Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (3): 368-372.doi: 10.7518/gjkq.2018.03.023

• Reviews • Previous Articles    

Research progress on diagnosis and treatment for submucous cleft palate

Shi Jiahong, Lu Yong   

  1. Dept. of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China
  • Received:2017-09-10 Revised:2018-02-05 Published:2018-05-08
  • Supported by:
    This study was supported by the Project of Medical Scientific Research of Health Department of Jiangsu Province (H201239) and the Project of Science and Technology Development of Nanjing (YKK15117, QRX11125).

Abstract: Submucous cleft palate (SMCP) is a special type of cleft palate, presenting the classic clinical features which are a bifid uvula, a midline transluscent zone (zonapellucida) of the soft palate, and a palpable bony notch within the posterior hard palate. Abnormal insertion of the levator palatini muscle causes velopharyngeal insufficiency (VPI), otitis media and so on. There are always late discovery of SMCP and we observed that the VPI incidence after palatoplasty for SMCP patients was higher than that of other cases of cleft palate. So much attention should be paid to SMCP. This article makes a brief summary of the pathological causes, clinical manifestations, diagnosis and treatment.

Key words: submucous cleft palate, velopharyngeal insufficiency, triad syndrome diagnosis

CLC Number: 

  • R782.2+2

TrendMD: 
[1] Weatherley-White RC, Sakura CY Jr, Brenner LD, et al.Submucous cleft palate. Its incidence, natural history, and indications for treatment[J]. Plast Re-constr Surg, 1972, 49(3):297-304.
[2] García Velasco M, Ysunza A, Hernandez X, et al.Diagnosis and treatment of submucous cleft palate: a review of 108 cases[J]. Cleft Palate J, 1988, 25(2): 171-173.
[3] Hanny KH, de Vries IA, Haverkamp SJ, et al. Late detection of cleft palate[J]. Eur J Pediatr, 2016, 175(1):71-80.
[4] Reiter R, Brosch S, Wefel H, et al.The submucous cleft palate: diagnosis and therapy[J]. Int J Pediatr Otorhinolaryngol, 2011, 75(1):85-88.
[5] Park TS, Bae YC, Nam SB, et al.Postoperative speech outcomes and complications in submucous cleft palate patients[J]. Arch Plast Surg, 2016, 43(3): 254-257.
[6] 胡晓, 李叶扬, 梁岷, 等. 维甲酸改变腭突发育关键时期细胞增殖和凋亡导致腭裂[J]. 中华整形外科杂志, 2016, 32(3):220-224.
Hu X, Li YY, Liang M, et al.Induced cleft palat by retinoic acid through altering the cell proliferation and apoptosis at the key stages of palatal development[J]. Chin J Plast Surg, 2016, 32(3):220-224.
[7] Cohen SR, Chen L, Trotman CA, et al.Soft-palate myogenesis: a developmental field paradigm[J]. Cleft Palate Craniofac J, 1993, 30(5):441-446.
[8] Stal S, Hicks MJ.Classic and occult submucous cleft palates: a histopathologic analysis[J]. Cleft Palate Craniofac J, 1998, 35(4):351-358.
[9] Reiter R, Brosch S, Lüdeke M, et al.Genetic and environmental risk factors for submucous cleft palate[J]. Eur J Oral Sci, 2012, 120(2):97-103.
[10] Funato N, Nakamura M, Richardson JA, et al.Tbx1 regulates oral epithelial adhesion and palatal deve-lopment[J]. Hum Mol Genet, 2012, 21(11):2524-2537.
[11] Calnan J.Submucous cleft palate[J]. Br J Plast Surg, 1954, 6(4):264-282.
[12] Archer K, Marrinan E, Stearns S, et al.Uvular mal-formation in the presence of deformational plagio-cephaly[J]. J Craniofac Surg, 2015, 26(3):836-839.
[13] Shprintzen RJ, Schwartz RH, Daniller A, et al.Mor-phologic significance of bifid uvula[J]. Pediatrics, 1985, 75(3):553-561.
[14] Ominato R, Kobayashi T, Kodama Y, et al.Clinical investigation of patients with submucous cleft palate: diagnosis and clinical manifestations[J]. J Japan Cleft Palate Assoc, 2016, 41(1):24-30.
[15] Oji T, Sakamoto Y, Ogata H, et al.A 25-year review of cases with submucous cleft palate[J]. Int J Pediatr Otorhinolaryngol, 2013, 77(7):1183-1185.
[16] ten Dam E, van der Heijden P, Korsten-Meijer AG, et al. Age of diagnosis and evaluation of consequences of submucous cleft palate[J]. Int J Pediatr Otorhino-laryngol, 2013, 77(6):1019-1024.
[17] Ha KM, Cleland H, Greensmith A, et al.Submucous cleft palate: an often-missed diagnosis[J]. J Craniofac Surg, 2013, 24(3):878-885.
[18] Friedman MA, Miletta N, Roe C, et al.Cleft palate, retrognathia and congenital heart disease in velo-cardio-facial syndrome: a phenotype correlation study[J]. Int J Pediatr Otorhinolaryngol, 2011, 75(9):1167-1172.
[19] Stern Y, Segal K, Yaniv E.Endoscopic adenoidec-tomy in children with submucosal cleft palate[J]. Int J Pediatr Otorhinolaryngol, 2006, 70(11):1871-1874.
[20] Mostafa E, Rezk I, Awad AH.Assessing palatal mobility in post-tonsillectomy patients[J]. Egypt J Ear Nose Throat All Sci, 2016, 17(2):71-73.
[21] Fulcher A, Purcell AA, Baker E, et al.Listen up: children with early identified hearing loss achieve age-appropriate speech/language outcomes by 3 years-of-age[J]. Int J Pediatr Otorhinolaryngol, 2012, 76(12):1785-1794.
[22] Perry JL, Kuehn DP, Wachtel JM, et al.Using magnetic resonance imaging for early assessment of submucous cleft palate: a case report[J]. Cleft Palate Craniofac J, 2012, 49(4):e35-e41.
[23] Mori Y, Hoshi K, Takato T, et al.Submucous cleft palate: variations in bony defects of the hard palate[J]. Br J Oral Maxillofac Surg, 2013, 51(8):e220-e223.
[24] Ren S, Ma L, Zhou X, et al.Bony defect of palate and vomer in submucous cleft palate patients[J]. Int J Oral Maxillofac Surg, 2015, 44(1):63-66.
[25] Sommerlad BC, Fenn C, Harland K, et al.Submucous cleft palate: a grading system and review of 40 con-secutive submucous cleft palate repairs[J]. Cleft Palate Craniofac J, 2004, 41(2):114-123.
[26] Smyth AG.Submucous cleft palate: outcomes after primary repair with repositioning of the levator muscle in 51 consecutive patients[J]. Br J Oral Maxillofac Surg, 2016, 54(5):561-567.
[27] Smyth A.Clinical grading system for submucous cleft palate[J]. Br J Oral Maxillofac Surg, 2014, 52(3):275-276.
[28] 尹恒, 郭春丽, 石冰, 等. 黏膜下腭裂的形态分类与腭咽功能分析[J]. 华西口腔医学杂志, 2016, 34(5): 488-492.
Yin H, Guo CL, Shi B, et al.Morphological classifi-cation and velopharyngeal function analysis of sub-mucous cleft palate patients[J]. West Chin J Stomatol, 2016, 34(5):488-492.
[29] McWilliams BJ. Submucous clefts of the palate: how likely are they to be symptomatic[J]. Cleft Palate Cra-niofac J, 1991, 28(3):247-251.
[30] Shah S, Garg R, Uppal SK, et al.Sub mucous cleft palate with fenestration[J]. Int J Appl Basic Med Res, 2014, 4(Suppl 1):S56-S57.
[31] 屈文静, 尹宁北. 隐性腭裂手术治疗进展[J]. 中国美容医学, 2012, 21(9):1659-1662.
Qu WJ, Yin NB.Surgical treatment progress of submucous cleft palate[J]. Chin J Aesth Med, 2012, 21(9):1659-1662.
[1] Zhang Yuning,Zeng Ni,Zhang Bei,Shi Bing,Zheng Qian.. A preliminary study of the effect of posterior pharyngeal flap surgery on the maxillofacial growth of patients after palatoplasty [J]. Int J Stomatol, 2023, 50(1): 66-71.
[2] Huang Hanyao, Wang Mengjiao, Wu Hao, Jiang Liping, Zhang Wenjing, Wei Shan, Yin Heng. Reliability and validity of the velopharyngeal insufficiency effects on life outcomes instrument [J]. Inter J Stomatol, 2018, 45(2): 177-184.
[3] Cao Congcong, Li Jingtao, Zheng Qian. Research progress on craniofacial growth and development of patients with submucous cleft palate [J]. Inter J Stomatol, 2017, 44(4): 390-392.
[4] Li Sheng, Jiang Hongbing, Wan Linzhong, Yuan Hua, Wang Binbing, Jiang Chenghui, Du Yifei.. Individual treatment of velopharygeal incomplete after palatoplasty [J]. Inter J Stomatol, 2016, 43(6): 640-644.
[5] CHEN Xiao-rong1, ZHAO Biao1, YIN Heng2. . The charactristics of speech training for postoperation cleft palate patients who have marginal velopharyngeal insufficiency after palatoplasty [J]. Inter J Stomatol, 2011, 38(3): 279-282.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .