Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 76-83.doi: 10.7518/gjkq.2020004

• Reviews • Previous Articles     Next Articles

Research progress on microRNA-mediated mechanisms between periodontitis and atherosclerosis

Zhou Jieyu,Liu Lin,Wu Yafei,Zhao Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-08 Revised:2019-09-12 Online:2020-01-01 Published:2020-01-01
  • Supported by:
    This study was supported by National Natural and Science Foundation of China(81771077);This study was supported by National Natural and Science Foundation of China(81970944);Fund of Science and Technology Department of Sichuan Province(2018SZ01161)

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Abstract:

Periodontitis is a chronic inflammatory disease characterised by destruction of periodontal supporting tissue, which is mainly due to plaque biofilm and host immune response. Periodontal pathogen can invade the blood circulation system by transient bacteraemia and trigger the vascular inflammation, which can definitely increase the risk of cardiovascular disease. MicroRNA, a small molecule RNA discussed in this paper, can regulate gene expression in epigenetics and participate in the regulation of inflammation. This review focuses on the mechanism of how periodontal pathogens regulate immune inflammatory response by microRNA to mediate the generation and development of atherosclerosis, which can provide new ideas for the research on the linkages on molecular mechanism between periodontitis and atherosclerosis. Moreover, exploring the specific microRNA expression patterns related to atherosclerosis and periodontitis can serve as a theoretical basis for the diagnosis and treatment of cardiovascular diseases in the future.

Key words: periodontal pathogen, periodontitis, atherosclerosis, cardiovascular disease, microRNA

CLC Number: 

  • R781.4 +2

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