Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (1): 78-83.doi: 10.7518/gjkq.2019.01.014

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Research progress on oral manifestations of vitamin B12 deficiency

Yan Tao,Yu Zhou(),Qianming. Chen   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-04-16 Revised:2018-08-09 Online:2019-01-01 Published:2019-01-11
  • Contact: Yu Zhou E-mail:812471898@qq.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81470747);This study was supported by National Natural Science Foundation of China(81771086)

Abstract:

Vitamin B12 is a cobalt-containing coordination compound and is necessary for normal hematopoiesis and nervous system function. Serum vitamin B12 lower than 148 pmol·L -1 would been diagnosed as vitamin B12 deficiency. Malabsorption is the common cause of vitamin B12 deficiency. The clinical features of vitamin B12 deficiency are complicated and vary greatly in severity, with symptoms such as anaemia, neurological features and digestive system damage. However, the clinical manifestations of a few patients are mild and concealed and easy to be ignored. Early diagnosis and treatment are important to prevent neurologic signs, which could be irreversible. Oral signs and symptoms include atrophic glossitis, recurrent aphthos ulcer, oral lichen planus and burning mouth syndrome, which may occur in the absence of symptomatic anaemia or neurological features. Patients with vitamin B12 deficiency maybe first visit the department of stomatology. The aim of this review is to summarize oral manifestations of vitamin B12 deficiency, so as to facilitate early detection, diagnosis and treatment of vitamin B12 deficiency.

Key words: vitamin B12 deficiency, oral disease, manifestation

CLC Number: 

  • R781.5

TrendMD: 

Fig 1

A diagram of the diagnosis and treatment of vitamin B12 deficiency"

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