Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 51-57.doi: 10.7518/gjkq.2020030

• Oral Medicine • Previous Articles     Next Articles

Research progress on oral lichenois lesions

Chen Yuxin,Zhou Yu(),Chen Qianming   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-03-19 Revised:2019-09-28 Online:2020-01-01 Published:2020-01-01
  • Contact: Yu Zhou E-mail:812471898@qq.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81470747);This study was supported by National Natural Science Foundation of China(81771086)

CLC Number: 

  • R781.5

TrendMD: 

Tab 1

Identification of OLP and OLL"

项目 OLP OLL
病因 病因不明,可能与免疫因素、精神因素、内分泌因素、感染因素、微循环障碍因素、遗传因素、糖尿病等相关 汞合金修复体及其他口腔接触材料;某些药物;移植物抗宿主病等
发病机制 T细胞介导的免疫反应 迟发型超敏反应
组织病理 上皮过度不全角化;基底细胞液化变性;固有层密集的淋巴细胞呈带状浸润 上皮局灶性角化不全;淋巴细胞可弥漫性浸润于固有层及黏膜下层;炎症细胞有向血管聚集的趋势
免疫病理 基底膜区纤维蛋白原强荧光带 基底膜区弱而均一线性荧光染色
临床表现 通常双侧对称发生;可发生于口腔黏膜任何部位,以颊部最为多见 通常单侧发生;常多发于金属修复体邻近部位
潜在恶变性[45,49,66] 0.4%~2%[67] 2.1%~2.5%
治疗 心理治疗;药物治疗;手术治疗;光动力疗法 着重明确并去除可疑致病因素,余治疗手段同OLP
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