Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 84-89.doi: 10.7518/gjkq.2020005

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Function of autophagy induced by mammalian target of rapamycin complex 1 in bone metabolism

Zhu Junjin1,Zhou Jiaqi1,Wu Yingying2,()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-12 Revised:2019-10-09 Online:2020-01-01 Published:2020-01-01
  • Contact: Yingying Wu E-mail:yywdentist@163.com
  • Supported by:
    This study was supported by Sichuan Science and Technology Innovation Seedling Project(2018RZ0088)

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Abstract:

The mammalian target of rapamycin (mTOR) forms two functionally distinct multiprotein complexes, one of which is the mammalian target of rapamycin complex 1 (mTORC1). The mTORC1 plays a central role in regulating anabolic processes, including autophagy, which has recently captured extensive attention. Autophagy is an intracellular recycling pathway in which cellular components, including protein aggregates and organelles, are targeted to the lysosome for degradation. In recent years, an increasing amount of evidence shows that autophagy is mediated by mTORC1, which plays a critical role in bone metabolism. This review summarises the important role and mechanism of mTORC1-mediated autophagy in bone-related cells, especially osteoblasts and osteoclasts.

Key words: mammalian target of rapamycin complex, autophagy, osteoblast, osteoclast

CLC Number: 

  • Q251

TrendMD: 
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