Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (4): 467-469.doi: 10.3969/j.issn.1673-5749.2010.04.026

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Surgical-induced animal models of lip and palate cleft

XU Yue, CHEN Zhen-qi, QIAN Yu-fen.   

  1. （Dept. of Orthodontics, The Ninth People′s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China）
  • Online:2010-07-20 Published:2010-07-20

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Abstract: The surgical-induced animal models are always used as experimental animals in the research of clinical therapeutics of lip and palate cleft disease. Choosing appropriate animal model is important for obtaining a reliable result which can be applicable to human beings. The present paper introduced and classified several surgical- induced animal models of lip and palate cleft as critical size defect, such as primate animal, rat, cat, dog, and rabbit, listed the methods of operation to create a lip and palate cleft model, the advantages and disadvantages, the principles of choosing an appropriate animal model, which helped the researchers to choose the experimental animal more targeted.

Key words: lip and palate cleft, animal model, surgical-induced


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