Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 724-729.doi: 10.7518/gjkq.2019089

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Research progress of erythropoietin-producing hepatocyte kinase receptor and ephrin ligand in alveolar bone remodeling

Wang Linxuan1,Wang Qi1,Zhao Yun1,Mi Fanglin1,2()   

  1. 1. Dept. of Stomatology, North Sichuan Medical College, Nanchong 637000, China
    2. Dept. of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
  • Received:2019-01-05 Revised:2019-06-28 Online:2019-11-01 Published:2019-11-14
  • Contact: Fanglin Mi E-mail:mfl126@126.com
  • Supported by:
    This study was supported by Scientific Research Project of Sichuan Education Department(15ZA0210);Research and Development Fund Project of Nanchong(16YFZJ0123);Science and Technology Strategic Cooperation between City and School of Nanchong(NSMC2017- 0442)

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Abstract:

The erythropoietin producing hepatocyte kinase receptor and ephrin ligand (ephrin/Eph) are new signal pathways associated with bone remodeling in addition to the receptor activator for nuclear factor-κB ligand/receptor activator for nuclear factor-κB/osteoprotegenin (RANKL/RANK/OPG). In alveolar bone remodeling, ephrin/Eph-related factors are not only related to the interaction between bone cells but also affected by periodontal ligament cells. The expression of related factors in the process of alveolar bone tissue remodeling is substantially different from that for normal bone tissue. This difference reveals the complexity and importance of ephrin/Eph-related factors in the regulation of bone remodeling. This study reviews the research progress on the interaction of the ephrin/Eph pathway between bone cells and periodontal ligament cells to participate in alveolar bone remodeling.

Key words: erythropoietin producing hepatocyte kinase receptor, erythropoietin producing hepatocyte kinase ligand, alveolar bone, bone remodeling, periodontal ligament

CLC Number: 

  • Q26

TrendMD: 
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