Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (2): 146-151.doi: 10.7518/gjkq.2020020

• Periodontitis • Previous Articles     Next Articles

Research progress of exosomes derived from different stem cells in periodontal regeneration

Wu Xiaonan1,Ma Ning2,Hou Jianxia3()   

  1. 1. Dept. of Periodontology, Qingdao Stomatological Hospital, Qingdao 266001, China
    2. Dept. of Stomatology, Qingdao Municipal Hospital, Qingdao 266071, China
    3. Dept. of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China
  • Received:2019-06-04 Revised:2019-11-29 Online:2020-03-01 Published:2020-03-12
  • Contact: Jianxia Hou E-mail:jxhou@163.com
  • Supported by:
    This study was supported by Qingdao Health Science and Technology Development(2017-WJZD123)

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Abstract:

Periodontitis is a chronic infectious disease caused by dental plaque and the primary reason for tooth loss in adults because it damages periodontal supporting structures. Microbial plaque biofilm control is an effective method to prevent further disease progression. However, a reliable treatment that can lead to stable and satisfactory periodontal regeneration in clinical practice has not been reported to date. Exosome is a specific class of lipid-membrane-bound extracellular vesicle. Exosomes are secreted from cells through paracrine mechanism and participate in tissue regeneration. Considering that the application of exosomes provides a new strategy for tissue regeneration, this review presents the current status of exosomes derived from different kinds of cells for potential therapeutic use in periodontal regeneration.

Key words: exosome, periodontal regeneration, mesenchymal stem cell

CLC Number: 

  • Q756

TrendMD: 
[1] Han J, Menicanin D, Gronthos S , et al. Stem cells, tissue engineering and periodontal regeneration[J]. Aust Dent J, 2014,59(Suppl 1):117-130.
[2] Vizoso FJ, Eiro N, Cid S , et al. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine[J]. Int J Mol Sci, 2017,18(9). doi: 10.3390/ijms18091852.
[3] Veneruso V, Rossi F, Villella A , et al. Stem cell para-crine effect and delivery strategies for spinal cord injury regeneration[J]. J Control Release, 2019,300:141-153.
[4] Park SR, Kim JW, Jun HS , et al. Stem cell secretome and its effect on cellular mechanisms relevant to wound healing[J]. Mol Ther, 2018,26(2):606-617.
[5] Johnstone RM, Adam M, Hammond JR , et al. Vesicle formation during reticulocyte maturation. Associa-tion of plasma membrane activities with released vesicles (exosomes)[J]. J Biol Chem, 1987,262(19):9412-9420.
[6] Jing H, He X, Zheng J . Exosomes and regenerative medicine: state of the art and perspectives[J]. Transl Res, 2018,196:1-16.
[7] Skotland T, Sandvig K, Llorente A . Lipids in exoso-mes: current knowledge and the way forward[J]. Prog Lipid Res, 2017,66:30-41.
[8] Rana S, Yue S, Stadel D , et al. Toward tailored exo-somes: the exosomal tetraspanin web contributes to target cell selection[J]. Int J Biochem Cell Biol, 2012,44(9):1574-1584.
[9] Vabulas RM, Raychaudhuri S, Hayer-Hartl M , et al. Protein folding in the cytoplasm and the heat shock response[J]. Cold Spring Harb Perspect Biol, 2010,2(12):a004390.
[10] Conde-Vancells J, Rodriguez-Suarez E, Embade N , et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes[J]. J Proteome Res, 2008,7(12):5157-5166.
[11] Cobelli NJ, Leong DJ, Sun HB . Exosomes: biology, therapeutic potential, and emerging role in muscu-loskeletal repair and regeneration[J]. Ann N Y Acad Sci, 2017,1410(1):57-67.
[12] Kadota T, Yoshioka Y, Fujita Y , et al. Extracellular vesicles in lung cancer—from bench to bedside[J]. Semin Cell Dev Biol, 2017,67:39-47.
[13] Koppers-Lalic D, Hogenboom MM, Middeldorp JM , et al. Virus-modified exosomes for targeted RNA delivery; a new approach in nanomedicine[J]. Adv Drug Deliv Rev, 2013,65(3):348-356.
[14] Li X, Corbett AL, Taatizadeh E , et al. Challenges and opportunities in exosome research—perspec-tives from biology, engineering, and cancer therapy[J]. APL Bioeng, 2019,3(1):011503.
[15] Villarroya-Beltri C, Baixauli F, Mittelbrunn M , et al. ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins[J]. Nat Commun, 2016,7:13588.
[16] Song L, Tang S, Han X , et al. KIBRA controls exo-some secretion via inhibiting the proteasomal de-gradation of Rab27a[J]. Nat Commun, 2019,10(1):1639.
[17] Hyenne V, Apaydin A, Rodriguez D , et al. RAL-1 controls multivesicular body biogenesis and exosome secretion[J]. J Cell Biol, 2015,211(1):27-37.
[18] Chen C, Wang D, Moshaverinia A , et al. Mesen-chymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis[J]. Cell Res, 2017,27(4):559-577.
[19] Lu Z, Chen Y, Dunstan C , et al. Priming adipose stem cells with tumor necrosis factor-alpha preconditio-ning potentiates their exosome efficacy for bone regeneration[J]. Tissue Eng Part A, 2017,23(21/22):1212-1220.
[20] Narayanan K, Kumar S, Padmanabhan P , et al. Lineage-specific exosomes could override extra-cellular matrix mediated human mesenchymal stem cell differentiation[J]. Biomaterials, 2018,182:312-322.
[21] Cui Y, Luan J, Li H , et al. Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expre-ssion[J]. FEBS Lett, 2016,590(1):185-192.
[22] Narayanan R, Huang CC, Ravindran S . Hijacking the cellular mail: exosome mediated differentiation of mesenchymal stem cells[J]. Stem Cells Int, 2016,2016:3808674.
[23] Li XL, Liu YB, Ma EG , et al. Synergistic effect of BMP9 and TGF-β in the proliferation and differen-tiation of osteoblasts[J]. Genet Mol Res, 2015,14(3):7605-7615.
[24] Lamplot JD, Qin J, Nan G , et al. BMP9 signaling in stem cell differentiation and osteogenesis[J]. Am J Stem Cells, 2013,2(1):1-21.
[25] Zhang J, Liu X, Li H , et al. Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway[J]. Stem Cell Res Ther, 2016,7(1):136.
[26] Qi X, Zhang J, Yuan H , et al. Exosomes secreted by human-induced pluripotent stem cell-derived me-senchymal stem cells repair critical-sized bone de-fects through enhanced angiogenesis and osteogenesis in osteoporotic rats[J]. Int J Biol Sci, 2016,12(7):836-849.
[27] Li W, Liu Y, Zhang P , et al. Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration[J]. ACS Appl Mater Interfaces, 2018,10(6):5240-5254.
[28] Seo BM, Miura M, Gronthos S , et al. Investigation of multipotent postnatal stem cells from human pe-riodontal ligament[J]. Lancet, 2004,364(9429):149-155.
[29] 朱斌, 李楠, 田自锋 , 等. 骨髓间充质干细胞来源的外泌体促进牙周再生的体外研究[J]. 中国实用口腔科杂志, 2016,9(12):709-713.
Zhu B, Li N, Tian ZF , et al. Study of periodontal regeneration promoted by exosome from BMMSC in vitro[J]. Chin J Pract Stomatol, 2016,9(12):709-713.
[30] 费栋栋 . 外泌体介导牙周膜干细胞成骨异质性克隆亚群间信息交流的作用及机制研究[D]. 西安: 空军军医大学, 2017.
Fei DD . Exosome mediate communications between PDLSCs-derived single-cell clones with osteogenic heterogeneity: its role and mechanism[D]. Xi’an: Air Force Medical University, 2017.
[31] Mohammed E, Khalil E, Sabry D . Effect of adipose-derived stem cells and their Exo as adjunctive the-rapy to nonsurgical periodontal treatment: a his-tologic and histomorphometric study in rats[J]. Bio-molecules, 2018,8:167.
[32] Chew JRJ, Chuah SJ, Teo KYW , et al. Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration[J]. Acta Biomater, 2019,89:252-264.
[33] Yu B, Zhang X, Li X . Exosomes derived from mesenchymal stem cells[J]. Int J Mol Sci, 2014,15(3):4142-4157.
[34] Vizoso FJ, Eiro N, Cid S , et al. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine[J]. Int J Mol Sci, 2017,18(9). doi: 10.3390/ijms18091852.
[35] Vishnubhatla I, Corteling R, Stevanato L , et al. The development of stem cell-derived exosomes as a cell-free regenerative medicine[J]. J Circ Biomark, 2014,3:2.
[36] Sharma A . Role of stem cell derived exosomes in tumor biology[J]. Int J Cancer, 2018,142(6):1086-1092.
[37] Qi J, Zhou Y, Jiao Z , et al. Exosomes derived from human bone marrow mesenchymal stem cells pro-mote tumor growth through hedgehog signaling pa-thway[J]. Cell Physiol Biochem, 2017,42(6):2242-2254.
[38] Zhang HG, Grizzle WE . Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions[J]. Am J Pathol, 2014,184(1):28-41.
[39] Harris DA, Patel SH, Gucek M , et al. Exosomes released from breast cancer carcinomas stimulate cell movement[J]. PLoS One, 2015,10(3):e0117495.
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