灼口综合征的研究进展

doi:10.7518/gjkq.2018.02.006

摘要/Abstract

摘要： 灼口综合征（BMS）是以舌部为主要发病部位、以烧灼样疼痛为主要表现的一组综合征,常不伴有明显的临床损害体征,多发生于更年期前后妇女。如今BMS缺乏统一的诊断标准、明确的病因、确切有效的治疗方法。本文从BMS流行病学现状、诊断标准、分型、病因、治疗方面作一综述。

关键词: 灼口综合征, 流行病学现状, 诊断标准, 分型

Abstract: Burning mouth syndrome (BMS) is a group of syndromes mainly located in the tongue. This syndrome is characterized with burning pain without any visible clinical sign. BMS often develops in perimenopausal women. No uniform diagnostic criteria, clear etiology, or effective treatment method for BMS is available to date. This review introduces the epidemiology, diagnostic criteria, classification, etiology, and treatment of BMS.

Key words: burning mouth syndrome, epidemiology, diagnostic, criteria

中图分类号:

R781.5+9

尹茜, 孙正. 灼口综合征的研究进展[J]. 国际口腔医学杂志, 2018, 45(2): 150-154.

Yin Xi, Sun Zheng. Research progress on burning mouth syndrome[J]. Inter J Stomatol, 2018, 45(2): 150-154.

参考文献

[1] 陈谦明. 口腔黏膜病学[M]. 4版. 北京: 人民卫生出版社, 2012:165-167.
Chen QM.Oral medicine[M]. 4th ed. Beijing: People’s Medical Publishing House, 2012:165-167.
[2] Savage NW, Boras VV, Barker K.Burning mouth syn-drome: clinical presentation, diagnosis and treatment[J]. Australas J Dermatol, 2006, 47(2):77-83.
[3] Barker KE, Savage NW.Burning mouth syndrome: an update on recent findings[J]. Aust Dent J, 2005, 50(4):220-223, 288.
[4] 木冬冬, 苏莎, 金建秋, 等. 灼口综合征口干症状与焦虑抑郁症状的病例对照研究[J]. 中国心理卫生杂志, 2016, 30(4):253-257.
Mu DD, Su S, Jin JQ, et al.A case-control study of relation of xerostomia to anxiety and depression sym-ptoms in patients with burning mouth syndrome[J]. Chin Mental Health J, 2016, 30(4):253-257.
[5] Nasri-Heir C, Zagury JG, Thomas D, et al.Burning mouth syndrome: current concepts[J]. J Indian Pros-thodont Soc, 2015, 15(4):300-307.
[6] Galli F, Lodi G, Sardella A, et al.Role of psychologi- cal factors in burning mouth syndrome: a systematic review and meta-analysis[J]. Cephalalgia, 2017, 37(3):265-277.
[7] Minguez-Sanz MP, Salort-Llorca C, Silvestre-Donat FJ.Etiology of burning mouth syndrome: a review and update[J]. Med Oral Patol Oral Cir Bucal, 2011, 16(2):e144-e148.
[8] Ji EH, Diep C, Liu T, et al.Potential protein bio-markers for burning mouth syndrome discovered by quantitative proteomics[J]. Mol Pain, 2017, 13: 1744806916686796.
[9] Scala A, Checchi L, Montevecchi M, et al.Update on burning mouth syndrome: overview and patient management[J]. Crit Rev Oral Biol Med, 2003, 14(4):275-291.
[10] 刘蓓丽, 叶周熹, 唐国瑶. 原发型灼口综合征疼痛发生的神经机制研究进展[J]. 临床口腔医学杂志, 2012, 28(8):508-510.
Liu BL, Ye ZX, Tang GY.The progress of neural mechanism of primary burning mouth syndrome[J]. J Clin Stomatol, 2012, 28(8):508-510.
[11] Gurvits GE, Tan A.Burning mouth syndrome[J]. World J Gastroenterol, 2013, 19(5):665-672.
[12] Terai H, Shimahara M.Glossodynia from Candida-associated lesions, burning mouth syndrome, or mixed causes[J]. Pain Med, 2010, 11(6):856-860.
[13] Spanemberg JC, Cherubini K, de Figueiredo MA, et al. Aetiology and therapeutics of burning mouth syn-drome: an update[J]. Gerodontology, 2012, 29(2):84-89.
[14] 袁福来. 灼口综合征患者心理健康状况及脑功能影像学研究[D]. 长沙: 中南大学, 2012:12-15.
Yuan FL.The investigation on mental status and func-tional imageology in patients with burning mouth syn-drome[D]. Changsha: Central South University, 2012:12-15.
[15] 王虹. 更年期女性260例的抑郁情绪及更年期症状[J]. 中国老年学杂志, 2010, 30(7):971-972.
Wang H.260 cases of depression and menopausal symptoms among menopausal women[J]. Chin J Gerontol, 2010, 30(7):971-972.
[16] 张齐梅, 聂敏海, 何毅, 等. P2X3受体在灼口综合征患者舌组织神经纤维中的表达[J]. 实用口腔医学杂志, 2016, 32(2):277-279.
Zhang QM, Nie MH, He Y, et al.P2X3 receptor expression in lingual nerve fibres of patients with burning mouth syndrome[J]. J Pract Stomatol, 2016, 32(2):277-279.
[17] Rodríguez-de Rivera-Campillo E, López-López J. Evaluation of the response to treatment and clinical evolution in patients with burning mouth syndrome[J]. Med Oral Patol Oral Cir Bucal, 2013, 18(3):e403-e410.
[18] 苏莎, 刘宏伟, 黄悦勤, 等. 灼口综合征与焦虑抑郁症状的病例对照研究[J]. 中国心理卫生杂志, 2015, 29(10):750-754.
Su S, Liu HW, Huang YQ, et al.A case-control study of burning mouth syndrome and symptoms of anxiety and depression[J]. Chin Mental Health J, 2015, 29(10):750-754.
[19] 李维善, 王爽, 马英君. 女性灼口综合征患者恐癌心理因素分析[J]. 黑龙江医药科学, 2015, 38(4):59-60.
Li WS, Wang S, Ma YJ.Psychological factor analy-sis of female burning mouth syndrome patients fea-ring cancer[J]. Heilongjiang Med Pharm, 2015, 38(4):59-60.
[20] Bilello JA, Thurmond LM, Smith KM, et al.MDD-Score: confirmation of a blood test to aid in the diag-nosis of major depressive disorder[J]. J Clin Psychiatry, 2015, 76(2):e199-e206.
[21] 冯玙, 武志芳. 抑郁患者治疗前后疗效评价方法的研究进展[J]. 中国当代医药, 2015, 22(13):27-31.
Feng Y, Wu ZF.Research advance on evaluation method of curative effect in patient with depression before and after treatment[J]. Chin Modern Med, 2015, 22(13):27-31.
[22] 陈昱, 王宇峰. 灼口综合征神经与精神发病因素的研究进展[J]. 临床口腔医学杂志, 2016, 32(3):189-191.
Chen Y, Wang YF.Research progress on neurolo-gical and psychiatric factors of burning mouth synd-rome[J]. J Clin Stomatol, 2016, 32(3):189-191.
[23] 张丹丹, 孙晓平. 灼口综合征的病因及治疗[J]. 北京口腔医学, 2003, 11(1):55-58.
Zhang DD, Sun XP.The etiology and treatment of burning mouth syndrome[J]. Beijing J Stomatol, 2003, 11(1):55-58.
[24] 杨映阳, 吕宗凯, 杜胜男. 灼口综合征300例临床分析[J]. 医学综述, 2014, 20(14):2687-2688.
Yang YY, Lü ZK, Du SN.Clinical analysis of 300 cases of burning mouth syndrome[J]. Med Recap, 2014, 20(14):2687-2688.
[25] Liu YF, Kim Y, Yoo T, et al.Burning mouth syndro-me: a systematic review of treatments[J]. Oral Dis, 2017. [Epub ahead of print]
[26] Cembrero-Saralegui H, Imbernón-Moya A.RF-burning mouth syndrome: new treatments[J]. Actas Dermosifiliogr, 2017, 108(1):63-64.
[27] 王泽剑, 梁翠玲, 王志铭. 圣约翰草提取物的临床研究进展[J]. 国外医学脑血管疾病分册, 2003, 11(3):212-214.
Wang ZJ, Liang CL, Wang ZM.Progress in the cli-nical study of St. John’s wort extract[J]. Foreign Med Sci: Cerebrovasc Dis, 2003, 11(3):212-214.
[28] Ito M, Tokura T, Yoshida K, et al.Five patients with burning mouth syndrome in whom an antidepressant (serotonin-noradrenaline reuptake inhibitor) was not effective, but pregabalin markedly relieved pain[J]. Clin Neuropharmacol, 2015, 38(4):158-161.
[29] Kim YD, Lee JH, Shim JH.Duloxetine in the treat-ment of burning mouth syndrome refractory to con-ventional treatment: a case report[J]. J Int Med Res, 2014, 42(3):879-883.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed