国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (1): 95-101.doi: 10.7518/gjkq.2020009

• 综述 • 上一篇    下一篇

骨微环境相关细胞对肿瘤细胞骨转移的作用及机制

曾刊,李鑫,汪成林,杨静,叶玲()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2019-05-21 修回日期:2019-09-21 出版日期:2020-01-01 发布日期:2020-01-01
  • 通讯作者: 叶玲 E-mail:yeling@scu.edu.cn
  • 作者简介:曾刊,硕士,Email: 1322499644@qq.com
  • 基金资助:
    国家自然科学基金(81771065)

Effects of bone microenvironment cells on tumor bone metastasis

Zeng Kan,Li Xin,Wang Chenglin,Yang Jing,Ye Ling()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-21 Revised:2019-09-21 Online:2020-01-01 Published:2020-01-01
  • Contact: Ling Ye E-mail:yeling@scu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81771065)

摘要:

肿瘤骨转移是肿瘤转移的重要组成部分。肿瘤骨转移的过程往往会经历肿瘤细胞的定植、休眠及活化等。从肿瘤细胞定植到骨微环境中,再到其休眠激活往往经历一段较长的潜伏期。肿瘤骨转移过程中,骨微环境中的成骨细胞、破骨细胞、骨髓基质细胞、免疫细胞及血管内皮细胞对肿瘤细胞的定植、休眠及活化过程有重要影响。在这个过程中,肿瘤细胞除自身调节外,还通过与骨微环境中的各种细胞发生相互作用。本文针对骨微环境中的相关细胞对肿瘤细胞骨转移的作用及机制研究的现状及进展作一综述。

关键词: 肿瘤骨转移, 骨微环境, 休眠, 定植, 扩增

Abstract:

Bone metastasis is an important part of tumor metastasis and includes colonization, dormancy, and proliferation. However, tumor cells undergo a long period of dormancy after colonization. Several cells, including osteoblast, osteoclast, marrow stromal cell, immune cell, and vascular endothelial cell, live in the bone microenvironment and contribute to the progress of bone metastasis. In addition to self-regulation, tumor cells interact with various cells in the bone microenvironment during metastasis. This study aims to analyze the effect of bone microenvironment cells on tumor bone metastasis and further explore such process.

Key words: bone metastasis, bone microenvironment, dormancy, colonization, proliferation

中图分类号: 

  • Q279
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