Int J Stomatol ›› 2022, Vol. 49 ›› Issue (1): 116-120.doi: 10.7518/gjkq.2022007

• Orginal Article • Previous Articles     Next Articles

Research progress on the osteoprotegerin/receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand signaling pathway of tooth eruption

An Ning1(),Li Jiao2,Mei Zhidan1()   

  1. 1. Dept. of Head and Neck Surgery, Hubei Cancer Hospital, Wuhan 430079, China
    2. Dept. of Stomatology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hosptial), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China;;
  • Online:2022-01-01 Published:2022-01-07
  • Contact: Zhidan Mei E-mail:anning0202@qq.com;52213726@qq.com

Abstract:

Tooth eruption is a series of complicated and orderly physiological processes controlled by the dental germ, the alveolar bone, multiple cytokines, and multiple signaling pathways. In the tooth eruption processes, the dental germ moves toward the occasion plane and through the alveolar bone and the oral mucosa, until it finally reaches its functional position, which depends on the presence of osteoclasts. Moreover, the osteoprotegerin/receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand (OPG/RANK/RANKL) signal pathway manipulates the alveolar remo-deling by regulating the differentiation and maturation of osteoclasts. This process may certify that among the tooth, the alveolar could be absorbed normally. However, the exact mechanism underlying tooth eruption remains unclear. Hence, this review describes the recent research progress on the OPG/RANK/RANKL signaling pathway of tooth eruption.

Key words: tooth eruption, osteoclast, osteoprotegerin, receptor activator of nuclear factor-κB ligand, receptor activator of nuclear factor-κB


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