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01 July 2017, Volume 44 Issue 4 Previous Issue    Next Issue

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Standard procedure and main technique of Abbe flap preparation, transfer and retention Li Yang, Shi Bing Inter J Stomatol. 2017, 44 (4):  373-376.  DOI: 10.7518/gjkq.2017.04.001 Abstract ( 1202 )   HTML ( 13 )   PDF（pc） (1278KB) ( 950 )   Save In order to facilitate the utilization and success rate of Abbe flap, the author initiated a pedicle design procedure with a “window method” at lower lip mucosa on the contralateral side of the pedicle, which aimed at precisely locating the anatomical position of inferior labial artery as well as preserving the mucosa on pedicle side. In this way, the flexibility of Abbe flap could be improved, meanwhile, the survival rate could be secured. Thus, both the safety of Abbe flap technique and the match of upper and lower vermilion could be achieved. References | Related Articles | Metrics

Cleft Lip and Palate

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Psychological nurse care in the treatment of cleft lip and palate Gong Caixia, Ha Pin, Shi Bing Inter J Stomatol. 2017, 44 (4):  377-379.  DOI: 10.7518/gjkq.2017.04.002 Abstract ( 780 )   HTML ( 1 )   PDF（pc） (932KB) ( 563 )   Save In this study, a semi-structured interview was conducted to 172 parents of patients with cleft lip and palate(CLP) in a hospital to obtain information on parents’ needs for psychological care. Results showed that parents paid considerable attention to the psychological health of patients. Furthermore, psychological nurse care was found to be necessary in the treatment of CLP, and it could improve patients and their parents’ satisfaction of the treatment outcomes. Psychological nurse care can also improve the outcomes of the treatment approach for CLP. References | Related Articles | Metrics

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Orthodontic treatment of patients with cleft lip and palate in mixed dentition Pan Yingdan, Liu Yiqin, Xiao Liwei Inter J Stomatol. 2017, 44 (4):  380-384.  DOI: 10.7518/gjkq.2017.04.003 Abstract ( 735 )   HTML ( 4 )   PDF（pc） (970KB) ( 1703 )   Save The mixed dentition stage is a vital period for the orthodontic treatment of patients with cleft lip and palate(CLP). This period marks the time when alveolar bone grafting and growth modification should be implemented. Considering the diversity of malformation, severe craniofacial growth deformity, and particularity of mixed dentition, challenges and controversies of orthodontic treatment arise. We reviewed the procedure and methods of the orthodontic treatment of CLP patients during the mixed dentition stage to provide guidance for clinical application. References | Related Articles | Metrics

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Changes of blood biochemical indexes in 0-6 years old children with cleft lip and palate Pu Hongling, Chen Lixian, Gong Caixia, Wu Min, Shi Bing Inter J Stomatol. 2017, 44 (4):  385-389.  DOI: 10.7518/gjkq.2017.04.004 Abstract ( 992 )   HTML ( 2 )   PDF（pc） (1422KB) ( 221 )   Save Objective To find the relative security range of blood biochemical indexes of children with cleft lip and palate to tolerant the operations in order that more timely treatments would be taken and the sequential therapies would get their best results. Methods The preoperative blood biochemical indexes of 985 completed cases of children with cleft lip and palate were analyzed retrospectively in this study, cross correlation using a variety of statistical analysis methods. Results The inner 95% of the reference values of total bilirubin, direct bilirubin, indirect bilirubin, albumin, creatinine, lymphocytes and red blood cells were all contained in their standard reference value ranges. However, the inner 95% of the reference values of white blood cells, platelets, plasma-albumin/globulin(A/G), alanine aminotransferase(ALT), and aspartate transaminase(AST) were higher than their standard reference value ranges, and the inner 95% of the reference values of hemoglobin, total protein, globulin and serum urea were lower than their standard reference value ranges. The values of hemoglobin, total protein, albumin, globulin and serum urea significantly differed between different sex-groups, and these values in female group were significantly higher than those in male group. The values of red blood cell, hemoglobin, total protein, globulin, serum urea and creatinine of children with simple cleft lip were all higher than those of children with simple cleft palate or cleft lip and palate, while the values of lymphocyte, total bilirubin, direct bilirubin, indirect bilirubin, ALT and AST of children with cleft lip and palate were higher than those of children with simple cleft lip or simple cleft palate. Conclusion The values of white blood cells, platelets, lymphocytes, A/G, ALT, and AST of children with cleft lip and palate may be higher than those of adults. During the preoperative assessment, this study can provide references of the relatively safe biochemical indicators for c operations to catch the best time for operation. In the meantime, the risks in the operations should be noticed as well. References | Related Articles | Metrics

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Research progress on craniofacial growth and development of patients with submucous cleft palate Cao Congcong, Li Jingtao, Zheng Qian Inter J Stomatol. 2017, 44 (4):  390-392.  DOI: 10.7518/gjkq.2017.04.005 Abstract ( 691 )   HTML ( 5 )   PDF（pc） (865KB) ( 510 )   Save The submucous cleft palate is a particular subgroup of cleft palate, a congenital condition associated with abnormal development of the soft palate and various extent of bony defect of the hard palate. Approximately 10% of these patients may have velopharyngeal insufficiency, most of them have been undiagnosed, so the study about submucous cleft palate is rare. This paper reviews the research progress in craniofacial potential of growth and development, the effect of surgery on craniofacial characteristics, and the relation with velopharyngel function of patients with submucous cleft palate. References | Related Articles | Metrics

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Dental anomalies of anterior permanent teeth in patients with cleft lip and palate Chen Zhiyi, Chen Zhenqi Inter J Stomatol. 2017, 44 (4):  393-397.  DOI: 10.7518/gjkq.2017.04.006 Abstract ( 642 )   HTML ( 2 )   PDF（pc） (978KB) ( 424 )   Save The cleft lip and palate(CLP) is the most common oral and maxillofacial congenital anomaly. Dental anomalies, especially in the maxilla anterior region, are associated with presence of CLP. Since the studies concerning various dental anomalies in patients with CLP lack in China, in this literature review the authors concentrate on the abnormality of the shape, number, size, eruption and root development of anterior permanent teeth in patients with various types of CLP, in order to provide the evidence or reference for dentists to make the treatment plan and to reduce the complexity and difficulty of the treatment.. References | Related Articles | Metrics

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Preliminary analysis on correlations between the symptoms related to upper respiratory infection and vital signs after operation of infants with cleft lip and/or palate Song Lei, Jiang Shuyuan, Jia Zhonglin, Shi Bing, Gong Caixia, Li Yang Inter J Stomatol. 2017, 44 (4):  398-404.  DOI: 10.7518/gjkq.2017.04.007 Abstract ( 781 )   HTML ( 2 )   PDF（pc） (1074KB) ( 253 )   Save Objective This study aims to test the correlations between upper respiratory infection(URI) and vital signs after cleft lip and/or palate(CL/P) surgery to find out some preoperative manifestations that may predict surgical risk. Methods The investigators implemented retrospective studies. A total of 1 000 medical records of infants who had CL/P surgery were randomly collected. The predictor variable was several preoperative symptoms related to URI, and the outcome variable was vital signs after operation. Then, two kinds of variables were exchanged. Descriptive and univariate analyses were computed to find the links. Results About 93.3% of the infants suffered abnormal vital signs within 24 h after operation, but most complications were mild. Two groups, which were divided by whether the highest preoperative temperature was normal or not, had statistically different proportions of abnormal postoperative temperature and systolic blood pressure(SBP) (P<0.05). Univariate analysis results: an excessive white blood cell count caused statistically different postoperative SBP and respiratory rate, as compared with the normal white blood cell count(P<0.05). A fever caused different postoperative temperature, SBP, and respiratory rate(P<0.05). A diagnosis of URI caused different postoperative SBP and oxyhemoglobin saturation(P<0.05). Conclusion Tolerating CL/P surgery under general anesthesia is relatively safe for children with only slight URI symptoms, whereas a careful monitoring is indispensable. Moreover, temperature before surgery is a sensitive indicator, and white blood cell count and diagnosis of URI are also ponderable. References | Related Articles | Metrics

Original Articles

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Stabilization splint treatment for chronic temporomandibular joint disk displacement without reduction: a systematic review based on randomized controlled trials Li Jing, Liu Xingchen, Li Jiayuan, Li Xiaobing Inter J Stomatol. 2017, 44 (4):  405-410.  DOI: 10.7518/gjkq.2017.04.008 Abstract ( 828 )   HTML ( 8 )   PDF（pc） (1227KB) ( 298 )   Save Objective This study aims to assess the efficacy of stabilization splint(SS) treatment on patients with chronic temporomandibular joint disk displacement without reduction(DDwoR) through systematic review of relevant randomized controlled trials. Methods An electronic search strategy was performed on Cochrane Central, Medline, EMBASE(Ovid), Chinese Biomedical Database, and China National Knowledge Infrastructure until July 2015. A manual search covering 19 dental journals in Chinese was performed as well. Data extraction of included studies and risk of bias assessment with the recommended tool of Cochrane Collaboration was then performed. Meta-analysis was processed by Rveman 5.3.5. Results Four studies of unclear risk of bias and two studies of high-risk bias were included. Compared with other conservative therapies, SS did not show a significant advantage(P>0.05) on pain relief and maximal mouth opening of DDwoR patients in the short term. However, SS may have increased the success rate(P<0.01) in the long term. Conclusion High-quality randomized controlled trials are necessary for the evaluation of the long-term efficacy of SS treatment on chronic DDwoR. References | Related Articles | Metrics

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Biofilm formation and antimicrobial susceptibility of Streptococcus mitis in response to luxS/AI-2 signaling Lu Xiao, Weng Chunhui, Wang Jinming, Liu Shaojuan, Liu Qin, Lin Shan Inter J Stomatol. 2017, 44 (4):  411-420.  DOI: 10.7518/gjkq.2017.04.009 Abstract ( 799 )   HTML ( 3 )   PDF（pc） (1467KB) ( 447 )   Save Objective This paper aims to study the influence of luxS gene mutation of Streptococcus mitis on biofilm formation and antimicrobial susceptibility. Methods Culture in blood plate, Gram stain and susceptibility tests, and phy-siological and biochemical tests were first carried out. 16S ribosomal DNA(rDNA) sequence homology analysis of clinical isolate was examined subsequently. The autoinducer-2(AI-2) bioluminescence assay of Vibrio harveyi BB170 strain, multi-drug resistance, and ability of biofilm formation were examined in luxSmutant and clinical isolate. The structure, exopo-lysaccharides, and dead/live cells of biofilm were scanned by confocal laser scanning microscope. Compared with one another, luxS mutant growth recruited by isolate supernatant or 4,5-dihydroxy-2,3-pentanedione(DPD) was experimented. Results luxS gene deletion decreased biofilm formation(P<0.001), loosened structure, and changed antimicrobial suscepti-bility(to ampicillin, ciprofloxacin, tetracycline). However, isolate supernatant or DPD can recover the structure and ability of biofilm formation in luxS mutant. Conclusion luxS/AI- 2 signaling can influence biofilm formation and antimicro-bial susceptibility of S. mitis with multidrug resistance. References | Related Articles | Metrics

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Effect of nicotine and mecamylamine on growth of periodontal pathogens Liu Shiyu, Tian Mi, Shi Liran, Pan Weilin, Wang Yiyao, Li Mingyun Inter J Stomatol. 2017, 44 (4):  421-425.  DOI: 10.7518/gjkq.2017.04.010 Abstract ( 957 )   HTML ( 7 )   PDF（pc） (1196KB) ( 601 )   Save Objective This work aims to study the effects of nicotine and mecamylamine on periodontal pathogen growth and pathogen-formed biofilms. Methods Doubling dilution was used to determine the minimum inhibition concentration(MIC) and minimum bactericidal concentration(MBC) of nicotine on Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. The influences of 1/16 MIC, 1/8 MIC, 1/4 MIC, 1/2 MIC, and MIC of nicotine on the biofilms formed by P. gingivalis and A. actinomycetemcomitans were studied by light absorbance determination on a microplate reader. Results The MIC of nicotine against planktonic P. gingivalis was 8 mg·mL-1, which was similar to that of A. actinomycetemcomitans. When the nicotine concentration increased by a degree, the absorbance of the two bacterial biofilms increased. However, the absorbance decreased at further increase in nicotine concentration. The absorbance decreased to a minimum at a nicotine concentration of 8 mg·mL-1, which was also the minimum biofilm inhibition concentration. The group with mecamylamine(nicotine-receptor antagonist) showed higher absorbance than the control group. Conclusion Minimal doses of nicotine can promote the biofilm formation of P. gingivalis and A. actinomycetemcomitans, and continued increase in nicotine concentration inhibits biofilm formation. In the presence of mecamylamine, nicotine increases the biofilms formed by the P. gingivalis and A. actinomycetemcomitans. This effect is attributed to the decrease in nicotine concentration caused by mecamylamine. References | Related Articles | Metrics

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Clinical effect observation of improved aesthetic clasp in distal-extension prosthesis Men Qinglin, Zhou Xianhua, Wang Wei Inter J Stomatol. 2017, 44 (4):  426-429.  DOI: 10.7518/gjkq.2017.04.011 Abstract ( 949 )   HTML ( 10 )   PDF（pc） (961KB) ( 361 )   Save Objective To compare the clinical effect of RPI and improved esthetic clasps in distal-extension prosthesis. Methods A total of 84 cases of patients with distal-extension prosthesis are to be chosen and randomly divided into two groups: RPI clasp repair group and modified esthetic clasp repair group. The repair effects of the two methods are to be compared via questionnaires after 1, 3, and 6 months. Results No statistically significant differencewas observed in terms of the masticatory function, retention, stabilization, and food impaction. However, in terms of appearance and comfort, the improved esthetic clasp group is evidently better than the RPI group(P<0.05). Conclusion Compared with the traditional RPI removable partial denture, the improved esthetic clasp denture can provide better esthetic repair effects and comfort for patients with distal-extension prosthesis, which will ensure that the needs of the patients are well attended to. References | Related Articles | Metrics

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Influence of different adhesive materials on the shear bond strength of metal brackets to porcelain surface Ding Hong, Chen Jifen, Wu Jianyong Inter J Stomatol. 2017, 44 (4):  430-432.  DOI: 10.7518/gjkq.2017.04.012 Abstract ( 778 )   HTML ( 4 )   PDF（pc） (1013KB) ( 330 )   Save Objective This study aims to investigate the influence of different adhesive materials on the shear bond strength of metal brackets bonded to porcelain surfaces. Methods A total of 40 porcelain specimens were deglazed, etched, rinsed, dried, and treated with silane coupling agent. Then, the 40 porcelain specimens were divided into 4 groups. A total of 40 metal brackets were bonded to each group with the following 4 adhesive materials: light-cured composite resin(group A), one-component chemically cured composite resin(group B), resin-modified light-cured glass ionomer cements(group C), and two-component chemically cured resin adhesive(group D). All specimens were placed with surrounding air and then stored in an artificial saliva bath for 24 h. Shear bond strength was measured by an Instron universal testing machine. Statistical analyses were performed by ANOVA. Results The shear bond strength of group A was the highest among those of the others(P<0.05). Meanwhile, the shear bond strength of group C was lower than that of group B(P<0.05). No statistically significant difference was found between groups B and D and between groups C and D(P>0.05). Conclusion Light-cured composite resin can acquire the highest shear bond strength among those of the porcelain materials tested. Resin-modified light-cured glass ionomer cements were found unsuitable for use as adhesive to bond metal brackets onto porcelain surfaces. References | Related Articles | Metrics

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A clinical study on the choice of etching agent for pit and fissure sealing in younger children Gao Xuebin, Zhang Qi, Li Jing, Bi Ye, Yang Hua, Huang Yang Inter J Stomatol. 2017, 44 (4):  433-436.  DOI: 10.7518/gjkq.2017.04.013 Abstract ( 1097 )   HTML ( 8 )   PDF（pc） (907KB) ( 402 )   Save Objective Compare the retention rate of fissure sealants when using self-etching adhesive and phosphate acid for the clean tooth surfaces of young children. To evaluate the effect of the application of pit and fissure sealant with self-etching adhesives and phosphoric acid. Methods Sixty-seven children with complete eruption and no caries of the four second primary molars were selected as the study subjects. Totally 268 teeth of the second primary molars were used as test teeth, divided into four groups with the method of self control test. The right Group A(maxillary) and B(mandibular) were treated with self-etching adhesive, and the left Group C(maxillary) and D(mandibular) with phosphate-acid etching method. All the children were followed up and the rate of shedding of the four groups was compared after 3, 6, 12 and 24 months. Results The retention rates of pit and fissure sealant in four groups(A~D) had no significant difference after 3 and 6 months(P>0.05). At the 12 months, there was significant difference between the A, C group and the D group(P<0.05), but there was no significant difference between the B, D group and the A, B, C group respectively(P>0.05). At the 24 months, the retention rate of pit and fissure sealant in Group D was statistically lower than in the A, B, C group(P<0.05), but the other three groups(A, B, C) had no significant difference in the retention rate of pit and fissure sealant(P>0.05). The retention rate of the mandibular group with phosphoric acid etching was significantly lower than the other three groups. Conclusion The mandibular molars are more susceptible to saliva contamination. Self-etching adhesive can reduce the influence of saliva pollution and improve retention rate of fissure sealing. It is recommended to be used for young children in clinical. References | Related Articles | Metrics

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Outcomes of 24 cases of autologous tooth transplantation Hu Jun, Li Xiufen, Hua Chengge, Ma Liyuan Inter J Stomatol. 2017, 44 (4):  437-439.  DOI: 10.7518/gjkq.2017.04.014 Abstract ( 818 )   HTML ( 9 )   PDF（pc） (894KB) ( 600 )   Save Objective To observe the clinical outcomes of autologous tooth transplantation(ATT). Methods Twenty-four patients whose first or second molar needed to be extracted and third molar could be extracted completely were subjected for ATT. The survival rate of transplanted third molar was observed, and the outcomes were analyzed considering age, gender and location. Results The survival rate of transplanted third molar was 87.5%(21/24). There was no differences between whatever age, gender and location. Conclusion ATT is proved to be an alternative treatment for dentition defect. Recently, the using of results from clinical researches in tooth transplantation and replantation do actively improve the clinical outcome of ATT. Aged people should not be excluded from ATT, because the age is not a definite negative fact of prognosis. References | Related Articles | Metrics

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Clinical evaluation of interproximal caries restoration with orthodontic elastic separators Liang Jichao, Wang Fen, Zhang Zhenghua, Pang Fusheng, Hou Meijuan, Zhang Fengying Inter J Stomatol. 2017, 44 (4):  440-444.  DOI: 10.7518/gjkq.2017.04.015 Abstract ( 1019 )   HTML ( 6 )   PDF（pc） (997KB) ( 253 )   Save Objective To evaluate the clinical effect of orthodontic elastic separators on early interproximal caries restorated by composite resin. Methods Total 120 teeth with interproximal caries from 76 patients were included and were randomly divided into orthodontic separator techniques group or routine repair group. The teeth in routine repair group were prepared and filled by traditional approach, and those in orthodontic group were prepared and filled by traditional approach but following used separators to divide teeth for 3 days. The types of cavity were compared after treatment. The clinical evaluation was performed according to modified United States Public Health Service criteria at one week and one year after treatment. Results Fifty-eight cavities including 50 simple cavity and 8 double-faced cavity were filled in orthodontic group, and 62 teeth including 14 single cavity and 48 double-faced cavity were filled in routine group, the ratio of simple cavity in orthodontic group are significantly higher than that in routine group(P<0.05). After one year, there are no significant difference of integrity of the restorations in orthodontic and routine groups, which success rate were 100% and 96.61% respectively(P>0.05), and the success rate without secondary caries in orthodontic group was 94.64%, higher than that of routine group(84.75%), without statistical difference(P>0.05). But the success rate of marginal discoloration, food impaction and gingivitis evaluation indicators in orthodontic group were higher than routine group(P<0.05). Conclusion Using orthodontic elastic separators was conducive to accurate preparation, retained more tooth tissues, and available fine polishing, which could improve the clinical curative effect. References | Related Articles | Metrics

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Validation of a Chinese version of oral health-related quality of life in children Lin Jiu, Yu Fanyuan, Fang Xinyi, Ha Pin, Gong Caixia, Shi Bing Inter J Stomatol. 2017, 44 (4):  445-451.  DOI: 10.7518/gjkq.2017.04.016 Abstract ( 916 )   HTML ( 8 )   PDF（pc） (1021KB) ( 605 )   Save Objective To translate the original English version of child oral health impact profile(COHIP) into Chinese version and test its psychometric properties for use among Chinese eligible children. Methods The original English version of COHIP was translated, back-translated and cross-cultural adapted. Content validity index(CVI) scale and self-assessment for oral health and need for treatment questionnaire were established. Its reliability and validity were assessed in Chinese children aged 8 to15 years and their parents. Results Scales were completed by 1 189 pairs of children and parents, and 1 143 efficient scales were taken back, with the completion 96.1%. Cronbach’s α of COHIP(for child) was 0.903, item-total correlation coefficient ranged from 0.134 to 0.611, split-half reliability coefficient was 0.798, interclass correlation coefficient(ICC) was 0.926. Cronbach’s α of COHIP(for caregiver) was 0.796, item-total correlation coefficient ranged from 0.121 to 0.614, split-half reliability coefficient was 0.796, ICC was 0.931. Factor analysis found that there was certain logical relation among the items in Chinese version of COHIP. Conclusion The translated Chinese version of COHIP demonstrates acceptable reliability and validity. Its satisfying psychometric properties provide the theoretical evidence for further use in Chinese children. References | Related Articles | Metrics

Reviews

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Research progress on association between single nucleotide polymorphism and chronic periodontitis Yang Chunyan, Shui Yanqing Inter J Stomatol. 2017, 44 (4):  452-458.  DOI: 10.7518/gjkq.2017.04.017 Abstract ( 783 )   HTML ( 3 )   PDF（pc） (1067KB) ( 191 )   Save Single nucleotide polymorphism(SNP) is a genetic marker and refers to a variation in a single nucleotide that occurs at a specific location in the genome, chronic periodontitis is a chronic infectious disease of the dental supportive tissue influenced by multiple factors, there is close correlation between them, the study mainly focus on the encoding gene polymorphisms of cytokines, cell membrane receptors, chemokines and enzymes and so forth, which play roles during the immune system recognizing bacteria, eliminating bacteria, tissue destruction progress or metabolic mechanisms. This article reviews the association between the susceptibility to chronic periodontitis and the SNPs of five gene families including interleukin, tumor necrosis factor, Fcγ receptor, Vitamin D receptor and matrix metalloproteinase and to seek for diagnostic basis of chronic periodontitis from a single nucleotide polymorphic perspective. References | Related Articles | Metrics

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Regulation of Wnt and Notch signaling pathways in the osteogenic differentiation of bone marrow-derived mesen-chymal stem cells from aged individuals Zhang Jiankang, Wei Junjun, Tang Zhaolong, Yu Yunbo, Jing Wei Inter J Stomatol. 2017, 44 (4):  459-465.  DOI: 10.7518/gjkq.2017.04.018 Abstract ( 742 )   HTML ( 5 )   PDF（pc） (1067KB) ( 563 )   Save The impaired bone healing process in aged individuals is a common clinical problem. Bone marrow-derived mesenchymal stem cells(BMSCs), a group of pluripotent stem cells located in the bone marrow, are functional cells of new bone formation and bone metabolism. Its biological characteristics(including cell morphology, surface features, cell cycle, and level of reactive oxygen species) and proliferation and differentiation ability are varied with age, which directly affects the bone healing speed and quality at the bone injury site. Signaling pathways play a crucial role in the osteogenic differentiation of BMSCs from aged individuals. Wnt and Notch signaling pathways have been widely reported and have attracted increasing attention from the scholars in recent years. The changes of oxidative stress and growthfactors among aged individuals inhibit β-catenin activity directly by preventing β-catenin and binding its target site T cell factor and lymph enhancement factor instead of the binding fork head transcription factor and repress target gene expressions. Notch signaling pathway represses the differentiation and promotes the proliferation of BMSCs to maintain the number of BMSCs in bone marrow. The cross talk is between Notch and Wnt/β-catenin signaling pathways. Notch1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin. It also plays an important role in the osteogenic differentia-tion of BMSCs from aged individuals. Moreover, the reactive oxygen species(ROS) level down-regulates bone morpho-genetic protein(BMP)-Smads and Hedgehog. Several other pathways also participate in the regulation process. This review summarizes the mechanism that Wnt/β-catenin and Notch signaling pathways regulate the osteogenic differentiation of BMSCs from aged individuals. This review may provide a new approach for the treatment of bone-related diseases in the senior population. References | Related Articles | Metrics

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Research progress on the regulation of parathyroid hormone on the remodeling of periodontal tissues An Ning, Tang Zhenglong Inter J Stomatol. 2017, 44 (4):  466-470.  DOI: 10.7518/gjkq.2017.04.019 Abstract ( 798 )   HTML ( 3 )   PDF（pc） (960KB) ( 562 )   Save Parathyroid hormone(PTH) is a polypeptide molecule synthesized and secreted by the chief cell of parathyroid glands and is a vital calcium-regulating hormone, which could maintain the balance of calcium and phosphorus metabolism in vivo. PTH could promote the regeneration and absorption of bone and accelerate bone turnover. Nowadays, PTH is used for the prevention and treatment of osteoporosis in menstruating women and could decrease the rate of fracture in clinic. Moreover, researchers found that PTH could promote the concrescence and remodeling of periodontal tissue, control the absorption of alveolar bone, accelerate orthodontic tooth movement, and improve the osseointegration of dental implant by stimulating the proliferation and differentiation of osteoblast, osteoclast, periodontal ligament cell, and cementoblast. This review focuses on the progress of PTH in the regeneration and remodeling of periodontal tissue in recent years. References | Related Articles | Metrics

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Review of bioactive resins in inducing dentin remineralization Huang Zihua, Wu Shiyu, Mai Sui Inter J Stomatol. 2017, 44 (4):  471-476.  DOI: 10.7518/gjkq.2017.04.020 Abstract ( 749 )   HTML ( 9 )   PDF（pc） (980KB) ( 408 )   Save Dentin remineralization is one of the most important methods to improve resin-dentin bonding durability. However, the limited mineral ion supply limits the remineralization of demineralized dentine. Experimental adhesives doped with inorganic fillers are proven bioactive and can release mineral ions. These inorganic materials include silicate, calcium phosphate, and bioactive glass. Many studies have proven that these bioactive resins can induct the remineralization of dentine and protect collagen fibrils. Some of the studies also showed the poor mechanical properties of the resins. Synthesizing new bioactive resins with excellent mechanical properties is important. This review presents the effects of the bioactive restorative composite in dentin remineralization. References | Related Articles | Metrics

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Research on Candida albicans in the denture stomatitis Zhou Yujie, Ren Biao, Cheng Lei, Zhou Xuedong Inter J Stomatol. 2017, 44 (4):  477-483.  DOI: 10.7518/gjkq.2017.04.021 Abstract ( 679 )   HTML ( 2 )   PDF（pc） (1152KB) ( 393 )   Save Denture stomatitis is a common disorder affecting denture wearers. The typical symptom of denture stomatitis is characterized as inflammation and erythema of the oral mucosal areas covered by the denture. However, the etiology of denture stomatitis is not completely understood. A large number of surveys have shown a strong link between Candida albicans and denture stomatitis. Basically, the C. albicans pathogenicity included different factors: adhesins, secreted enzymes, and the diversity of morphological. The virulence factors involved in the pathogenic procedures are usually mediated by one or more signal pathways of correlated genes. The aim of this paper is to review current understanding on the roles of C. albicans and its virulence factors during the denture stomatitis development, as well as the reactions of host cells when infected by C. albicans. References | Related Articles | Metrics

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Nucleotide-binding oligomerization domain-like-receptor family pyrin domain 3 inflammasome and periodontitis Wang Nana, Chen Lili, Ding Peihui Inter J Stomatol. 2017, 44 (4):  484-487.  DOI: 10.7518/gjkq.2017.04.022 Abstract ( 772 )   HTML ( 2 )   PDF（pc） (951KB) ( 225 )   Save Studies have shown that periodontitis has a certain relationship with nucleotide-binding oligomerization domain-like receptor family pyrin domain(NLRP)3 inflammasome. NLRP3 inflammasome plays an important role in the immune defense reaction of periodontal disease through regulating the release of interleukin(IL)-1β. NLRP3 inflammasome is comprised of NLRP3, apoptosis-associated speck-like protein, and cysteinyl aspartate-specific protease-1 and could promote the release of cytokines, thus removing pathogens and causing cell-related apoptosis. NLRP3 inflammasome is relevant with many oral diseases, such as chronic pulpitis and chronic apical periodontitis. This review will focus on NLRP3 inflammasome and its relevance with periodontitis. References | Related Articles | Metrics

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Role and mechanism of the calcitonin gene related peptide in bone tissue regeneration Wu Caijuan, Yang Lan, Guo Lühua Inter J Stomatol. 2017, 44 (4):  488-492.  DOI: 10.7518/gjkq.2017.04.023 Abstract ( 1038 )   HTML ( 3 )   PDF（pc） (968KB) ( 247 )   Save Insufficient bone mass is a common problem in oral implant prostheses. The widely used bone regeneration methods in clinical applications include autologous bone grafting and the use of biological bone powder and platelet-rich fiber membrane. Despite the variations in all the methods, the clinical effects are unremarkable. Bones involve a dynamic organization mediated by osteoclast and osteoblast metabolism, which is influenced by various systemic factors. Calcitonin gene related peptides(CGRP) are extensively distributed neuropeptides in the body. Many studies have shown that CGRP plays an important role in bone metabolism, especially in osteogenesis. However, the specific mechanism of CGRP in osteogenesis is unclear and requires further investigation and discussion. Therefore, we conducted this review to study the role and mechanism of CGRP. References | Related Articles | Metrics

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Research progress on the effectiveness assessment of decompression on large jaw cystic lesions Zhang Qian, Yang Xudong Inter J Stomatol. 2017, 44 (4):  493-496.  DOI: 10.7518/gjkq.2017.04.024 Abstract ( 867 )   HTML ( 9 )   PDF（pc） (945KB) ( 326 )   Save Decompression has been applied in the primary treatment of large jaw cystic lesions, as the intracystic pressure is released after opening windows in the surface of lesions. Such process has been extensively applied to ensure safety and effectiveness, as it can promote shrinkage, protect adjacent tissues, and possibly reduce the risk of recurrence in the treat-ment of keratocystic odontogenic tumor and unicystic ameloblastoma. Studies that aimed to assess the effectiveness of decompression on large jaw cystic lesions and to determine the time of secondary curettage surgery have been conducted recently. However, no consensus has been made. The paper presents recent studies on evaluation methods on the effectiveness of decompression on large jaw cystic lesions. The literature on the time of secondary curettage surgery is also reviewed. References | Related Articles | Metrics