Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (2): 235-243.doi: 10.7518/gjkq.2020013

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Application and research progress on concentrated growth factor in oral clinic

Wei Zhongwu1,Huang Xieshan1(),Chen Zhuogeng2   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Haikou Hospital Affiliated to Xiangya Medical School, Central South University, Haikou 570208, China
    2. Dept. of Dental Implantology, Haikou Hospital Affiliated to Xiangya Medical School, Central South University, Haikou 570208, China
  • Received:2019-05-14 Revised:2019-09-29 Online:2020-03-01 Published:2020-03-12
  • Contact: Xieshan Huang E-mail:hnsun3@126.com
  • Supported by:
    This study was supported by Surface Project of Hainan Natural Science Foundation(818MS138)

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Abstract:

Concentrated growth factor (CGF) is a new generation of platelet concentrate prepared by differential centrifugation. Compared with the two previous generations of platelet concentrates, CGF contains more growth factors in the same volume. It has a fibrin matrix with high tensile strength and viscosity and long application time in the body and exhibits good tissue regeneration ability. CGF has been widely used in oral implant and maxillofacial surgery because of its simple and efficient preparation by autologous blood. Moreover, CGF contains a large number of growth factors that exert an osteoinductive effect and a fibrin matrix that plays a role in bone guidance. Furthermore, CGF can activate angiogenesis and effectively induce and accelerate soft and bone tissue. CGF can also shorten the healing time without the risk of cross-infection and immune rejection and has a certain anti-inflammatory effect. This article reviews the application of CGF in oral cavity and related research progress. We hope to provide a theoretical basis for the further application of CGF in oral clinics.

Key words: concentrated growth factor, oral clinical, research progress

CLC Number: 

  • Q26

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