Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (1): 58-63.doi: 10.7518/gjkq.2021007

• Reviews • Previous Articles     Next Articles

Effect of adiponectin on bone marrow mesenchymal stem cells and its regulatory mechanisms

Chen Ye,Zhou Feng,Wu Qionghui,Che Huiling,Li Jiaxuan,Shen Jiaqi,Luo En()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-04-12 Revised:2020-09-03 Online:2021-01-01 Published:2021-01-20
  • Contact: En Luo E-mail:luoen521125@sina.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81970917).(81970917)

RichHTML

16

PDF (PC)

184

Abstract:

Bone marrow mesenchymal stem cells (BMSCs) are a research hotspot for the treatment of cranio-maxillofacial bone diseases. The function of BMSCs with regard to proliferation, differentiation, migration and survival ability in the tissue environment determines the quality and speed of bone repair and reconstruction. Adiponectin (APN) is an adipokine factor secreted primarily by adipose tissue. Apart from being closely related to lipid metabolism, APN can also affect the process of osteogenesis by regulating the function of BMSCs in a variety of ways, which plays an important role in regulating the balance of bone-lipid metabolism. In the article, the biological characteristics of APN and role of APN in regulating the proliferation, osteogenic differentiation, migration and survival ability of BMSCs and related signalling pathways are reviewed to provide new ideas for the prevention and treatment of bone-related diseases such as osteoporosis.

Key words: adiponectin, bone marrow mesenchymal stem cells, osteogenesis

CLC Number: 

  • R336

TrendMD: 
[1] Marasini S, Chang DY, Jung JH , et al. Effects of adenoviral gene transduction on the stemness of human bone marrow mesenchymal stem cells[J]. Mol Cells, 2017,40(8):598-605.
pmid: 28835020
[2] Lin W, Xu G . Over-expression of CNTF in bone marrow mesenchymal stem cells protects RPE cells from short-wavelength, blue-light injury[J]. In Vitro Cell Dev Biol Anim, 2018,54(5):355-365.
[3] Wang JC, Liu SZ, Shi JY , et al. The role of lncRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells[J]. Curr Stem Cell Res Ther, 2020,15(3):243-249.
pmid: 31880266
[4] 王泽昊, 岳兵, 蒋国强 . 骨髓间充质干细胞的示踪技术研究进展[J]. 中华骨科杂志, 2017,37(18):1171-1176.
Wang ZH, Yue B, Jiang GQ . Advances in tracing techniques of bone marrow mesenchymal stem cells[J]. Chin J Orthop, 2017,37(18):1171-1176.
[5] Yin GZ, Liu HH, Li JY , et al. Adenoviral delivery of adiponectin ameliorates osteogenesis around implants in ovariectomized rats[J]. J Gene Med, 2019,21(2/3):e3069.
[6] Pal China S, Sanyal S, Chattopadhyay N . Adiponectin signaling and its role in bone metabolism[J]. Cytokine, 2018,112:116-131.
[7] Katira A, Katira A, Tan PH , et al. Evolving role of adiponectin in cancer-controversies and update[J]. Cancer Biol Med, 2016,13(1):101-119.
[8] Wang CY, Tian L, Yu XJ . Hormones and their receptors bridge fat and bone metabolisms[J]. Curr Signal Transduct Ther, 2015,10(1):17-30.
[9] Naot D, Musson DS, Cornish J . The activity of adiponectin in bone[J]. Calcif Tissue Int, 2017,100(5):486-499.
pmid: 27928591
[10] Krumbholz G, Junker S, Meier FMP , et al. Response of human rheumatoid arthritis osteoblasts and osteoclasts to adiponectin[J]. Clin Exp Rheumatol, 2017,35(3):406-414.
pmid: 28079506
[11] Yu LM, Tu QS, Han QQ , et al. Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes[J]. Stem Cells, 2015,33(1):240-252.
[12] Pu YF, Wang MK, Hong YY , et al. Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8[J]. J Cell Mol Med, 2017,21(7):1411-1419.
doi: 10.1111/jcmm.13070 pmid: 28176455
[13] Wang F, Wang PX, Wu XL , et al. Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice[J]. PLoS One, 2013,8(7):e68497.
[14] Kajimura D, Lee HW, Riley KJ , et al. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1[J]. Cell Metab, 2013,17(6):901-915.
[15] Luo Y, Zhang YD, Miao GJ , et al. Runx1 regulates osteogenic differentiation of BMSCs by inhibiting a-dipogenesis through Wnt/β-catenin pathway[J]. Arch Oral Biol, 2019,97:176-184.
[16] Berendsen AD, Olsen BR . Regulation of adipogenesis and osteogenesis in mesenchymal stem cells by vascular endothelial growth factor A[J]. J Intern Med, 2015,277(6):674-680.
pmid: 25779338
[17] Kim JH, Liu X, Wang JH , et al. Wnt signaling in bone formation and its therapeutic potential for bone diseases[J]. Ther Adv Musculoskelet Dis, 2013,5(1):13-31.
pmid: 23514963
[18] 张建康, 卫俊俊, 唐曌隆 , 等. Wnt和Notch通路在老龄个体骨髓间充质干细胞成骨中的调控[J]. 国际口腔医学杂志, 2017,44(4):459-465.
Zhang JK, Wei JJ, Tang ZL , et al. Regulation of Wnt and Notch signaling pathways in the osteogenic differentiation of bone marrow-derived mesenchymal stem cells from aged individuals[J]. Int J Stomatol, 2017,44(4):459-465.
[19] Wang YY, Zhang XH, Shao J , et al. Adiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt/β-catenin pathway[J]. Sci Rep, 2017,7(1):3652.
[20] Lin YY, Chen CY, Chuang TY , et al. Adiponectin receptor 1 regulates bone formation and osteoblast differentiation by GSK-3β/β-catenin signaling in mice[J]. Bone, 2014,64:147-154.
doi: 10.1016/j.bone.2014.03.051 pmid: 24713193
[21] Chen EM, Liu GY, Zhou XP , et al. Concentration-dependent, dual roles of IL-10 in the osteogenesis of human BMSCs via P38/MAPK and NF-κB signaling pathways[J]. FASEB J, 2018,32(9):4917-4929.
pmid: 29630408
[22] Pu Y, Wu H, Lu S , et al. Adiponectin promotes human jaw bone marrow stem cell osteogenesis[J]. J Dent Res, 2016,95(7):769-775.
pmid: 26961489
[23] Lee HW, Kim SY, Kim AY , et al. Adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells[J]. Stem Cells, 2009,27(9):2254-2262.
[24] Liu XH, Chen T, Wu YW , et al. Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells[J]. Biochem Biophys Res Commun, 2017,483(1):712-717.
[25] Wu YW, Tu QS, Valverde P , et al. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice[J]. Am J Physiol Endocrinol Metab, 2014,306(12):E1418-E1430.
doi: 10.1152/ajpendo.00048.2014 pmid: 24780611
[26] Yang SM, Liu HH, Liu Y , et al. Effect of adiponectin secreted from adipose-derived stem cells on bone-fat balance and bone defect healing[J]. J Tissue Eng Regen Med, 2019,13(11):2055-2066.
doi: 10.1002/term.v13.11
[27] Fu X, Liu G, Halim A , et al. Mesenchymal stem cell migration and tissue repair[J]. Cells, 2019,8(8):784.
[28] Yu L, Tu Q, Han Q , et al. Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes[J]. Stem Cells, 2015,33(1):240-252.
doi: 10.1002/stem.1844 pmid: 25187480
[29] Wu X, Qiu W, Hu Z , et al. An adiponectin teceptor agonist reduces type 2 diabetic periodontitis[J]. J Dent Res, 2019,98(3):313-321.
pmid: 30626266
[30] Chen X, Hu JG, Huang YZ , et al. Copper promotes the migration of bone marrow mesenchymal stem cells via Rnd3-dependent cytoskeleton remodeling[J]. J Cell Physiol, 2020,235(1):221-231.
[31] Tian XQ, Yang YJ, Li Q , et al. Globular adiponectin inhibits the apoptosis of mesenchymal stem cells induced by hypoxia and serum deprivation via the adipoR1-mediated pathway[J]. Cell Physiol Biochem, 2016,38(3):909-925.
[32] Zhao L, Fan CX, Zhang Y , et al. Adiponectin enhances bone marrow mesenchymal stem cell resistance to flow shear stress through AMP-activated protein kinase signaling[J]. Sci Rep, 2016,6:28752.
doi: 10.1038/srep28752 pmid: 27418435
[33] Malih S, Saidijam M, Mansouri K , et al. Promigratory and proangiogenic effects of AdipoRon on bone marrow-derived mesenchymal stem cells: an in vitro study[J]. Biotechnol Lett, 2017,39(1):39-44.
doi: 10.1007/s10529-016-2214-0 pmid: 27627895
[34] Hu LF, Yin C, Zhao F , et al. Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment[J]. Int J Mol Sci, 2018,19(2):E360.
pmid: 29370110
[35] Greco EA, Lenzi A, Migliaccio S . The obesity of bone[J]. Ther Adv Endocrinol Metab, 2015,6(6):273-286.
doi: 10.1177/2042018815611004 pmid: 26623005
[36] Weinberg E, Maymon T, Weinreb M . AGEs induce caspase-mediated apoptosis of rat BMSCs via TNFα production and oxidative stress[J]. J Mol Endocrinol, 2014,52(1):67-76.
[37] Keats EC, 2ndDominguez JM, Grant MB, et al. Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis[J]. Stem Cells, 2014,32(6):1649-1660.
doi: 10.1002/stem.1659 pmid: 24496952
[38] Zhu LL, Chen XZ, Chong L , et al. Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway[J]. Int Immunopharmacol, 2019,67:396-407.
doi: 10.1016/j.intimp.2018.12.030 pmid: 30584969
[1] Mei Hongxiang,Zhang Yidan,Zhang Chenghao,Liu Enyan,Chen Hao,Zhao Zhihe,Liao Wen. Effect of epigallocatechin-3-gallate on stem cell proliferation and osteogenic differentiation [J]. Int J Stomatol, 2019, 46(4): 431-436.
[2] Qin Zhang,Ping Gong. Advancements in receptor activity-modifying protein-1 for osteogenesis [J]. Inter J Stomatol, 2019, 46(1): 30-36.
[3] Tingting Li,Yufeng Zhang,Ruoxi Wang,Zhiqing Huang,Lü Xie,Yifan Xue,Yulan Wang. Mechanism and application of osteogenesis induced by graphene and its derivatives modified composite materials [J]. Inter J Stomatol, 2018, 45(6): 673-677.
[4] Zhang Jiankang, Wei Junjun, Tang Zhaolong, Yu Yunbo, Jing Wei. Regulation of Wnt and Notch signaling pathways in the osteogenic differentiation of bone marrow-derived mesen-chymal stem cells from aged individuals [J]. Inter J Stomatol, 2017, 44(4): 459-465.
[5] Hou Liwen, Jiao Ting, Xie Ming. Relationship between vascular endothelial growth factor and tooth occurrence development [J]. Inter J Stomatol, 2016, 43(5): 605-609.
[6] Wu Dong, Bao Guanghui. Extracellular signal-regulated kinase 1/2 signal pathway regulates the osteogenic differentiation of periodontal ligament cells [J]. Inter J Stomatol, 2016, 43(3): 268-272.
[7] Yu Liming1, Shen Qingping1, Chen Jinkun2.. Adiponectin and their association with osteogenesis and bone metabolism [J]. Inter J Stomatol, 2015, 42(6): 681-684.
[8] Liu Yi, Chen Jianzhi.. Bone osteoinduction mechanism of Panax notoginseng saponins [J]. Inter J Stomatol, 2015, 42(1): 75-78.
[9] Guo Jing, Gan Kang, Liu Hong.. Polyetheretherketone composite material and its surface-modified osteogenic efficiency [J]. Inter J Stomatol, 2014, 41(4): 436-439.
[10] Luo Qixian, Liu Changgeng. Distraction osteogenesis of periodontal ligament and dentoalveolar bone acceleration in orthodontic tooth movement [J]. Inter J Stomatol, 2014, 41(3): 309-313.
[11] Zhao Jinglei, Jiang Lingyong, Fang Bing.. Role of forkhead box O1 in bone remodeling [J]. Inter J Stomatol, 2014, 41(2): 245-249.
[12] Huang Wu, Zeng Rongsheng.
Research progress on ultrasound applied to distraction osteogenesis
[J]. Inter J Stomatol, 2013, 40(2): 188-191.
[13] Wang Jinjuan, Chen Jun. . Complications and preventation of distraction osteogenesis in oral and maxillofacial surgery [J]. Inter J Stomatol, 2012, 39(6): 818-823.
[14] Zhang Xiaodan, Hu Danqing, Ping Feiyun.. Alveolar distraction osteogenesis vs. vertical guided bone regeneration for the correction of vertical bone deficiency [J]. Inter J Stomatol, 2012, 39(2): 190-193.
[15] Yu Ruixue1, Wang Dawei1, Chen Yiyang2.. Research progress on distraction osteogenesis in treatment of cleft palate deformities [J]. Inter J Stomatol, 2012, 39(2): 180-183.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .