Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (2): 219-224.doi: 10.7518/gjkq.2020011

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Research progress on shape memory polymers in bone defect repair and regeneration

Liu Yuhao1,Zhang Tao2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-05 Revised:2019-10-25 Online:2020-03-01 Published:2020-03-12
  • Contact: Tao Zhang E-mail:taozhang@scu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81800947);China Postdoctoral Science Foundation(2018M640930);Youth Science Foundation of West China Hospital of Stomatology, Sichuan University(WCHS-201706)

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Abstract:

As novel stimuli-responsive biomaterials, shape memory polymers (SMPs) have been used in bone defect repair. The 3D shape of these biomaterials can be switched between initial and temporary states under external stimuli, such as temperature changes and water contact, making them suitable for tightly filling bone defects and advantageous over traditional materials featuring shape mismatch and complicated implantation. In addition, modified SMPs can be used as porous bone tissue engineering scaffolds to load various bioactive factors and stem cells for new bone formation. Recently, SMPs have shown promising prospects in minimal invasiveness, repairing irregular bone defects, and promoting bone defect regeneration. This review will discuss the current progresses of SMPs in bone tissue engineering, including their mechanism, biological effects, and performance optimization.

Key words: shape memory effect, polymer material, bone defect, bone tissue engineering

CLC Number: 

  • R318.08

TrendMD: 

Fig 1

Diagram of shape memory effect"

[1] Dreifke MB, Ebraheim NA, Jayasuriya AC . Investi-gation of potential injectable polymeric biomaterials for bone regeneration[J]. J Biomed Mater Res A, 2013,101(8):2436-2447.
[2] Tang D, Tare RS, Yang LY , et al. Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration[J]. Biomaterials, 2016,83:363-382.
[3] Zhang DW, George OJ, Petersen KM , et al. A bioactive ‘self-fitting’ shape memory polymer scaffold with potential to treat cranio-maxillo facial bone defects[J]. Acta Biomater, 2014,10(11):4597-4605.
[4] Fernandez-Yague MA, Abbah SA, McNamara L , et al. Biomimetic approaches in bone tissue engineering: integrating biological and physicomechanical strate-gies[J]. Adv Drug Deliv Rev, 2015,84:1-29.
[5] 杨强, 彭江, 卢世璧 , 等. 骨髓基质干细胞与软骨脱细胞基质多孔支架异位构建组织工程化软骨的实验研究[J]. 中华骨科杂志, 2010,30(4):417-422.
Yang Q, Peng J, Lu SB , et al. Fabrication a novel cartilage ECM-derived 3-D porous acellular matrix scafold and in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells[J]. Chin J Orthop, 2010,30(4):417-422.
[6] 邱耿韬, 史占军, 赵亮 . 磷酸钙骨水泥在骨组织再生修复应用中的研究进展[J]. 中国矫形外科杂志, 2013,21(14):1406-1409.
Qiu GT, Shi ZJ, Zhao L . Research progress of calcium phosphate cement in bone tissue regeneration and repair[J]. Orthop J China, 2013,21(14):1406-1409.
[7] Sivashanmugam A, Arun Kumar R, Vishnu Priya M , et al. An overview of injectable polymeric hydrogels for tissue engineering[J]. Eur Polym J, 2015,72:543-565.
[8] Pina S, Oliveira JM, Reis RL . Natural-based nano-composites for bone tissue engineering and regene-rative medicine: a review[J]. Adv Mater Weinheim, 2015,27(7):1143-1169.
[9] Jahan K, Tabrizian M . Composite biopolymers for bone regeneration enhancement in bony defects[J]. Biomater Sci, 2016,4(1):25-39.
[10] 张文晶, 高长有 . 智能响应型聚合物微粒及其与细胞的相互作用[J]. 中国材料进展, 2012,31(5):19-30.
Zhang WJ, Gao CY . Intelligent-responsive polymeric particles and their interactions with cells[J]. Mater China, 2012,31(5):19-30.
[11] Kim DY, Kwon DY, Kwon JS , et al. Stimuli-respon-sive injectable in situ-forming hydrogels for rege-nerative medicines[J]. Polym Rev, 2015,55(3):407-452.
[12] Wu YB, Wang L, Zhao X , et al. Self-healing supra-molecular bioelastomers with shape memory pro-perty as a multifunctional platform for biomedical applications via modular assembly[J]. Biomaterials, 2016,104:18-31.
[13] Hasan SM, Nash LD, Maitland DJ . Porous shape memory polymers: design and applications[J]. J Polym Sci B Polym Phys, 2016,54(14):1300-1318.
[14] Chan BQ, Low ZW, Heng SJ , et al. Recent advances in shape memory soft materials for biomedical ap-plications[J]. ACS Appl Mater Interfaces, 2016,8(16):10070-10087.
[15] Hardy JG, Palma M, Wind SJ , et al. Responsive bio-materials: advances in materials based on shape-memory polymers[J]. Adv Mater Weinheim, 2016,28(27):5717-5724.
[16] Kai D, Prabhakaran MP, Chan BQ , et al. Elastic poly(ε-caprolactone)-polydimethylsiloxane copo-lymer fibers with shape memory effect for bone tissue engineering[J]. Biomed Mater, 2016,11(1):015007.
[17] Rychter P, Pamula E, Orchel A , et al. Scaffolds with shape memory behavior for the treatment of large bone defects[J]. J Biomed Mater Res A, 2015,103(11):3503-3515.
[18] Xie MH, Wang L, Ge J , et al. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering[J]. ACS Appl Mater Interfaces, 2015,7(12):6772-6781.
[19] Bao M, Wang XL, Yuan HH , et al. HAp incorporated ultrafine polymeric fibers with shape memory effect for potential use in bone screw hole healing[J]. J Mater Chem B, 2016,4(31):5308-5320.
[20] Bao M, Lou XX, Zhou QH , et al. Electrospun bio-mimetic fibrous scaffold from shape memory poly-mer of PDLLA-co-TMC for bone tissue engineering[J]. ACS Appl Mater Interfaces, 2014,6(4):2611-2621.
[21] Liu X, Zhao K, Gong T , et al. Delivery of growth factors using a smart porous nanocomposite scaffold to repair a mandibular bone defect[J]. Biomacromo-lecules, 2014,15(3):1019-1030.
[22] Correia CO, Leite ÁJ, Mano JF . Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties[J]. Carbohydr Polym, 2015,123:39-45.
[23] Baker RM, Tseng LF, Iannolo MT , et al. Self-deplo-ying shape memory polymer scaffolds for grafting and stabilizing complex bone defects: a mouse fe-moral segmental defect study[J]. Biomaterials, 2016,76:388-398.
[24] Xie RQ, Hu JL, Hoffmann O , et al. Self-fitting shape memory polymer foam inducing bone regeneration: a rabbit femoral defect study[J]. Biochim Biophys Acta Gen Subj, 2018,1862(4):936-945.
[25] Neffe AT, Hanh BD, Steuer S , et al. Polymer networks combining controlled drug release, biodegradation, and shape memory capability[J]. Adv Mater, 2009,21(32/33):3394-3398.
[26] Lee EM, Smith K, Gall K , et al. Change in surface roughness by dynamic shape-memory acrylate net-works enhances osteoblast differentiation[J]. Bioma-terials, 2016,110:34-44.
[27] Erndt-Marino JD, Munoz-Pinto DJ, Samavedi S , et al. Evaluation of the osteoinductive capacity of polydopamine-coated poly(ε-caprolactone) diacrylate shape memory foams[J]. ACS Biomater Sci Eng, 2015,1(12):1220-1230.
[28] Tseng LF, Wang J, Baker RM , et al. Osteogenic ca-pacity of human adipose-derived stem cells is preser-ved following triggering of shape memory scaf-folds[J]. Tissue Eng Part A, 2016,22(15/16):1026-1035.
[29] Hendrikson WJ, Rouwkema J, Clementi F , et al. Towards 4D printed scaffolds for tissue engineering: exploiting 3D shape memory polymers to deliver time-controlled stimulus on cultured cells[J]. Biofa-brication, 2017,9(3):031001.
[30] Wei Z, Yang JH, Zhou JX , et al. Self-healing gels based on constitutional dynamic chemistry and their potential applications[J]. Chem Soc Rev, 2014,43(23):8114-8131.
[31] Yang B, Zhang YL, Zhang XY , et al. Facilely prepared inexpensive and biocompatible self-healing hydrogel: a new injectable cell therapy carrier[J]. Polym Chem, 2012,3(12):3235-3238.
[32] Wang J, Brasch ME, Baker RM , et al. Shape memory activation can affect cell seeding of shape memory polymer scaffolds designed for tissue engineering and regenerative medicine[J]. J Mater Sci Mater Med, 2017,28(10):151.
[33] Ni PY, Ding QX, Fan M , et al. Injectable thermo-sensitive PEG-PCL-PEG hydrogel/acellular bone matrix composite for bone regeneration in cranial defects[J]. Biomaterials, 2014,35(1):236-248.
[34] Xiao H, Lu W, Le XX , et al. A multi-responsive hy-drogel with a triple shape memory effect based on reversible switches[J]. Chem Commun (Camb), 2016,52(90):13292-13295.
[35] Behl M, Razzaq MY, Lendlein A . Multifunctional shape-memory polymers[J]. Adv Mater, 2010,22(31):3388-3410.
[36] Jung YC, Cho JW . Application of shape memory polyurethane in orthodontic[J]. J Mater Sci Mater Med, 2010,21(10):2881-2886.
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
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[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
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[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .