Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (6): 795-798.doi: 10.7518/gjkq.2013.06.025

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Relationship among SH3PXD2b gene, craniofacial dysmorphology, and otitis media

Yang Bin1,2, Zhang Zhiguang1   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China; 2. Dept. of Oral and Maxillofacial Surgery, The Affiliated Beijing Stomatological Hospital of Capital Medical University, Beijing 100050, China
  • Received:2013-04-16 Revised:2013-08-19 Online:2013-11-01 Published:2013-11-01

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Abstract:

Congenital craniofacial dysmorphology is a common disease in oral and maxillofacial surgery that is mainly caused by gene mutation. This disease affects the morphology and function of craniofacial organs. It usually is accompanied by eustachian tube dysfunction and otitis media, which cause hearing impairment. The SH3PXD2b gene is a newly discovered podosome adaptor protein that significantly affects podosome formation, extracellular matrix remodeling, and craniofacial organ development. This article reviews the SH3PXD2b gene, SH3PXD2b gene mutation, and its relationship with craniofacial dysmorphology and otitis media.

Key words: srchomology 3 and phox homology domain-containing adaptor protein 2b gene, gene mutation, craniofacial dysmorphology, eustachian tube dysfunction, otitis media

CLC Number: 

  • R 782

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