Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (3): 263-269.doi: 10.7518/gjkq.2020033

• Mesenchymal Stem Cell • Previous Articles     Next Articles

Research progress on N6-methyladenosine for regulating the osteogenic differentiation of bone marrow mesenchymal stem cells

Liu Junqi,Chen Yiyin,Yang Wenbin()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-08-13 Revised:2019-11-29 Online:2020-05-01 Published:2020-05-08
  • Contact: Wenbin Yang E-mail:yangwenbinkq@163.com
  • Supported by:
    Research and Development Foundation of West China Hospital of Stomatology, Sichuan University(RD-02-201907)

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Abstract:

RNA N6-methylation of adenosine is the most prevalent epigenetic modification of messenger and noncoding RNAs in eukaryotes and plays an important role in various biological processes. Recent studies demonstrated that RNA N6-methyladenosine has profound effect on bone marrow mesenchymal stem cell differentiation, especially in osteogenic differentiation. In this paper, we review related studies to provide new strategies for follow-up basic research and clinical applications.

Key words: N 6-methyladenosine, RNA modification, osteogenic differentiation, mesenchymal stem cell

CLC Number: 

  • Q254

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