Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (4): 483-488.doi: 10.7518/gjkq.2022045

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Research progress on the stem cells from human exfoliated deciduous teeth in the regeneration and repair of oral tissue

Li Pei(),Lin Ling,Zhao Wei.()   

  1. Dept. of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2021-12-23 Revised:2022-04-06 Online:2022-07-01 Published:2022-06-28
  • Contact: Wei. Zhao E-mail:lipei25@mail2.sysu.edu.cn;zhaowei3@mail.sysu.edu.cn
  • Supported by:
    National Natural Sciences Foundation of China(81974146)

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Abstract:

Stem cells from human exfoliated deciduous teeth (SHEDs) are a kind of dental stem cells extracted from the residual pulp of deciduous teeth. They are easy to obtain, store, and culture and have excellent self-renewal as well as multidirectional differentiation. SHEDs have obvious advantages compared with other mesenchymal stem cells. In recent studies, stem cell therapy using SHEDs has achieved good results in the regeneration and repair of a variety of oral tissues. This article describes the stemness maintenance and differentiation regulation of SHEDs and their advantages in stem cell therapy. Moreover, it reviews the research progress on SHEDs in pulp-dentin complex regeneration, periodontal tissue regeneration, bone regeneration, neuroprotection, and immune regulation.

Key words: stem cell from human exfoliated deciduous teeth, stem cell therapy, tissue regeneration, osteoanage-nesis

CLC Number: 

  • Q 254

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