Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (2): 244-248.doi: 10.7518/gjkq.2019014

• Reviews • Previous Articles    

Research progress on the etiology and therapy of bone defect during dental implantation under diabetic condition

Pengfei Zhao,Qi Wang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-04-09 Revised:2018-10-12 Online:2019-03-01 Published:2019-03-15
  • Contact: Qi Wang E-mail:wqinno8751@gmail.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81870779);International Science and Technology Cooperation and Exchange Research Project of Sichuan Province(2017HH0078)

Abstract:

Diabetes mellitus is associated with alveolar bone defects during implant therapy due to the mutual influence of its systemic complications and local oral conditions, which cause osseointegration failure and pose a challenge for treatment. The treatment of such bone defects is still clinically difficult at present. However, a growing number of studies focused on the mechanism and repair methods for the bone defect. With the in-depth study of the etiology mechanism, comprehensive treatment programs are gradually improving. This paper reviewed the etiology and treatment of the alveolar bone defect in diabetic condition from both systemic and local aspects and provided new ideas for clinical treatment.

Key words: diabetes mellitus, hyperglycemia, dental implant, bone defect, osseointegration

CLC Number: 

  • R783.4

TrendMD: 
[1] Chrcanovic BR, Albrektsson T, Wennerberg A . Dia-betes and oral implant failure: a systematic review[J]. J Dent Res, 2014,93(9):859-867.
doi: 10.1177/0022034514538820
[2] Al-Sowygh ZH, Ghani SMA, Sergis K , et al. Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control[J]. Clin Implant Dent Relat Res, 2018,20(3):345-351.
doi: 10.1038/sj.bdj.2018.248
[3] Yamamoto M, Sugimoto T . Advanced glycation end products, diabetes, and bone strength[J]. Curr Osteo-poros Rep, 2016,14(6):320-326.
doi: 10.1007/s11914-016-0332-1 pmid: 27704396
[4] Meng HZ, Zhang WL, Liu F , et al. Advanced glycation end products affect osteoblast proliferation and func-tion by modulating autophagy via the receptor of advanced glycation end products/raf protein/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (RAGE/Raf/MEK/ERK) pathway[J]. J Biol Chem, 2015,290(47):28189-28199.
doi: 10.1074/jbc.M115.669499
[5] Yang X, Gandhi C, Rahman MM , et al. Age-related effects of advanced glycation end products (ages) in bone matrix on osteoclastic resorption[J]. Calcif Tissue Int, 2015,97(6):592-601.
doi: 10.1007/s00223-015-0042-1 pmid: 26204848
[6] Franceschi C, Bonafè M, Valensin S , et al. Inflamm-aging. An evolutionary perspective on immunosenes-cence[J]. Ann N Y Acad Sci, 2000,908:244-254.
[7] Kour S, Rath PC . Long noncoding RNAs in aging and age-related diseases[J]. Ageing Res Rev, 2016,26:1-21.
doi: 10.1016/j.arr.2015.12.001 pmid: 26655093
[8] Ko KI, Coimbra LS, Tian C , et al. Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism[J]. Diabetologia, 2015,58(3):633-642.
doi: 10.1007/s00125-014-3470-y pmid: 4346353
[9] Algate K, Haynes DR, Bartold PM , et al. The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes[J]. J Periodont Res, 2016,51(5):549-566.
doi: 10.1111/jre.12339 pmid: 26667183
[10] Bhatti JS, Kumar S, Vijayan M , et al. Therapeutic strategies for mitochondrial dysfunction and oxidative stress in age-related metabolic disorders[J]. Prog Mol Biol Transl Sci, 2017,146:13-46.
doi: 10.1016/B978-0-12-385071-3.00012-5 pmid: 21075325
[11] Patil VS, Patil VP, Gokhale N , et al. Chronic perio-dontitis in type 2 diabetes mellitus: oxidative stress as a common factor in periodontal tissue injury[J]. J Clin Diagn Res, 2016, 10(4): BC12-BC16.
doi: 10.7860/JCDR/2016/17350.7542 pmid: 4866088
[12] Kose O, Arabaci T, Kara A , et al. Effects of mela-tonin on oxidative stress index and alveolar bone loss in diabetic rats with periodontitis[J]. J Periodontol, 2016,87(5):e82-e90.
doi: 10.1902/jop.2016.150541 pmid: 26832833
[13] Reddy MA, Zhang EL, Natarajan R . Epigenetic me-chanisms in diabetic complications and metabolic memory[J]. Diabetologia, 2015,58(3):443-455.
doi: 10.1007/s00125-014-3462-y pmid: 25481708
[14] Gallagher KA, Joshi A, Carson WF , et al. Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes[J]. Diabetes, 2015,64(4):1420-1430.
doi: 10.2337/db14-0872 pmid: 4375075
[15] Mori K, Kitazawa R, Kondo T , et al. Diabetic osteo-penia by decreased β-catenin signaling is partly in-duced by epigenetic derepression of sFRP-4 gene[J]. PLoS One, 2014,9(7):e102797.
doi: 10.1371/journal.pone.0102797
[16] Babaev EA, Balmasova IP, Mkrtumyan AM , et al. Metagenomic analysis of gingival sulcus microbiota and pathogenesis of periodontitis associated with type 2 diabetes mellitus[J]. Bull Exp Biol Med, 2017,163(6):718-721.
doi: 10.1007/s10517-017-3888-6
[17] Preshaw PM, Alba AL, Herrera D , et al. Periodontitis and diabetes: a two-way relationship[J]. Diabeto-logia, 2012,55(1):21-31.
doi: 10.1007/s00125-011-2342-y pmid: 3228943
[18] Sonnenschein SK, Meyle J . Local inflammatory reactions in patients with diabetes and periodontitis[J]. Periodontol 2000, 2015,69(1):221-254.
doi: 10.1111/prd.12089 pmid: 26252411
[19] Pradeep AR, Agarwal E, Bajaj P , et al. 4-Hydroxy-2-nonenal, an oxidative stress marker in crevicular fluid and serum in type 2 diabetes with chronic periodon-titis[J]. Contemp Clin Dent, 2013,4(3):281-285.
doi: 10.4103/0976-237X.118342 pmid: 24124291
[20] Monje A, Catena A, Borgnakke WS . Association be- tween diabetes mellitus/hyperglycaemia and peri-im-plant diseases: systematic review and meta-analysis[J]. J Clin Periodontol, 2017,44(6):636-648.
doi: 10.1111/jcpe.12724 pmid: 28346753
[21] Javed F, Romanos GE . Impact of diabetes mellitus and glycemic control on the osseointegration of den-tal implants: a systematic literature review[J]. J Pe-riodontol, 2009,80(11):1719-1730.
doi: 10.1902/jop.2009.090283 pmid: 19905942
[22] Serrão CR, Bastos MF, Cruz DF , et al. Role of met-formin in reversing the negative impact of hyper-glycemia on bone healing around implants inserted in type 2 diabetic rats[J]. Int J Oral Maxillofac Im-plants, 2017,32(3):547-554.
doi: 10.11607/jomi.5754 pmid: 28494038
[23] Aguilar-Salvatierra A, Calvo-Guirado JL, González-Jaranay M , et al. Peri-implant evaluation of im-mediately loaded implants placed in esthetic zone in patients with diabetes mellitus type 2: a two-year study[J]. Clin Oral Implants Res, 2016,27(2):156-161.
doi: 10.1111/clr.12552 pmid: 25623884
[24] Wu YY, Yu T, Yang XY , et al. Vitamin D3 and insulin combined treatment promotes titanium implant os-seointegration in diabetes mellitus rats[J]. Bone, 2013,52(1):1-8.
doi: 10.1016/j.bone.2012.09.005 pmid: 22985888
[25] Morris HF, Ochi S, Winkler S . Implant survival in patients with type 2 diabetes: placement to 36 months[J]. Ann Periodontol, 2000,5(1):157-165.
doi: 10.1902/annals.2000.5.1.157 pmid: 11885176
[26] Schwartz-Arad D, Levin L, Sigal L . Surgical success of intraoral autogenous block onlay bone grafting for alveolar ridge augmentation[J]. Implant Dent, 2005,14(2):131-138.
doi: 10.1097/01.id.0000165031.33190.0d pmid: 15968184
[27] Tawil G, Younan R, Azar P , et al. Conventional and advanced implant treatment in the type Ⅱ diabetic patient: surgical protocol and long-term clinical re-sults[J]. Int J Oral Maxillofac Implants, 2008,23(4):744-752.
doi: 10.1016/j.ijom.2008.04.009 pmid: 18807573
[28] Erdogan ö, Uçar Y, Tatlı U , et al. A clinical prospec-tive study on alveolar bone augmentation and dental implant success in patients with type 2 diabetes[J]. Clin Oral Implants Res, 2015,26(11):1267-1275.
doi: 10.1111/clr.12450 pmid: 25041273
[29] Yu M, Zhou W, Song YL , et al. Development of mesenchymal stem cell-implant complexes by cul-tured cells sheet enhances osseointegration in type 2 diabetic rat model[J]. Bone, 2011,49(3):387-394.
doi: 10.1016/j.bone.2011.05.025 pmid: 21672646
[30] Schlegel KA, Prechtl C, Möst T , et al. Osseointe-gration of SLActive implants in diabetic pigs[J]. Clin Oral Implants Res, 2013,24(2):128-134.
doi: 10.1111/j.1600-0501.2011.02380.x pmid: 22111960
[31] Ma XY, Feng YF, Ma ZS , et al. The promotion of osteointegration under diabetic conditions using chitosan/hydroxyapatite composite coating on porous titanium surfaces[J]. Biomaterials, 2014,35(26):7259-7270.
doi: 10.1016/j.biomaterials.2014.05.028 pmid: 24912815
[32] Li X, Ma XY, Feng YF , et al. Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions[J]. Biomaterials, 2015,36:44-54.
doi: 10.1016/j.biomaterials.2014.09.012 pmid: 25308520
[33] Al Amri MD, Kellesarian SV, Al-Kheraif AA , et al. Effect of oral hygiene maintenance on HbA1c levels and peri-implant parameters around immediately-loaded dental implants placed in type-2 diabetic patients: 2 years follow-up[J]. Clin Oral Implants Res, 2016,27(11):1439-1443.
doi: 10.1111/clr.12758
[34] Figuero E, Graziani F, Sanz I , et al. Management of peri-implant mucositis and peri-implantitis[J]. Perio-dontol 2000, 2014,66(1):255-273.
doi: 10.1111/prd.12049 pmid: 25123773
[35] Wang Q, Li H, Xiao Y , et al. Locally controlled de-livery of TNFα antibody from a novel glucose-sen-sitive scaffold enhances alveolar bone healing in dia- betic conditions[J]. J Control Release, 2015,206:232-242.
doi: 10.1016/j.jconrel.2015.03.019 pmid: 25796348
[1] Han Chong,He Dongning,Yu Feiyan,Wu Dongchao. Research progress on the mechanism and treatment of pain after oral implants [J]. Int J Stomatol, 2024, 51(1): 99-106.
[2] Liao Honglin,Fang Zhonghan,Zhang Yanyan,Liu Fei,Shen Jiefei.. Diagnosis and treatment of post-traumatic trigeminal neuropathic pain after dental implantation [J]. Int J Stomatol, 2023, 50(6): 729-738.
[3] Gong Jiaming,Zhao Ruimin,Pan Hongwei,Lang Xin,Yu Zhanhai,Li Jianxue. Meta-analysis of dynamic navigation versus static navigation in the accuracy of implant surgery [J]. Int J Stomatol, 2023, 50(5): 538-551.
[4] Zhu Keshi,Liao Anqi,Yu Youcheng.. Research progress on the application of machine learning in dental implantology [J]. Int J Stomatol, 2023, 50(4): 491-498.
[5] Xu Yanxue,Fu Li.. Research progress on functionally graded membranes for guided bone regeneration [J]. Int J Stomatol, 2023, 50(3): 353-358.
[6] Lu Qian,Xia Haibin,Wang Min.. Research progress on implantoplasty in the treatment of peri-implantitis [J]. Int J Stomatol, 2023, 50(2): 152-158.
[7] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontics microsurgery: clinical protocol and practical cases (part 2) [J]. Int J Stomatol, 2022, 49(6): 621-632.
[8] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and en-dodontic diseases in aesthetic area (part 1): application basis and indications [J]. Int J Stomatol, 2022, 49(5): 497-505.
[9] Zhang Xidan,Sun Jiyu,Fu Xinliang,Gan Xueqi.. Research progress on the development of mesoporous calcium silicate nanoparticles in endodontics and repairing maxillofacial bone defects [J]. Int J Stomatol, 2022, 49(4): 476-482.
[10] Li Yanfei,Zhang Xinchun. Research progress on the dentin bone repair material [J]. Int J Stomatol, 2022, 49(2): 197-203.
[11] Wang Yue,Wen Bing,Deng Mengting,Li Jianping. Research advances of low-level laser therapy on peri-implant tissue healing [J]. Int J Stomatol, 2021, 48(6): 725-730.
[12] Guo Yuting,Lü Xuechao. Research progress on drugs regulating the osteogenic differentiation of dental pulp stem cells [J]. Int J Stomatol, 2021, 48(6): 737-744.
[13] Zhu Xuanzhi,Zhao Lei. Research progress on the relationship between hypothyroidism and periodontitis [J]. Int J Stomatol, 2021, 48(4): 380-384.
[14] Feng Lu,Meng Wenxia. Research progress on the problems of dental implant treatment in patients with common oral mucosal disease [J]. Int J Stomatol, 2021, 48(2): 147-155.
[15] Wang Jia,Li Wenxia,Yin Lihua. Restoration strategy of dental implant for impacted teeth in the edentulous area [J]. Int J Stomatol, 2021, 48(1): 77-81.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .