Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (6): 685-689.doi: 10.7518/gjkq.2016.06.015

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Biological functions of microRNA-203 and its role in oral diseases

Geng Fengxue, Pan Yaping.   

  1. Dept. of Periodontology, The Affiliated Hospital of Stomatology, China Medical University, Shenyang 110002, China
  • Online:2016-11-01 Published:2016-11-01

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Abstract: MicroRNA-203(miR-203) plays important roles in the development and progression of tumor and inflammation by targeting and regulating various downstream mediators at different levels. MiR-203 is a novel diagnostic and prognostic marker because of its therapeutic potential. The intensive investigation of mechanism in tumor development within micro-environment of inflammation has made the potent role of miR-203 in regulating inflammation-related tumor a new controversial issue. Recently, the regulatory mechanisms of miR-203 have been investigated in oral diseases. This mini-review focuses on the biological function of miR-203, especially its role in oral diseases.

Key words: microRNA-203, tumor, inflammation, tumor suppressor gene, inflammation micro-environment


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