Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (2): 200-203.doi: 10.7518/gjkq.2017.02.017

• Reviews • Previous Articles     Next Articles

Clinical parameters and risk factors of pregnancy gingivitis

Wu Xinyu, Cai Qiaoyi, Zhou Yikun, Zou Yong   

  1. 1. The State Key Laboratory Breeding Base of Basic Science of StomatologyHubei-MOST & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatolgy, Wuhan University, Wuhan 430079, China;
    2. Wuhan Medical Emergency Center, Wuhan 430000, China
  • Received:2016-02-08 Online:2017-03-01 Published:2017-03-01
  • Supported by:
    This study was supported by the Planning Project of Innovation and Enterpreneurship Training of Undergraduate of Wuhan University(S2014841).

Abstract: Gingivitis can increase the risk of adverse pregnancy, which leads to premature delivery, abortion, and low newborn bodyweight. During pregnancy, gingival index and periodontal pocket depth increase, whereas bleeding on probing doesnot show asignificant increase. The change of clinical attachment loss has not been clear. Plaque index shows less fluctuation and keeps at a low level during pregnancy and after delivery. The plasma concentration of the sex hormone in pregnant women is 10 times as much as that of non-pregnant women. The high plasma concentration of the sex hormone can increase the production of inflammation mediators, such as dinoprostone and interleukin(IL)-6, which increase the degree of inflammatory response. The treatment of pregnancy gingivitis faces more challenges than ordinary gingivitis because of a special systematic condition. Precautions include promoting oral hygiene and instructing pregnant women to keep good oral health to reduce the incidence rate. Clinicians can be provided with references on how to relieve and eliminate gingivitis symptoms and guarantee pregnant women and their baby’s health by exploring the occurrence and development of pregnancy gingivitis.

Key words: pregnancy gingivitis, sex hormone, microbe, cytokine

CLC Number: 

  • R781.4+1

TrendMD: 
[1] Jain K, Kaur H. Prevalence of oral lesions and mea-surement of salivary pH in the different trimesters of pregnancy[J]. Singapore Med J, 2015, 56(1):53-57.
[2] Borgo PV, Rodrigues VAA, Feitosa ACR, et al. As-sociation between periodontal condition and subgin-gival microbiota in women during pregnancy: a lon-gitudinal study[J]. J Appl Oral Sci, 2014, 22(6):528- 533.
[3] Machado FC, Cesar DE, Assis AV, et al. Detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women[J]. Braz Oral Res, 2012, 26(5):443-449.
[4] Figuero E, Carrillo-de-Albornoz A, Herrera D, et al. Gingival changes during pregnancy:Ⅰ. Influence of hormonal variations on clinical and immunological parameters[J]. J Clin Periodontol, 2010, 37(3):220- 229.
[5] Carrillo-de-Albornoz A, Figuero E, Herrera D, et al. Gingival changes during pregnancy: Ⅱ. Influence of hormonal variations on the subgingival biofilm[J]. J Clin Periodontol, 2010, 37(3):230-240.
[6] Carrillo-de-Albornoz A, Figuero E, Herrera D, et al. Gingival changes during pregnancy: Ⅲ. Impact of clinical, microbiological, immunological and socio-demographic factors on gingival inflammation[J]. J Clin Periodontol, 2012, 39(3):272-283.
[7] Han YW, Fardini Y, Chen C, et al. Term stillbirth caused by oral Fusobacterium nucleatum [J]. Obstet Gynecol, 2010, 115(2 Pt 2):442-445.
[8] Yokoyama M, Hinode D, Yoshioka M, et al. Rela-tionship between Campylobacter rectus and perio-dontal status during pregnancy[J]. Oral Microbiol Immunol, 2008, 23(1):55-59.
[9] Usin MM, Tabares SM, Parodi RJ, et al. Periodontal conditions during the pregnancy associated with periodontal pathogens[J]. J Investig Clin Dent, 2013, 4(1):54-59.
[10] Bhardwaj A, Bhardwaj SV. Effect of menopause on women’s periodontium[J]. J Midlife Health, 2012, 3 (1):5-9.
[11] McKnight H, Kelsey WP, Hooper DA, et al. Pro-teomic analyses of human gingival and periodontal ligament fibroblasts[J]. J Periodontol, 2014, 85(6): 810-818.
[12] Fteita D, Könönen E, Söderling E, et al. Effect of estradiol on planktonic growth, coaggregation, and biofilm formation of the Prevotella intermedia group bacteria[J]. Anaerobe, 2014, 27:7-13.
[13] Nebel D, Bratthall G, Ekblad E, et al. Estrogen re-gulates DNA synthesis in human gingival epithelial cells displaying strong estrogen receptor β immuno- reactivity[J]. J Periodont Res, 2011, 46(5):622-628.
[14] Reynolds MA, Aberdeen GW, Pepe GJ, et al. Estro-gen suppression induces papillary gingival over-growth in pregnant baboons[J]. J Periodontol, 2004, 75(5):693-701.
[15] Fujii S, Fujimoto K, Goto N, et al. Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells[J]. Biomed Rep, 2015, 3(4):566- 572.
[16] Jiang SY, Xue D, Xie YF, et al. The negative feed back regulation of microRNA-146a in human perio-dontal ligament cells after Porphyromonas gingivalis lipopolysaccharide stimulation[J]. Inflamm Res, 2015, 64(6):441-451.
[17] Nebel D, Arvidsson J, Lillqvist J, et al. Differential effects of LPS from Escherichia coli and Porphy - romonas gingivalis on IL-6 production in human periodontal ligament cells[J]. Acta Odontol Scand, 2013, 71(3/4):892-898.
[18] Andrukhov O, Ertlschweiger S, Moritz A, et al. Different effects of P. gingivalis LPS and E. coli LPS on the expression of interleukin-6 in human gingival fibroblasts[J]. Acta Odontol Scand, 2014, 72(5):337-345.
[19] Jitprasertwong P, Chaisomboon N, Jamdee K. Pro-gesterone, but not β-estradiol, enhances Porphyro - monas gingivalis lipopolysaccharide-induced vas-cular endothelial growth factor-A expression in human THP-1 monocytes[J]. J Dent Sci, 2013, 8(4): 358-364.
[20] Bieri RA, Adriaens L, Spörri S, et al. Gingival fluid cytokine expression and subgingival bacterial counts during pregnancy and postpartum: a case series[J]. Clin Oral Investig, 2013, 17(1):19-28.
[1] Cheng Yifan,Qin Xu,Jiang Ming,Zhu Guang-xun.. Research progress on innate lymphoid cells in periodontal diseases [J]. Int J Stomatol, 2023, 50(1): 32-36.
[2] Zhou Jianpeng,Xie Xudong,Zhao Lei,Wang Jun.. Research progress on the roles and mechanisms of T-helper 17 cells and interleukin-17 in periodontitis [J]. Int J Stomatol, 2022, 49(5): 586-592.
[3] Zhou Tingru,Li Yongsheng. Advances of dental pulp stem cells in osteogenic microenvironment [J]. Int J Stomatol, 2019, 46(6): 675-679.
[4] Jiang Yiyang,Liu Yi. Effects of methylation on the occurrence and development of periodontitis and its clinical application [J]. Int J Stomatol, 2019, 46(5): 593-603.
[5] Zhuo Yang,Shengdan Zhang,Chengcheng Liu,Yi Ding. Research progress on salivary markers for diagnosis of aggressive periodontitis [J]. Inter J Stomatol, 2019, 46(1): 55-61.
[6] Li Yihan, Pan Lanlan. Correlation between periodontal diseases and Alzheimer’s disease [J]. Inter J Stomatol, 2018, 45(3): 335-339.
[7] Zhang Peng, Ding Yi, Wang Qi. Research on the role of inflammaging in diabetes mellitus-associated periodontitis [J]. Inter J Stomatol, 2017, 44(6): 664-668.
[8] Li Xinyi, Dong Wei. Enamel matrix protein in enhancing periodontal tissue regeneration [J]. Inter J Stomatol, 2015, 42(5): 600-605.
[9] Sun Zhixin, Zhang Yuntao. Correlation studies on peri-implantitis and interleukin [J]. Inter J Stomatol, 2015, 42(2): 221-224.
[10] Wang Jianqi, Xu Lihua. Helper T cells and its balance and periodontitis [J]. Inter J Stomatol, 2015, 42(2): 225-230.
[11] Meng Qingyang, Zheng Rong, Zhu Yang, Wang Dandan, Wu Lipeng, Sun Hongchen. Osteoclast differentiation factors and their signaling pathways [J]. Inter J Stomatol, 2015, 42(2): 189-193.
[12] Guo Tianqi, Zhou Yanmin, Zhao Jinghui, Chu Shunli, Sun Qianyue, Luo Wenjing, Ma Shanshan. Platelet-rich fibrin and other biological materials used jointly for periodontal tissue repair [J]. Inter J Stomatol, 2015, 42(2): 231-236.
[13] Fan Jian, Zou Gengsen, Chen Jiang. Immune response of the body to nanomodified titanium implant surfaces [J]. Inter J Stomatol, 2014, 41(6): 691-693.
[14] Zhu Qian, Cai Ping. Effects of estrogen on cytokines related to bone remodeling in orthodontic treatment [J]. Inter J Stomatol, 2014, 41(6): 694-698.
[15] Luo Wenjing, Zhao Jinghui, Ma Shanshan, Sun Qianyue, Guo Tianqi, Zhou Yanmin.. Biological composition and function of platelet-rich fibrin [J]. Inter J Stomatol, 2014, 41(4): 448-454.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .