Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (1): 120-126.doi: 10.7518/gjkq.2023015

• Reviews • Previous Articles    

Research progress on the regulation of bone remodeling by macrophage-derived exosomes

Liu Yi(),Liu Yi.()   

  1. Dept. of Orthodontics, The Affiliated Hospital of Stomatology, China Medical University, Shenyang 110013, China
  • Received:2022-06-06 Revised:2022-10-17 Online:2023-01-01 Published:2023-01-09
  • Contact: Yi Liu,Yi. Liu E-mail:liuyi@cmu.edu.cn;yliu@cmu.edu.cn
  • Supported by:
    Liaoning Province Key Research and Development Plan Project(2020JH2/10300038)

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Abstract:

Macrophages are the major components of human innate immunity and are closely related to bone tissue. Exosomes are nanoscale vesicles released by all cells, thus carrying nucleic acid and other information from the source cells to organize the function of target cells. Studies have demonstrated that macrophage-derived exosomes can effectively regulate bone remodeling, modulate the microenvironment in a variety of ways, and then affect osteogenesis. This paper summarizes the research progress onthe effect of macrophage-derived exosomes on bone remodeling to provide a reference for the development of therapeutic strategies.

Key words: macrophages, exosome, bone remodeling, inflammation

CLC Number: 

  • R 783.5

TrendMD: 

Fig 1

The regulation of M1 macrophages-derived exosomes on the signal pathway of bone remodeling"

Fig 2

The regulation of M2 macrophages-derived exosomes on the signal pathway of bone remodeling"

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