Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (6): 710-715.doi: 10.7518/gjkq.2018.06.015

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Progress of salivaomics in diagnosis of oral cancer

Qian Li,Ping Zhang,Jiao Chen,Xin Zeng,Yun Feng()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-12-29 Revised:2018-04-17 Online:2018-11-01 Published:2018-11-15
  • Contact: Yun Feng E-mail:953463551@qq.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81372892);Sichuan Province Science and Technology Innovation Team Program(JCPT2011-9)

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Abstract:

Saliva analysis has long been considered a potential alternative to blood serum and urine analyses. This body fluid is gaining popularity due to its ease of collection, safety in handling, low cost and high efficiency. Salivaomics includes six diagnostic alphabets: salivary genomics, transcriptomics, proteomics, metabolomics, microbiomics and microRNA (miRNA). Saliva contains extensive biological information, thereby playing important role in the early diagnosis of oral disorder and several systemic diseases. Direct contact between saliva and oral cancer lesions makes measurement of tumour markers in saliva an attractive alternative to serum testing. Salivaomics may offer a robust alternative for clinicians in making clinical decision in the future. This article provides an updated review on the progress of salivaomics in oral cancer diagnosis.

Key words: saliva, salivaomics, oral cancer, diagnosis

CLC Number: 

  • R333.1

TrendMD: 
[1] Wong DT . Salivaomics[J]. J Am Dent Assoc, 2012,143(10 Suppl):19S-24S.
doi: 10.14219/jada.archive.2012.0339
[2] Torre LA, Bray F, Siegel RL , et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015,65(2):87-108.
doi: 10.3322/caac.21262
[3] Cheng YS, Rees T, Wright J . A review of research on salivary biomarkers for oral cancer detection[J]. Clin Transl Med, 2014,3(1):3.
doi: 10.1186/2001-1326-3-3 pmid: 3945802
[4] Sultan ZK, Najeeb S, Khan RS , et al. Salivaomics: an emerging approach in dentistry[J]. J Pak Dent Assoc, 2016,25(2):42-43.
[5] Looi ML, Zakaria H, Osman J , et al. Quantity and quality assessment of DNA extracted from saliva and blood[J]. Clin Lab, 2012,58(3/4):307-312.
doi: 10.1515/labmed-2012-0002 pmid: 22582505
[6] Yeh CK, Christodoulides NJ, Floriano PN , et al. Current development of saliva/oral fluid-based diagnostics[J]. Tex Dent J, 2010,127(7):651-661.
pmid: 3742318
[7] Bassim CW, Ambatipudi KS, Mays JW , et al. Quan-titative salivary proteomic differences in oral chronic graft-versus-host disease[J]. J Clin Immunol, 2012,32(6):1390-1399.
doi: 10.1007/s10875-012-9738-4 pmid: 22806177
[8] Chandra A, Agnihotri A, Gupta S. Oral squamous cell carcinoma & p 53: an overview[M]. Germany: LAP LAMBERT Academic Publishing, 2013.
[9] Cova MAMN, Castagnola M, Messana I , et al. Salivary qmics[M]. Berlin: Springer, 2015: 63-82.
[10] Kim EM, Jung CH, Kim J , et al. The p53/p21 com-plex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins[J]. Cancer Res, 2017,77(11):3092-3100.
doi: 10.1158/0008-5472.CAN-16-2098 pmid: 28377455
[11] Bhatia V, Goel MM, Makker A . DNA methylation: an epigenetic mechanism in oral squamous cell car-cinoma[J]. South Asian J Exp Biol, 2014,4(2):33-41.
[12] Don KR, Ramani P, Ramshankar V , et al. Promoter hypermethylation patterns of P16, DAPK and MGMT in oral squamous cell carcinoma: a systematic review and meta-analysis[J]. Indian J Dent Res, 2014,25(6):797-805.
doi: 10.4103/0970-9290.152208 pmid: 25728117
[13] Guerrero-Preston R, Soudry E, Acero J , et al. NID2 and HOXA9 promoter hypermethylation as bio-markers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva[J]. Cancer Prev Res (Phila), 2011,4(7):1061-1072.
doi: 10.1158/1940-6207.CAPR-11-0006
[14] Righini CA, de Fraipont F, Timsit JF , et al. Tumor-specific methylation in saliva: a promising biomarker for early detection of head and neck cancer recur-rence[J]. Clin Cancer Res, 2007,13(4):1179-1185.
doi: 10.1158/1078-0432.CCR-06-2027 pmid: 17317827
[15] Nagata S, Hamada T, Yamada N , et al. Aberrant DNA methylation of tumor-related genes in oral rinse: a noninvasive method for detection of oral squamous cell carcinoma[J]. Cancer, 2012,118(17):4298-4308.
doi: 10.1002/cncr.27417 pmid: 22252571
[16] El-Naggar AK, Mao L, Staerkel G , et al. Genetic heterogeneity in saliva from patients with oral squamous carcinomas: implications in molecular diagnosis and screening[J]. J Mol Diagn, 2001,3(4):164-170.
doi: 10.1016/S1525-1578(10)60668-X
[17] Li Y, St John MA, Zhou X , et al. Salivary transcrip-tome diagnostics for oral cancer detection[J]. Clin Cancer Res, 2004,10(24):8442-8450.
doi: 10.1158/1078-0432.CCR-04-1167
[18] Brinkmann O, Kastratovic DA, Dimitrijevic MV , et al. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population[J]. Oral Oncol, 2011,47(1):51-55.
doi: 10.1016/j.oraloncology.2010.10.009
[19] Lisa Cheng YS, Jordan L, Gorugantula LM , et al. Salivary interleukin-6 and -8 in patients with oral cancer and patients with chronic oral inflammatory diseases[J]. J Periodontol, 2014,85(7):956-965.
doi: 10.1902/jop.2013.130320 pmid: 24147842
[20] Zhang X, Jung IH, Hwang YS . EGF enhances low-invasive cancer cell invasion by promoting IMP-3 expression[J]. Tumour Biol, 2016,37(2):2555-2563.
doi: 10.1007/s13277-015-4099-2 pmid: 26386725
[21] Sugimoto M, Wong DT, Hirayama A , et al. Capillary electrophoresis mass spectrometry-based saliva me-tabolomics identified oral, breast and pancreatic cancer-specific profiles[J]. Metabolomics, 2010,6(1):78-95.
doi: 10.1007/s11306-009-0178-y
[22] 及昕, 崔磊华, 张宁 , 等. 口腔鳞状细胞癌患者唾液的代谢组学分析[J]. 中国老年学, 2016,36(3):560-562.
doi: 10.3969/j.issn.1005-9202.2016.03.019
Ji X, Cui LH, Zhang N , et al. The metabolism of the saliva of oral squamous cell carcinoma patients[J]. Chin J Gerontol, 2016,36(3):560-562.
doi: 10.3969/j.issn.1005-9202.2016.03.019
[23] 张书平, 丁继芬, 李宁毅 . 唾液SA、CEA测定在口腔鳞状细胞癌诊断中的意义[J]. 现代口腔医学杂志, 2003,17(6):510-511.
doi: 10.3969/j.issn.1003-7632.2003.06.010
Zhang SP, Ding JF, Li NY . Significance of CEA and SA in saliva of patients with squamous cell carcinoma in oral and maxillofacial region[J]. J Mod Stomatol, 2003,17(6):510-511.
doi: 10.3969/j.issn.1003-7632.2003.06.010
[24] Vajaria BN, Patel KR, Begum R , et al. Evaluation of serum and salivary total sialic acid and α-l-fucosi-dase in patients with oral precancerous conditions and oral cancer[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013,115(6):764-771.
doi: 10.1016/j.oooo.2013.01.004 pmid: 23570662
[25] Whitmore SE, Lamont RJ . Oral bacteria and cancer[J]. PLoS Pathog, 2014,10(3):e1003933.
doi: 10.1371/journal.ppat.1003933
[26] Mager DL, Haffajee AD, Devlin PM , et al. The salivary microbiota as a diagnostic indicator of oral cancer: a descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma sub-jects[J]. J Transl Med, 2005,3:27.
doi: 10.1186/1479-5876-3-27 pmid: 1226180
[27] Pushalkar S, Ji X, Li Y , et al. Comparison of oral microbiota in tumor and non-tumor tissues of pa-tients with oral squamous cell carcinoma[J]. BMC Microbiol, 2012,12:144.
doi: 10.1186/1471-2180-12-144 pmid: 3507910
[28] Furquim CP, Soares GM, Ribeiro LL , et al. The sa-livary microbiome and oral cancer risk: a pilot study in Fanconi anemia[J]. J Dent Res, 2017,96(3):292-299.
doi: 10.1177/0022034516678169 pmid: 27827319
[29] Salazar C, Nagadia R, Pandit P , et al. A novel saliva-based microRNA biomarker panel to detect head and neck cancers[J]. Cell Oncol (Dordr), 2014,37(5):331-338.
doi: 10.1007/s13402-014-0188-2 pmid: 25156495
[30] Momen-Heravi F, Trachtenberg AJ, Kuo WP , et al. Genomewide study of salivary microRNAs for detection of oral cancer[J]. J Dent Res, 2014,93(7 Suppl):86S-93S.
doi: 10.1177/0022034514531018 pmid: 24718111
[31] Tasoulas J, Patsouris E, Giaginis C , et al. Salivaomics for oral diseases biomarkers detection[J]. Expert Rev Mol Diagn, 2016,16(3):285-295.
doi: 10.1586/14737159.2016.1133296
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
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[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .