimed to resume the ability of revascularization of the irradiated tissue by implantation of vascular endothelial growth factor(VEGF)-modified bone mesenchymal stromal cell(BMSC). Methods Each mouse was irradiated with 60Coγ ray on their right leg. The irradiated muscular tissues of the animal models were injected with VEGF165-modified BMSCs, and a second dose was administered after two weeks. We determined the expression of VEGF165 mRNA, VEGF165 protein, and ultrastructure of the vessels and nerves after gene therapy. Results VEGF165 mRNA and VEGF165 protein had high levels of expression in the irradiated tissue after the injection of VEGF165 -modified BMSCs. The configuration and ultrastructure of the vessels and nerves returned to normal. Conclusion VEGF165-modified BMSCs can resume the ability of the vessels and nerves of an irradiated tissue. This study provides abasis for the clinical application of VEGF165-modified BMSCs.

Key words: bone mesenchymal stem cell, vascular endothelial growth factor, irradiated injury

CLC Number: 

  • R 782

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