Int J Stomatol ›› 2019, Vol. 46 ›› Issue (3): 258-262.doi: 10.7518/gjkq.2019033

• Signalling Pathways • Previous Articles     Next Articles

Effects of bone morphogenetic protein signalling pathway and its crosstalks on mandible development

Xiaomeng Wang1,Xiao Wang1,Ce Shi2,3,Hongchen Sun2,3,Yang Huang1()   

  1. 1.Dept. of Pediatric Dentistry, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Dept. of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    3.Key Laboratory of Tooth Development and Bone Remodeling of Jilin Province, Changchun 130021, China
  • Received:2018-04-20 Revised:2019-01-08 Online:2019-05-01 Published:2019-06-05
  • Contact: Yang Huang E-mail:huangyang1960@163.com

Abstract:

Mandible, as the only autonomic movable bone in the craniofacial region, plays multiple important roles, such as chewing, pronunciation and swallowing. Bone morphogenetic protein (BMP) signalling pathway plays a fundamental role in the formation and homeostasis of bone and cartilage and is essential for mandible development. BMP ligands, receptors and downstream cytokines are associated with other signalling pathways, thereby forming a complex and extensive signalling network which regulates mandibular development. This review mainly introduces the roles of BMP signalling and its crosstalks during mandible development.

Key words: bone morphogenetic protein signalling pathway, crosstalk, mandible development

CLC Number: 

  • Q257

TrendMD: 
[1] Parada C, Chai Y . Mandible and tongue development[J]. Curr Top Dev Biol, 2015,115:31-58.
doi: 10.1016/bs.ctdb.2015.07.023
[2] Biosse Duplan M, Komla-Ebri D, Heuzé Y , et al. Meckel’s and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible[J]. Hum Mol Genet, 2016,25(14):2997-3010.
doi: 10.1093/hmg/ddw153 pmid: 5181594
[3] Michigami T . Regulatory mechanisms for the development of growth plate cartilage[J]. Cell Mol Life Sci, 2013,70(22):4213-4221.
doi: 10.1007/s00018-013-1346-9 pmid: 23640571
[4] Sánchez-Duffhues G, Hiepen C, Knaus P , et al. Bone morphogenetic protein signaling in bone homeostasis[J]. Bone, 2015,80:43-59.
doi: 10.1016/j.bone.2015.05.025 pmid: 26051467
[5] Salazar VS, Gamer LW, Rosen V . BMP signalling in skeletal development, disease and repair[J]. Nat Rev Endocrinol, 2016,12(4):203-221.
doi: 10.1038/nrendo.2016.12 pmid: 26893264
[6] Guo X, Wang XF . Signaling cross-talk between TGF- β/BMP and other pathways[J]. Cell Res, 2009,19(1):71-88.
doi: 10.1038/cr.2008.302
[7] Wu M, Chen G, Li YP . TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease[J]. Bone Res, 2016,4:16009.
doi: 10.1038/boneres.2016.9 pmid: 4985055
[8] Rigueur D, Brugger S, Anbarchian T , et al. The type Ⅰ BMP receptor ACVR1/ALK2 is required for chondrogenesis during development[J]. J Bone Miner Res, 2015,30(4):733-741.
doi: 10.1002/jbmr.2385 pmid: 25413979
[9] Feng XY, Zhao YM, Wang WJ , et al. Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture[J]. Eur J Oral Sci, 2013,121(5):412-420.
doi: 10.1111/eos.12078 pmid: 24028588
[10] Tak HJ, Park TJ, Piao Z , et al. Separate development of the maxilla and mandible is controlled by regional signaling of the maxillomandibular junction during avian development[J]. Dev Dyn, 2017,246(1):28-40.
doi: 10.1002/dvdy.24465 pmid: 27756109
[11] Lovely CB, Swartz ME , McCarthy N , et al. Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish[J]. Development, 2016,143(11):2000-2011.
doi: 10.1242/dev.129379 pmid: 27122171
[12] D’Souza RN, Ruest LB, Hinton RJ , et al. Development of the craniofacial complex//Bronner F, Farach-Carson M, Roach H, eds. Bone and development. Topics in bone biology[M]. London: Springer, 2010: 153-181.
[13] Maruyama T, Jiang M, Abbott A , et al. Rap1b is an effector of Axin2 regulating crosstalk of signaling pathways during skeletal development[J]. J Bone Miner Res, 2017,32(9):1816-1828.
doi: 10.1002/jbmr.3171 pmid: 28520221
[14] Shum L, Sakakura Y, Bringas P Jr , et al. EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel’s cartilage during embryonic mouse mandibular morphogenesis in vitro[J]. Development, 1993,118(3):903-917.
doi: 10.3138/9781442685444 pmid: 8076525
[15] Nonaka K, Shum L, Takahashi I , et al. Convergence of the BMP and EGF signaling pathways on Smad1 in the regulation of chondrogenesis[J]. Int J Dev Biol, 1999,43(8):795-807.
doi: 10.1101/gad.13.21.2889 pmid: 10707903
[16] Ling IT, Rochard L, Liao EC . Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification[J]. Dev Biol, 2017,421(2):219-232.
doi: 10.1016/j.ydbio.2016.11.016 pmid: 5266562
[17] Leucht P, Kim JB, Helms JA . Beta-catenin-dependent Wnt signaling in mandibular bone regeneration[J]. J Bone Joint Surg Am, 2008,90(Suppl 1):3-8.
doi: 10.2106/JBJS.G.01136 pmid: 18292349
[18] Hosseini-Farahabadi S, Geetha-Loganathan P, Fu K , et al. Dual functions for WNT5A during cartilage development and in disease[J]. Matrix Biol, 2013,32(5):252-264.
doi: 10.1016/j.matbio.2013.02.005 pmid: 23474397
[19] Luo Q, Kang Q, Si W , et al. Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells[J]. J Biol Chem, 2004,279(53):55958-55968.
doi: 10.1074/jbc.M407810200 pmid: 15496414
[20] Billmyre KK, Klingensmith J . Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation[J]. Dev Dyn, 2015,244(4):564-576.
doi: 10.1002/dvdy.24256 pmid: 25626636
[21] Maes C . Signaling pathways effecting crosstalk between cartilage and adjacent tissues: Seminars in cell and developmental biology: The biology and pathology of cartilage[J]. Semin Cell Dev Biol, 2017,62:16-33.
doi: 10.1016/j.semcdb.2016.05.007
[22] Serrano MJ, So S, Hinton RJ . Roles of notch signalling in mandibular condylar cartilage[J]. Arch Oral Biol, 2014,59(7):735-740.
doi: 10.1016/j.archoralbio.2014.04.003 pmid: 24814170
[23] Shang X, Wang J, Luo Z , et al. Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest[J]. Sci Rep, 2016,6:25594.
doi: 10.1038/srep25594 pmid: 27146698
[24] Oka K, Oka S, Sasaki T , et al. The role of TGF-β signaling in regulating chondrogenesis and osteogenesis during mandibular development[J]. Dev Biol, 2007,303(1):391-404.
doi: 10.1016/j.ydbio.2006.11.025 pmid: 20202020202020202020202020
[25] Majidinia M, Sadeghpour A, Yousefi B . The roles of signaling pathways in bone repair and regeneration[J]. J Cell Physiol, 2018,233(4):2937-2948.
doi: 10.1002/jcp.26042 pmid: 28590066
[26] Li Z, Lu H, Li ZB . The PI3K/Akt signalling pathway may play an internal role related to abnormal condylar growth: a preliminary study[J]. Int J Oral Maxillofac Surg, 2014,43(12):1477-1483.
doi: 10.1016/j.ijom.2014.05.015 pmid: 24929453
[1] PANG Bao -xing, JIN Xiao -ming. Crosstalk between Wnt and Notch signaling pathways and their relationships with o [J]. Inter J Stomatol, 2009, 36(3): 341-343.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .