国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (1): 58-63.doi: 10.7518/gjkq.2021007

• 综述 • 上一篇    下一篇

脂联素对骨髓间充质干细胞的作用及其调控机制

陈野,周丰,邬琼辉,车会凌,李佳璇,申佳琪,罗恩()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院 成都 610041
  • 收稿日期:2020-04-12 修回日期:2020-09-03 出版日期:2021-01-01 发布日期:2021-01-20
  • 通讯作者: 罗恩
  • 作者简介:陈野,学士,Email: <email>1450234528@qq.com</email>
  • 基金资助:
    国家自然科学基金(81970917)

Effect of adiponectin on bone marrow mesenchymal stem cells and its regulatory mechanisms

Chen Ye,Zhou Feng,Wu Qionghui,Che Huiling,Li Jiaxuan,Shen Jiaqi,Luo En()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-04-12 Revised:2020-09-03 Online:2021-01-01 Published:2021-01-20
  • Contact: En Luo
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81970917).(81970917)

摘要:

骨髓间充质干细胞(BMSCs)是治疗颅颌面骨疾病的研究热点,BMSCs在增殖、分化、迁徙方面的功能以及在组织环境中的存活能力决定了其骨质修复重建的质量和速度。脂联素(APN)是一种主要由脂肪组织分泌的脂肪因子,除了与脂代谢密切相关,近年来研究发现其还能通过多种途径调控BMSCs而影响成骨作用的进程,对骨—脂代谢平衡具有重要的调节作用。本文对APN的生物学特性、APN调控BMSCs增殖、成骨分化、迁徙和存活能力的作用以及相关信号通路的研究进展作一综述,为骨质疏松等骨相关疾病的预防和治疗提供新思路。

关键词: 脂联素, 骨髓间充质干细胞, 成骨作用

Abstract:

Bone marrow mesenchymal stem cells (BMSCs) are a research hotspot for the treatment of cranio-maxillofacial bone diseases. The function of BMSCs with regard to proliferation, differentiation, migration and survival ability in the tissue environment determines the quality and speed of bone repair and reconstruction. Adiponectin (APN) is an adipokine factor secreted primarily by adipose tissue. Apart from being closely related to lipid metabolism, APN can also affect the process of osteogenesis by regulating the function of BMSCs in a variety of ways, which plays an important role in regulating the balance of bone-lipid metabolism. In the article, the biological characteristics of APN and role of APN in regulating the proliferation, osteogenic differentiation, migration and survival ability of BMSCs and related signalling pathways are reviewed to provide new ideas for the prevention and treatment of bone-related diseases such as osteoporosis.

Key words: adiponectin, bone marrow mesenchymal stem cells, osteogenesis

中图分类号: 

  • R336
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