Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (6): 619-627.doi: 10.7518/gjkq.2017.06.001

• Expert Forum •     Next Articles

Oral microbiome in the precision medicine

Xu Xin, He Jinzhi, Zhou Xuedong.   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontis, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-06-09 Revised:2017-07-13 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81670978, 81600874), Key Project for Frontier Research of Science and Technology Department of Sichuan Province(2016JY0006), and Clinical Innovation Grant of West China Hospital of Stomatology, Sichuan University(LCXJS2015-3).

Abstract: Modern medicine has shifted from “disease oriented” to “patient oriented” and has consequently created a new era of personalized medicine or precision medicine. The physiological functions of the human body are determined not only by the human genome but also by symbiotic microflora. Currently, studies on the human microbiome have extended from a simple analysis of the association of bacteria and diseases to a complex analysis of the role of microbiome in the pathogenesis, diagnosis, and treatment of diseases. These breakthroughs possibly promote the practice of personalized/precision medicine. This review summarizes the advances in oral microbiome-related research. In particular, the potential role of oral microbiome in the risk prediction, diagnosis, treatment evaluation, and prognosis of diseases is extensively discussed. Current challenges in the development of oral microbiome-based precision medicine are also described.

Key words: oral microbiome, precision medicine, omics, precise risk prediction, precise diagnosis, precise therapy, precise evaluation

CLC Number: 

  • R37

TrendMD: 
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