国际口腔医学杂志 ›› 2013, Vol. 40 ›› Issue (4): 447-450.doi: 10.7518/gjkq.2013.04.008

• 论著 • 上一篇    下一篇

超声介导下的细针穿刺活检在腮腺肿瘤中的诊断价值的系统评价和Meta分析

门乙 李春洁 李龙江 韩波 夏辉 高宁   

  1. 口腔疾病研究国家重点实验室 华西口腔医院(四川大学) 成都 610041
  • 收稿日期:2012-12-17 修回日期:2013-02-22 出版日期:2013-07-01 发布日期:2013-07-01
  • 通讯作者: 李龙江, Tel: 028-85501428
  • 作者简介:门乙(1987—), 男, 四川人, 博士

Systematic review and Meta -analysis of ultrasonography guided fine -needle aspiration cytology for parotid tumors

Men Yi, Li Chunjie, Li Longjiang, Han Bo, Xia Hui, Gao Ning.   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2012-12-17 Revised:2013-02-22 Online:2013-07-01 Published:2013-07-01

摘要:

目的 评价超声介导下细针穿刺活检(USFNA)在腮腺肿瘤术前诊断中的价值。方法 检索中国生物医学文献库、Medline、Embase, 收集相关文献, 使用诊断性试验质量评价标准对文献质量进行评价。使用MetaDisc 1.4进行Meta分析。结果 10篇文献符合纳入标准。Meta分析结果显示, USFNA分辨腮腺肿瘤良恶性的合并诊断指标及其95%可信区间(95%CI)如下: 特异度0.99, 95%CI(0.98, 1.00); 敏感度0.86, 95%CI(0.78,0.91); 阳性似然比42.39, 95%CI(22.03, 81.57); 阴性似然比0.20, 95%CI(0.13, 0.29); 受试者工作曲线下面积0.983 0。结论 USFNA在腮腺肿瘤的良恶性鉴别中具有较高的特异度和敏感度, 可作为常规术前检查之一。

关键词: 腮腺肿瘤, 超声介导下的细针穿刺活检, 敏感度, 特异度

Abstract:

Objective To evaluate the diagnostic value of ultrasound-guided fine-needle aspiration(USFNA) in differentiating malignancy and benign lesions of the parotid gland. Methods The diagnostic studies on ultrasonography guided fine-needle aspiration cytology for parotid tumors were searched through Chinese biomedical literature database, Medline and Embase. The methodological quality was assessed with quality assessment of diagnostic accuracy studies. Two reviewers took part in all of the work in duplicate and any disagreement was resolved by discussion. Meta-analysis was done with MetaDisc 1.4. Results A total of 10 studies were included. The results of meta-analysis showed the pooled diagnostic values and its 95% confidence interval(95%CI) in differentiating malignant and benign tumors in the parotid gland as following: Specificity 0.99, 95%CI(0.98, 1.00); sensitivity 0.86, 95%CI(0.78, 0.91); positive likelihood ratio 42.39, 95%CI(22.03, 81.57); negative likelihood ratio 0.20, 95%CI(0.13, 0.29); the area beneath the receiver operating characteristic curve was 0.983 0. Conclusion The ultrasonography guided fine-needle aspiration cytology showed a high specificity and sensitivity in differencing the malignant and benign tumor of the parotid region, which should be used as a routine test before operation.

Key words: parotid gland neoplasms, ultrasound-guided fine-needle aspiration, sensitivity, specificity

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