Abstract: Objective To observe clinical effects of treating severe periodontal disease by flap curettaging plus implanting biological artificial material（BAM） artificial bone and flap curettage in two years. Methods 89 teeth with severe periodontal disease from 62 patients were divided into two groups. Group A was treated with flap curettage plus implanting BAM artificial bone into periodontal bone defective area. Group B was treated by flap curettage only. Clinical effects of all teeth in two groups were observed through examining periodontal indexes and taking X-ray after treated for 1 and 2 years. Results Partial periodontal indexes of all treated teeth in two groups had been improved after treated in 6 months. Clinical effects of group A are better than group B after treated for 2 years. Conclusion Clinical effects of treating severe periodontal disease by flap curettage plus planting BAM artificial bone into periodontal bone detective areas are superior than periodontal flap curettage only according to our clinical study.