Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (3): 276-279.doi: 10.7518/gjkq.2018.03.006

• Stem Cell • Previous Articles     Next Articles

Immune regulation of dental stem cells

Zhang Xiangyi, Liu Yali   

  1. Dept. of Orthodontics, Stomatological Hospital of Kunming Medical University, Kunming 650032, China
  • Received:2017-04-08 Revised:2017-10-12 Published:2018-05-08
  • Supported by:
    This study was supported by National Natural Science Foundation of China (31301067), Research Fund of The Ministry of Education’s Doctoral Programs (20135317120005) and Yunnan Provincial Education Department Scientific Research Fund (2013Z106).

RichHTML

16

PDF (PC)

412

Abstract: Dental stem cell (DSC) is a type of stem cells that possess unique immunomodulation properties and can be effectively obtained from isolated dental or periodontal tissue. They exert immunosuppressive effects through direct contact or secretion of cytokines and play a key role in the proliferation, differentiation, and apoptosis of T cells, B cells, and other lymphocytes. The treatment of a variety of chronic inflammatory and autoimmune diseases has a certain clinical significance. In this review, we summarize current studies on the immunomodulatory properties of several common DSCs.

Key words: dental stem cell, immunomodulation, stem cell therapy

CLC Number: 

  • R392

TrendMD: 
[1] Seo BM, Miura M, Gronthos S, et al.Investigation of multipotent postnatal stem cells from human periodontal ligament[J]. Lancet, 2004, 364(9429): 149-155.
[2] Gronthos S, Mankani M, Brahim J, et al.Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo[J]. Proc Natl Acad Sci USA, 2000, 97(25): 13625-13630.
[3] Sonoyama W, Liu Y, Fang D, et al.Mesenchymal stem cell-mediated functional tooth regeneration in swine[J]. PLoS One, 2006, 1:e79.
[4] Sonoyama W, Liu Y, Yamaza T, et al.Characteriza-tion of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study[J]. J Endod, 2008, 34(2):166-171.
[5] Zhang Q, Shi S, Liu Y, et al.Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflam-mation-related tissue destruction in experimental colitis[J]. J Immunol, 2009, 183(12):7787-7798.
[6] Miura M, Gronthos S, Zhao M, et al.SHED: stem cells from human exfoliated deciduous teeth[J]. Proc Natl Acad Sci USA, 2003, 100(10):5807-5812.
[7] Ulmer FL, Winkel A, Kohorst P, et al.Stem cells—prospects in dentistry[J]. Schweiz Monatsschr Za-hnmed, 2010, 120(10):860-883.
[8] Wada N, Menicanin D, Shi S, et al.Immunomodula-tory properties of human periodontal ligament stem cells[J]. J Cell Physiol, 2009, 219(3):667-676.
[9] Yamaza T, Kentaro A, Chen C, et al.Immunomo-dulatory properties of stem cells from human ex-foliated deciduous teeth[J]. Stem Cell Res Ther, 2010, 1(1):5.
[10] Shimono M, Ishikawa T, Ishikawa H, et al.Regula-tory mechanisms of periodontal regeneration[J]. Microsc Res Tech, 2003, 60(5):491-502.
[11] Kim HS, Kim KH, Kim SH, et al.Immunomodula-tory effect of canine periodontal ligament stem cells on allogenic and xenogenic peripheral blood mono-nuclear cells[J]. J Periodontal Implant Sci, 2010, 40(6):265-270.
[12] Ding G, Liu Y, Wang W, et al.Allogeneic perio-dontal ligament stem cell therapy for periodontitis in swine[J]. Stem Cells, 2010, 28(10):1829-1838.
[13] 申琳. 静压力作用下牙周膜干细胞介导大鼠T淋巴细胞凋亡的研究[D]. 西安: 第四军医大学, 2015.
Shen L.The study of PDLSCs-mediated T cell apo-ptosis under the static pressure[D]. Xi’an: The Fourth Military Medical University, 2015.
[14] Vasandan AB, Shankar SR, Prasad P, et al.Func-tional differences in mesenchymal stromal cells from human dental pulp and periodontal ligament[J]. J Cell Mol Med, 2014, 18(2):344-354.
[15] Liu D, Xu J, Liu O, et al.Mesenchymal stem cells derived from inflamed periodontal ligaments exhibit impaired immunomodulation[J]. J Clin Periodontol, 2012, 39(12):1174-1182.
[16] Liu O, Xu J, Ding G, et al.Periodontal ligament stem cells regulate B lymphocyte function via programmed cell death protein 1[J]. Stem Cells, 2013, 31(7):1371-1382.
[17] Ding G, Niu J, Liu Y.Dental pulp stem cells sup-press the proliferation of lymphocytes via transfor-ming growth factor-β1[J]. Hum Cell, 2015, 28(2):81-90.
[18] Iwasaki A, Medzhitov R.Toll-like receptor control of the adaptive immune responses[J]. Nat Immunol, 2004, 5(10):987-995.
[19] Zhao Y, Wang L, Jin Y, et al.Fas ligand regulates the immunomodulatory properties of dental pulp stem cells[J]. J Dent Res, 2012, 91(10):948-954.
[20] 郭俊, 杨建. 人牙根尖乳头干细胞及其在组织工程中的研究进展[J]. 国际口腔医学杂志, 2010, 37(4):464-466.
Guo J, Yang J.Research progress on stem cells from the apical papilla and its application in tissue en-gineering[J]. Int J Stomatol, 2010, 37(4):464-466.
[21] Ding G, Liu Y, An Y, et al.Suppression of T cell proliferation by root apical papilla stem cells in vitro [J]. Cells Tissues Organs, 2010, 191(5):357-364.
[22] Liu C, Xiong H, Chen K, et al.Long-term exposure to pro-inflammatory cytokines inhibits the osteo-genic/dentinogenic differentiation of stem cells from the apical papilla[J]. Int Endod J, 2016, 49(10):950-959.
[23] Cao Y, Xia DS, Qi SR, et al.Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways[J]. Cell Prolif, 2013, 46(4):447-456.
[24] Zhang QZ, Su WR, Shi SH, et al.Human gingiva-derived mesenchymal stem cells elicit polarization of 2 macrophages and enhance cutaneous wound healing[J]. Stem Cells, 2010, 28(10):1856-1868.
[25] Su WR, Zhang QZ, Shi SH, et al.Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms[J]. Stem Cells, 2011, 29(11):1849-1860.
[26] 宋芳, 邹慧儒. 牙源干细胞在再生医学中的应用[J]. 国际口腔医学杂志, 2013, 40(2):224-228.
Song F, Zhou HR.Application of dental stem cells in tissue regeneration[J]. Int J Stomatol, 2013, 40(2): 224-228.
[27] Yildirim S, Zibandeh N, Genc D, et al.The comparison of the immunologic properties of stem cells isolated from human exfoliated deciduous teeth, dental pulp, and dental follicles[J]. Stem Cells Int, 2016. DOI: 10.1155/2016/4682875.
[1] Li Pei,Lin Ling,Zhao Wei.. Research progress on the stem cells from human exfoliated deciduous teeth in the regeneration and repair of oral tissue [J]. Int J Stomatol, 2022, 49(4): 483-488.
[2] Cai Yunzhu,Zhu Shu,Liu Yao,Chen Xu.. Research progress on dental stem cells in the treatment of nervous system diseases [J]. Int J Stomatol, 2022, 49(3): 255-262.
[3] Song Fang, Zou Huiru.. Application of dental stem cells in tissue regeneration [J]. Inter J Stomatol, 2013, 40(2): 224-228.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .