%A Zhang Mingshuang,Ba Te,Wang Wenbiao %T Research progress on oral microorganisms affect Alzheimer’s disease %0 Journal Article %D 2020 %J Int J Stomatol %R 10.7518/gjkq.2020012 %P 102-108 %V 47 %N 1 %U {https://www.gjkqyxzz.cn/CN/abstract/article_13606.shtml} %8 2020-01-01 %X

Oral microorganisms such as bacteria and fungi can cause a series of oral diseases, including caries and periodontitis. Some oral pathogens can cause systemic inflammation by secreting metabolites into the blood. Alzheimer’s disease (AD), a neurodegenerative disease, is the most common form of dementia. According to the World Health Organization, AD accounts for 60%-70% of dementia cases. With its morbidity increasing annually, AD has become one of the world’s most difficult problems. Amyloid β-protein (Aβ) deposition, hyperphosphorylation of tau protein, and loss of neurons with glial cell proliferation have been found in the brains of patients with AD. However, the pathogenesis of AD has not been elucidated. Recent studies reported that some oral microorganisms causing chronic periodontitis had become a significant risk factor for Aβ deposition and AD. Therefore, this article reviews the relationship between oral microorganisms and potential pathogenesis of AD.