Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (1): 23-28.doi: 10.7518/gjkq.2021006

• Periodontitis • Previous Articles     Next Articles

Research progress on the effects and mechanisms of Porphyromonas gingivalis on vascular endothelial cells from different tissues

Lei Shuang1,Yu Jingjun2,Tang Xiaolin2()   

  1. 1. Dept. of Pediatric Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110001, China
    2. Dept. of Perio-dontology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110001, China
  • Received:2020-06-12 Revised:2020-09-13 Online:2021-01-01 Published:2021-01-20
  • Contact: Xiaolin Tang E-mail:xltang@cmu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81670999)

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Abstract:

Porphyromonas gingivalis is a key putative pathogen in chronic periodontitis. P. gingivalis can adhere, invade and injure vascular endothelial cells and enter the distant organs and tissues, by which P. gingivalis can participate in the onset and progress of systemic diseases such as atherosclerosis and Alzheimer s disease. However, recent studies have found that P. gingivalis has distinct pathogenicity and mechanism to vascular endothelial cells from different tissues. This paper reviews the research progress on the effects and mechanisms of P. gingivalis on vascular endothelial cells from different tissues and aims to broaden the view on the research of P. gingivalis with systemic diseases.

Key words: Porphyromonas gingivalis, vascular endothelial cell, glomerular endothelial cells, blood-brain barrier


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