Int J Stomatol ›› 2021, Vol. 48 ›› Issue (1): 12-17.doi: 10.7518/gjkq.2021004

• Periodontitis • Previous Articles     Next Articles

Role of endoplasmic reticulum stress in periodontitis affecting systemic diseases

Li Xin,Li Yan,Ding Xu,Xia Boyuan,Yu Weixian()   

  1. Dept. of Periodontics, Hospital of Stomatology, Jilin University & Jilin Provincial Key Labo-ratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2020-05-21 Revised:2020-08-13 Online:2021-01-01 Published:2021-01-20
  • Contact: Weixian Yu E-mail:yu-wei-xian@163.com
  • Supported by:
    This study was supported by International Cooperation Project of Science and Technology Development Plan of Jilin Province Science and Technology Department(20180414053GH);Natural Science Foundation of Jilin Province Science and Technology Department(20190201058JC);Science and Technology Project of Jilin Provincial Department of Finance(JCSZ2019378-1)

Abstract:

Periodontitis is a chronic infectious disease that occurs in periodontal tissues, and its pathogenesis and effects on the system have been a hot issue in academic circles. Many scholars have shown that periodontitis is not only a common oral disease, but also a potential risk factor for systemic diseases. However, the mechanism of systemic diseases induced by periodontal disease is still unclear, which may be related to periodontal pathogens, inflammatory factors and endoplasmic reticulum stress. In recent years, studies have found that endoplasmic reticulum stress is an important pathway that mediates apoptosis and is closely related to systemic diseases. Some studies have shown that endoplasmic reticulum stress plays a regulatory role in the process of systemic diseases induced by periodontitis. However, few studies on the role of endoplasmic reticulum stress in periodontitis affecting systemic diseases have been found, and further exploration is needed. This article reviews the research progress of endoplasmic reticulum stress in periodontitis affecting systemic diseases and aims to explore the internal relationship between periodontitis and systemic diseases and provide new ideas for the prevention and treatment of periodontitis and its related systemic diseases.

Key words: periodontitis, endoplasmic reticulum stress, systemic disease

CLC Number: 

  • R782.2

TrendMD: 
[1] Gundamaraju R, Vemuri R, Chong WC , et al. Bilirubin attenuates ER stress-mediated inflammation, escalates apoptosis and reduces proliferation in the LS174T colonic epithelial cell line[J]. Int J Med Sci, 2019,16(1):135-144.
doi: 10.7150/ijms.29134 pmid: 30662337
[2] Pan WY, Wang QX, Chen QM . The cytokine network involved in the host immune response to periodontitis[J]. Int J Oral Sci, 2019,11(3):30.
doi: 10.1038/s41368-019-0064-z pmid: 31685798
[3] Ishida N, Ishihara Y, Ishida K , et al. Periodontitis induced by bacterial infection exacerbates features of Alzheimer s disease in transgenic mice[J]. NPJ Aging Mech Dis, 2017,3:15.
doi: 10.1038/s41514-017-0015-x pmid: 29134111
[4] Mendonça DD, Furtado MV, Sarmento RA , et al. Periodontitis and tooth loss have negative impact on dietary intake: a cross-sectional study with stable co-ronary artery disease patients[J]. J Periodontol, 2019,90(10):1096-1105.
doi: 10.1002/JPER.19-0036 pmid: 31049952
[5] Nascimento GG, Leite FRM, Vestergaard P , et al. Does diabetes increase the risk of periodontitis? A systematic review and Meta-regression analysis of longitudinal prospective studies[J]. Acta Diabetol, 2018,55(7):653-667.
doi: 10.1007/s00592-018-1120-4 pmid: 29502214
[6] Aoyama N, Suzuki JI, Kumagai H , et al. Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients[J]. Heart Vessels, 2018,33(2):198-204.
doi: 10.1007/s00380-017-1042-z pmid: 28803419
[7] Wangerin C, Pink C, Endlich K , et al. Long-term association of periodontitis with decreased kidney fun-ction[J]. Am J Kidney Dis, 2019,73(4):513-524.
doi: 10.1053/j.ajkd.2018.10.013 pmid: 30704881
[8] Cueno ME, Ochiai K . Gingival periodontal disease (PD) level-butyric acid affects the systemic blood and brain organ: insights into the systemic inflammation of periodontal disease[J]. Front Immunol, 2018,9:1158.
doi: 10.3389/fimmu.2018.01158 pmid: 29915575
[9] Xu YM, Melo-Cardenas J, Zhang YN , et al. The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response[J]. JCI Insight, 2019,4(5):121887.
doi: 10.1172/jci.insight.121887 pmid: 30843874
[10] Ochoa CD, Wu RF, Terada LS . ROS signaling and ER stress in cardiovascular disease[J]. Mol Aspects Med, 2018,63:18-29.
doi: 10.1016/j.mam.2018.03.002 pmid: 29559224
[11] Chipurupalli S, Kannan E, Tergaonkar V , et al. Hypoxia induced ER stress response as an adaptive me-chanism in cancer[J]. Int J Mol Sci, 2019,20(3):E749.
doi: 10.3390/ijms20030749 pmid: 30754624
[12] Woo CW, Cui DY, Arellano J , et al. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling[J]. Nat Cell Biol, 2009,11(12):1473-1480.
doi: 10.1038/ncb1996 pmid: 19855386
[13] Yan MJ, Shu SQ, Guo CY , et al. Endoplasmic Reticulum stress in ischemic and nephrotoxic acute kidney injury[J]. Ann Med, 2018,50(5):381-390.
doi: 10.1080/07853890.2018.1489142 pmid: 29895209
[14] Yoshida H . ER stress and diseases[J]. FEBS J, 2007,274(3):630-658.
doi: 10.1111/j.1742-4658.2007.05639.x pmid: 17288551
[15] Inagi R . Endoplasmic reticulum stress as a progression factor for kidney injury[J]. Curr Opin Pharmacol, 2010,10(2):156-165.
doi: 10.1016/j.coph.2009.11.006 pmid: 20045381
[16] Guzel E, Arlier S, Guzeloglu-Kayisli O , et al. Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology[J]. Int J Mol Sci, 2017,18(4):792.
[17] Cybulsky AV . Endoplasmic Reticulum stress, the unfolded protein response and autophagy in kidney diseases[J]. Nat Rev Nephrol, 2017,13(11):681-696.
doi: 10.1038/nrneph.2017.129 pmid: 28970584
[18] Chen YN, Brandizzi F . IRE1: ER stress sensor and cell fate executor[J]. Trends Cell Biol, 2013,23(11):547-555.
doi: 10.1016/j.tcb.2013.06.005 pmid: 23880584
[19] Li YR, Jiang WY, Niu QN , et al. eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apo-ptosis and inflammation and support the proliferation of Newcastle disease virus[J]. Cell Death Dis, 2019,10(12):891.
doi: 10.1038/s41419-019-2128-6 pmid: 31767828
[20] Tam AB, Roberts LS, Chandra V , et al. The UPR activator ATF6 responds to proteotoxic and lipotoxic stress by distinct mechanisms[J]. Dev Cell, 2018, 46(3): 327-343. e7.
doi: 10.1016/j.devcel.2018.04.023 pmid: 30086303
[21] Li YM, Guo YS, Tang J , et al. New insights into the roles of CHOP-induced apoptosis in ER stress[J]. Acta Biochim Biophys Sin (Shanghai), 2015,47(2):146-147.
[22] 薛芃, 李蓓, 谈珺 , 等. 脂多糖诱导的内质网应激在牙周膜干细胞中的表达及其对成骨分化的影响[J]. 中华口腔医学杂志, 2015,50(9):548-553.
Xue P, Li B, Tan J , et al. Effect of endoplasmic reti-culum stress on the expression and osteogenic diffe-rentiation of periodontal ligament stem cells[J]. Chin J Stomatol, 2015,50(9):548-553.
[23] Lee SI, Kang KL, Shin SI , et al. Endoplasmic Reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells[J]. J Periodont Res, 2012,47(3):299-308.
[24] Bai YD, Wei Y, Wu L , et al. C/EBP β mediates endoplasmic Reticulum stress regulated inflammatory response and extracellular matrix degradation in LPS-stimulated human periodontal ligament cells[J]. Int J Mol Sci, 2016,17(3):385.
[25] Yao SQ, Zhao W, Ou QM , et al. MicroRNA-214 suppresses osteogenic differentiation of human periodontal ligament stem cells by targeting ATF4[J]. Stem Cells Int, 2017,2017:3028647.
doi: 10.1155/2017/3028647 pmid: 29213288
[26] Yamada H, Nakajima T, Domon H , et al. Endoplasmic Reticulum stress response and bone loss in experimental periodontitis in mice[J]. J Periodont Res, 2015,50(4):500-508.
[27] Kim DS, Li B, Rhew KY , et al. The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts[J]. Arch Pharm Res, 2012,35(7):1269-1278.
doi: 10.1007/s12272-012-0718-2 pmid: 22864750
[28] Xue P, Li B, An Y , et al. Decreased MORF leads to prolonged endoplasmic Reticulum stress in periodontitis-associated chronic inflammation[J]. Cell Death Differ, 2016,23(11):1862-1872.
doi: 10.1038/cdd.2016.74 pmid: 27447113
[29] Vasconcelos DF, Pereira da Silva FR, Pinto ME, et al. Decrease of pericytes is associated with liver disease caused by ligature-induced periodontitis in rats[J]. J Periodontol, 2017,88(2):e49-e57.
[30] Mealey BL, Oates TW . Diabetes mellitus and periodontal diseases[J]. J Periodontol, 2006,77(8):1289-1303.
[31] Suh JS, Kim S, Boström KI , et al. Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial-mesenchymal transition in mice[J]. Int J Oral Sci, 2019,11(3):21.
[32] Gulle K, Akpolat M, Kurcer Z , et al. Multi-organ injuries caused by lipopolysaccharide-induced perio-dontal inflammation in rats: role of melatonin[J]. J Periodont Res, 2014,49(6):736-741.
[33] Wang H, Chen L, Zhang X , et al. Kaempferol protects mice from d-GalN/LPS-induced acute liver fai-lure by regulating the ER stress-Grp78-CHOP signaling pathway[J]. Biomed Pharmacother, 2019,111:468-475.
[34] Fujita M, Kuraji R, Ito H , et al. Histological effects and pharmacokinetics of lipopolysaccharide derived from Porphyromonas gingivalis on rat maxilla and liver concerning with progression into non-alcoholic steatohepatitis[J]. J Periodontol, 2018,89(9):1101-1111.
pmid: 29799627
[35] Tomofuji T, Ekuni D, Yamanaka R , et al. Chronic administration of lipopolysaccharide and proteases induces periodontal inflammation and hepatic steatosis in rats[J]. J Periodontol, 2007,78(10):1999-2006.
doi: 10.1902/jop.2007.070056 pmid: 17916001
[36] Shi T, Song WF, Xu RL . Autophagy and ER stress in LPS/GalN-induced acute liver injury[J]. Mol Med Rep, 2017,16(5):7001-7005.
pmid: 28901440
[37] Wen JJ, Lin HF, Zhao MS , et al. Piceatannol attenuates D-GalN/LPS-induced hepatoxicity in mice: involvement of ER stress, inflammation and oxidative stress[J]. Int Immunopharmacol, 2018,64:131-139.
doi: 10.1016/j.intimp.2018.08.037 pmid: 30173053
[38] Rachdaoui N . Insulin: the friend and the foe in the development of type 2 diabetes mellitus[J]. Int J Mol Sci, 2020,21(5):E1770.
[39] Laybutt DR, Preston AM, Akerfeldt MC , et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes[J]. Diabetologia, 2007,50(4):752-763.
pmid: 17268797
[40] Hagiwara S, Iwasaka H, Shingu C , et al. Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharide-induced endoplasmic Reticulum stress[J]. Int J Hyperthermia, 2009,25(8):626-633.
[41] Hu YM, Liu J, Yuan Y , et al. Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pa-thway of endoplasmic Reticulum stress[J]. Environ Toxicol Pharmacol, 2018,64:112-121.
doi: 10.1016/j.etap.2018.09.002 pmid: 30342372
[42] Domon H, Takahashi N, Honda T , et al. Up-regulation of the endoplasmic reticulum stress-response in periodontal disease[J]. Clin Chim Acta, 2009,401(1/2):134-140.
[43] Allagnat F, Christulia F, Ortis F , et al. Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis[J]. Diabetologia, 2010,53(6):1120-1130.
pmid: 20349222
[44] Ghosh R,Colon-Negron K, Papa FR. Endoplasmic Reticulum stress, degeneration of pancreatic islet β-cells, therapeutic modulation of the unfolded protein response in diabetes[J]. Mol Metab, 2019, 27-S:S60-S68.
[45] Liu MQ, Chen Z, Chen LX . Endoplasmic Reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases[J]. Acta Pharmacol Sin, 2016,37(4):425-443.
[46] Pedruzzi E, Guichard C, Ollivier V , et al. NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic Reticulum stress and apoptosis in human aortic smooth muscle cells[J]. Mol Cell Biol, 2004,24(24):10703-10717.
[47] Chen J, Zhang MH, Zhu MM , et al. Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway[J]. Food Funct, 2018,9(4):2386-2397.
pmid: 29594285
[48] Hirasawa M, Kurita-Ochiai T . Porphyromonas gingivalis induces apoptosis and autophagy via ER stress in human umbilical vein endothelial cells[J]. Mediators Inflamm, 2018,2018:1967506.
[1] Fu Yu, He Wei, Huang Lan. Ferroptosis and its implication in oral diseases [J]. Int J Stomatol, 2024, 51(1): 36-44.
[2] Luo Xiaojie,Wang Dexu,Chen Xiaotao. Relationship between periodontitis and ferroptosis based on bioinformatics analysis [J]. Int J Stomatol, 2023, 50(6): 661-668.
[3] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[4] Hu Jia,Wang Xiuqing,Lu Guoying,Huang Xiaojing.. Regenerative endodontic procedures for permanent tooth with immature apices in adult patients [J]. Int J Stomatol, 2023, 50(6): 686-695.
[5] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[6] Xu Zhibo,Meng Xiuping.. Research progress on mechanism of Enterococcus faecalis escaping host immune defense [J]. Int J Stomatol, 2023, 50(5): 613-617.
[7] Sun Jia,Han Ye,Hou Jianxia. Research progress on the role of interleukin-6-hepcidin signal axis in regulating the pathogenesis of periodontitis-associated anemia [J]. Int J Stomatol, 2023, 50(3): 329-334.
[8] Liang Zhiying,Zhao Yuanxi,Zhu Jiani,Su Qin.. Retrospective analysis of clinical data of 288 cases of endodontic microsurgery on anterior teeth [J]. Int J Stomatol, 2023, 50(2): 166-171.
[9] Liu Tiqian,Liang Xing,Liu Weiqing,Li Xiaohong,Zhu Rui.. Research progress on the role and mechanism of occlusal trauma in the development of periodontitis [J]. Int J Stomatol, 2023, 50(1): 19-24.
[10] Li Qiong,Yu Weixian. Research progress on resveratrol for the treatment of periodontitis and its bioavailability [J]. Int J Stomatol, 2023, 50(1): 25-31.
[11] Huang Weikun,Xu Qiuyan,Zhou Ting.. Role of baicalin and mechanisms through which baicalin attenuates oxidative stress injury induced by lipopolysaccharide on macrophages [J]. Int J Stomatol, 2022, 49(5): 521-528.
[12] Zhou Jianpeng,Xie Xudong,Zhao Lei,Wang Jun.. Research progress on the roles and mechanisms of T-helper 17 cells and interleukin-17 in periodontitis [J]. Int J Stomatol, 2022, 49(5): 586-592.
[13] Chen Huiyu,Bai Mingru,Ye Ling.. Progress in understanding the correlations between semaphorin 3A and common oral diseases [J]. Int J Stomatol, 2022, 49(5): 593-599.
[14] Zhou Jiajia,Zhao Lei,Xu Xin. Research progress on the genetic polymorphism of periodontitis [J]. Int J Stomatol, 2022, 49(4): 432-440.
[15] Zhu Jiani,Su Qin. Research status of the use of root canal and periapical microflora in refractory periapical periodontitis [J]. Int J Stomatol, 2022, 49(3): 283-289.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .