国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (4): 463-468.doi: 10.7518/gjkq.2019058

• 综述 • 上一篇    下一篇

灼口综合征唾液因素的研究进展

孟璐璐1,杜晓红2,武云霞1,2()   

  1. 1. 山西医科大学口腔医学院·口腔医院 太原 030001;
    2. 山西医科大学第一医院口腔科 太原 030001
  • 收稿日期:2018-09-19 修回日期:2019-02-05 出版日期:2019-07-01 发布日期:2019-07-12
  • 作者简介:孟璐璐,硕士,Email： 835490903@qq.com

Research progress on salivary factors in burning mouth syndrome

Meng Lulu1,Du Xiaohong2,Wu Yunxia1,2()   

  1. 1. School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Dept. of Stomatology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2018-09-19 Revised:2019-02-05 Online:2019-07-01 Published:2019-07-12

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摘要：

灼口综合征（BMS）是以舌部为主要发病部位、以烧灼样疼痛为主要表现的一组综合征,常不伴有明显的临床及病理损害。目前BMS病因尚不明确,其中唾液流量和成分改变对BMS影响的研究不断增多,本文就近年来国内外对唾液因素在BMS中的研究进展作一综述。

关键词: 灼口综合征, 唾液流量, 唾液成分

Abstract:

Burning mouth syndrome (BMS) is a group of syndromes that mainly occur in the tongue. This syndrome is characterized by burning pain without visible clinical signs and histopathological changes. The etiology of BMS remains unclear. The effects of changes in saliva flow and components on BMS are increasingly being investigated. This review introduces recent research progress from local and international BMS studies regarding salivary factors.

Key words: burning mouth syndrome, salivary flow, salivary components

中图分类号: 

  • R781.5
[1] 陈谦明 . 口腔黏膜病学[M]. 4版. 北京: 人民卫生出版社, 2012: 165-167.
Chen QM. Oral medicine[M]. 4th ed. Beijing: People’s Medical Publishing House, 2012: 165-167.
[2] Vellappally S . Burning mouth syndrome: a review of the etiopathologic factors and management[J]. J Contemp Dent Pract, 2016,17(2):171-176.
[3] Gurvits GE, Tan A . Burning mouth syndrome[J]. World J Gastroenterol, 2013,19(5):665-672.
[4] 尹茜, 孙正 . 灼口综合征的研究进展[J]. 国际口腔医学杂志, 2018,45(2):150-154.
Yin X, Sun Z . Research progress on burning mouth syndrome[J]. Int J Stomatol, 2018,45(2):150-154.
[5] Yoo HS, Jin SH, Lee YJ , et al. The role of psychological factors in the development of burning mouth syndrome[J]. Int J Oral Maxillofac Surg, 2018,47(3):374-378.
[6] 刘林林, 苏文君, 蒋春雷 . 唾液应激生理指标研究进展[J]. 临床军医杂志, 2017,45(11):1204-1208.
Liu LL, Su WJ, Jiang CL . Research progress on physiological indicators of saliva stress[J]. Clin J Med Offic, 2017,45(11):1204-1208.
[7] Aqrawi LA, Galtung HK, Vestad B , et al. Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis[J]. Arthritis Res Ther, 2017,19(1):14.
[8] Nasri-Heir C, Zagury JG, Thomas D , et al. Burning mouth syndrome: current concepts[J]. J Indian Prosthodont Soc, 2015,15(4):300-307.
[9] Imura H, Shimada M, Yamazaki Y , et al. Characteristic changes of saliva and taste in burning mouth syndrome patients[J]. J Oral Pathol Med, 2016,45(3):231-236.
[10] Poon R, Su N, Ching V , et al. Reduction in unstimulated salivary flow rate in burning mouth syndrome[J]. Br Dent J, 2014,217(7):E14.
[11] Spadari F, Venesia P, Azzi L , et al. Low basal salivary flow and burning mouth syndrome: new evidence in this enigmatic pathology[J]. J Oral Pathol Med, 2015,44(3):229-233.
[12] Kim MJ, Kim J, Kho HS . Comparison between burning mouth syndrome patients with and without psychological problems[J]. Int J Oral Maxillofac Surg, 2018,47(7):879-887.
[13] 木冬冬, 苏莎, 金建秋 , 等. 灼口综合征口干症状与焦虑抑郁症状的病例对照研究[J]. 中国心理卫生杂志, 2016,30(4):253-257.
Mu DD, Su S, Jin JQ , et al. A case-control study of re-lation of xerostomia to anxiety and depression symptoms in patients with burning mouth syndrome[J]. Chin Mental Health J, 2016,30(4):253-257.
[14] Pekiner FN, Gümrü B, Demirel GY , et al. Burning mouth syndrome and saliva: detection of salivary trace elements and cytokines[J]. J Oral Pathol Med, 2009,38(3):269-275.
[15] Henkin RI, Gouliouk V, Fordyce A . Distinguishing patients with glossopyrosis from those with oropyrosis based upon clinical differences and differences in saliva and erythrocyte magnesium[J]. Arch Oral Biol, 2012,57(2):205-210.
doi: 10.1016/j.archoralbio.2011.08.010
[16] López-Jornet P, Juan H, Alvaro PF . Mineral and trace element analysis of saliva from patients with BMS: a cross-sectional prospective controlled clinical study[J]. J Oral Pathol Med, 2014,43(2):111-116.
[17] Nosratzehi T, Salimi S, Parvaee A . Comparison of salivary cortisol and α-amylase levels and psychological profiles in patients with burning mouth syndrome[J]. Spec Care Dentist, 2017,37(3):120-125.
[18] Sharpley CF, Christie DRH, Bitsika V , et al. The use of salivary cortisol as an index of chronic stress that correlates with depression in prostate cancer patients[J]. Psychooncology, 2017,26(9):1400-1402.
[19] 苏莎, 刘宏伟, 黄悦勤 , 等. 灼口综合征与焦虑抑郁症状的病例对照研究[J]. 中国心理卫生杂志, 2015,29(10):750-754.
Su S, Liu HW, Huang YQ , et al. A case-control study of burning mouth syndrome and symptoms of anxiety and depression[J]. Chin Mental Health J, 2015,29(10):750-754.
[20] Amenábar JM, Pawlowski J, Hilgert JB , et al. Anxiety and salivary cortisol levels in patients with burning mouth syndrome: case-control study[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2008,105(4):460-465.
[21] Kim HI, Kim YY, Chang JY , et al. Salivary cortisol, 17β-estradiol, progesterone, dehydroepiandrosterone, and α-amylase in patients with burning mouth syndrome[J]. Oral Dis, 2012,18(6):613-620.
doi: 10.1111/j.1601-0825.2012.01937.x
[22] 侯海玲, 杨宗萍 . 绝经期妇女灼口综合征唾液免疫球蛋白的研究[J]. 实用口腔医学杂志, 2000,16(3):221-222.
Hou HL, Yang ZP . Immunoglobulin in the saliva of menopausal women with burning mouth syndrome[J]. J Pract Stomatol, 2000,16(3):221-222.
[23] 李寒, 张玉玮, 杨靖 . 唾液中SIgA与TMD患者心理因素的相关关系[J]. 重庆医学, 2013,42(15):1761-1763.
Li H, Zhang YW, Yang J . Correlation between psychological factors of SIgA and TMD in saliva[J]. Chongqing Med, 2013,42(15):1761-1763.
[24] Gibbins HL, Proctor GB, Yakubov GE , et al. SIgA binding to mucosal surfaces is mediated by mucin-mucin interactions[J]. PLoS One, 2015,10(3):e0119677.
[25] Kullaa AM, Asikainen P, Herrala M , et al. Microstructure of oral epithelial cells as an underlying basis for salivary mucosal pellicle[J]. Ultrastruct Pathol, 2014,38(6):382-386.
doi: 10.3109/01913123.2014.944732
[26] Kho HS, Chang JY, Kim YY , et al. MUC1 and Toll-like receptor-2 expression in burning mouth syndrome and oral lichen planus[J]. Arch Oral Biol, 2013,58(7):837-842.
doi: 10.1016/j.archoralbio.2013.01.008
[27] Kang JH, Kim YY, Chang JY , et al. Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome[J]. Arch Oral Biol, 2017,78:58-64.
[28] Pezelj-Ribarić S, Kqiku L, Brumini G , et al. Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low-level laser therapy[J]. Lasers Med Sci, 2013,28(1):297-301.
[29] de Souza FT, Kummer A, Silva ML , et al. The association of openness personality trait with stress-related salivary biomarkers in burning mouth syndrome[J]. Neuroimmunomodulation, 2015,22(4):250-255.
[30] Mathew PG, Dun EC, Luo JJ . A cyclic pain: the pathophysiology and treatment of menstrual migraine[J]. Obstet Gynecol Surv, 2013,68(2):130-140.
doi: 10.1097/OGX.0b013e31827f2496
[31] Nagel MA, Choe A, Traktinskiy I , et al. Burning mouth syndrome due to herpes simplex virus type 1[J]. BMJ Case Rep, 2015, 2015: bcr2015209488.
[32] Nagel MA, Gilden D . Burning mouth syndrome associated with varicella zoster virus[J]. BMJ Case Rep, 2016, 2016: bcr2016215953.
[33] 王妍婷 . 灼口综合征相关病因的评估与分析[D]. 南京: 南京医科大学, 2017.
Wang YT . The assessment and analysis of etiological factors involved in patients with burning mouth syndrome[D]. Nanjing: Nanjing Medical University, 2017.
[34] Brailo V, Vuéiaeeviae-Boras V, Alajbeg IZ , et al. Oral burning symptoms and burning mouth syndrome-significance of different variables in 150 patients[J]. Med Oral Patol Oral Cir Bucal, 2006,11(3):E252-E255.
[35] Gall-Troselj K, Mravak-Stipetić M, Jurak I , et al. Helicobacter pylori colonization of tongue mucosa— increased incidence in atrophic glossitis and burning mouth syndrome (BMS)[J]. J Oral Pathol Med, 2001,30(9):560-563.
[36] Farah CS, Amos K, Leeson R , et al. Candida species in patients with oral dysesthesia: a comparison of carriage among oral disease states[J]. J Oral Pathol Med, 2018,47(3):281-285.
[37] 赵曼, 陈谦明, 林梅 , 等. 灼口综合征患者口腔念珠菌生物类型初探[J]. 实用口腔医学杂志, 2002,18(1):10-12.
Zhao M, Chen QM, Lin M , et al. Identification of oral Candida spieces in patients with burning mouth syndrome[J]. J Pract Stomatol, 2002,18(1):10-12.
[38] Coculescu EC, Tovaru S, Coculescu BI . Epidemiological and etiological aspects of burning mouth syndrome[J]. J Med Life, 2014,7(3):305-309.
[39] Ji EH, Diep C, Liu T , et al. Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics[J]. Mol Pain, 2017,13:1744806916686796.
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