Abstract: Raf kinase inhibitory protein（RKIP） that serve as endogenous modulators of mitogen- activated protein kinase（MAPK） signaling pathway, have been demonstrated to play an increasingly important role in growth and differentiation in organisms. RKIP is a highly conserved, ubiquitously expressed protein. RKIP is identified as playing a role in MAPK cascade, and identification of the mechanism by which it regulates Raf- 1 activatio