国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (2): 204-208.doi: 10.7518/gjkq.2018.02.014

• 综述 • 上一篇    下一篇

基质小泡及其与细胞骨架蛋白的关系

冼雪红, 蒋宏伟   

  1. 中山大学光华口腔医学院•附属口腔医院牙体牙髓病科
    广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2017-04-28 修回日期:2017-11-20 出版日期:2018-03-01 发布日期:2018-03-01
  • 通讯作者: 蒋宏伟,副教授,博士,Email:jianghw@163.com
  • 作者简介:冼雪红,硕士,Email:xianxuehong@163.com
  • 基金资助:
    广东省自然科学基金(2014A030313166,2017A030313713)

Matrix vesicles and their relationship with cytoskeleton-associated proteins

Xian Xuehong, Jiang Hongwei   

  1. Guang- hua School of Stomatology, Dept. of Conservative Dentistry and Endodontics, Hospital of Stomatology, Sun Yat-sen University
    Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2017-04-28 Revised:2017-11-20 Online:2018-03-01 Published:2018-03-01
  • Supported by:
    This study was supported by Natural Science Foundation of Guangdong Province (2014A030313166, 2017A030313713).

摘要: 基质小泡作为与矿化密切相关的囊泡,在分泌和矿化过程中实现的多种功能与自身富含的相关蛋白质密不可分。本文就基质小泡及其提取和纯化、蛋白质组学,以及参与其分泌的细胞骨架蛋白等的研究进展进行综述,以便深入认识其相关蛋白质的作用机制,为临床促进矿化研究提供理论依据。

关键词: 基质小泡, 蛋白质组学, 矿化相关蛋白质, 骨架相关蛋白质

Abstract: Matrix vesicles are small vesicles closely associated with mineralisation. During the formation and mineralisation of matrix vesicles, most functions are closely related to their own proteins. This article aims to review the research progress on matrix vesicles, their extraction and purification and proteomic and cytoskeleton-associated proteins related to secretion. Understanding the functions of related proteins and the underlying mechanisms contributes in providing theoretical basis for clinical research on mineralisation.

Key words: matrix vesicles, proteomic analysis, mineralization-related protein, cytoskeleton-associated protein

中图分类号: 

  • Q24
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