Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 657-662.doi: 10.7518/gjkq.2019077

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Research progress of protease-activated receptors on different types of cells in periodontal tissue

Lu Kexin1,Zhang Diya2,Wu Yanmin1   

  1. 1. Dept. of Oral Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
    2. Dental Department, The Affiliated Sir Run Shaw Hospital, Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310016, China
  • Received:2019-03-06 Revised:2019-07-14 Online:2019-11-01 Published:2019-11-14
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81000447);Science and Technology Department Public Welfare Research Plan of Zhejiang Province(LGF18H140003);Natural Science Foundation of Zhejiang Province(LY17H140002)

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Abstract: Protease-activated receptors (PARs), which are widely expressed transmembrane proteins, may induce inflammatory response once activated by a variety of endogenous and bacterial enzymes. Gingival epithelial cells, gingival fibroblasts, osteoblasts, osteoclasts, monocytes, macrophages and T lymphocytes exist in the periodontal tissue. In the development of periodontitis, the activated PARs of these cells are involved in the release of inflammatory factors and chemokines that cause gingival inflammation and alveolar bone destruction. Up-to-date data has shown the roles of PAR-1 and PAR-2 in periodontitis. However, the roles of PARs in hinge on different types of cells in the periodontal tissue have not been reviewed. Thus, the present review will focus on the current progress in the expression and functions of PARs.

Key words: protease-activated receptor, gingival epithelial cell, gingival fibroblast, osteoblast, osteoclast

CLC Number: 

  • Q26

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