Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (5): 549-555.doi: 10.7518/gjkq.2021084

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Research progress on parathyroid hormone-related protein modulating mandibular condylar cartilage

Xu Lin(),Wang Ruyi,Gou Xinrui,Wang Xiaoli,Li Yu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-01 Revised:2021-05-26 Online:2021-09-01 Published:2021-09-10
  • Contact: Yu Li E-mail:2018224035202@stu.scu.edu.cn;yuli@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(31971247)

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Abstract:

Mandibular condylar cartilage (MCC), different from other articular cartilages of the body, belongs to secondary fibrocartilage and is an important component of the temporomandibular joint. MCC constantly experiences reconstruction, responds to mechanical stimulation, and may degenerate with age due to the particularity of the mastication function of mandible with teeth. Parathyroid hormone-related protein (PTHrP), first discovered in malignant humoral hypercalcemia, regulates bone metabolism by paracrine or autocrine in many tissues. PTHrP plays a role in the development, remolding, and degeneration of MCC. This study reviews the research progress of PTHrP on MCC, which can provide new ideas for the research of PTHrP on the orthodontic functional treatment and repair and regeneration of the temporomandibular joint.

Key words: mandibular condylar cartilage, parathyroid hormone-related protein, cartilage remolding, mechanical stimulation

CLC Number: 

  • R34

TrendMD: 

Fig 1

Schematic diagram of mandibular condylar cartilage"

Fig 2

Illustration of mechanism of Ihh-PTHrP axis on the proliferation and hypertrophy of mandibular condylar cartilage cells"

Fig 3

Illustration of changes of PTHrP in normal TMJ and TMJ-OA"

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