Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (5): 609-613.doi: 10.7518/gjkq.2016.05.025

Previous Articles     Next Articles

Effect of gingipains on osteoclasts and osteoblasts

Hou Yubo1, Liu Xinchan2, Yu Haiyan1, Cui Leihua3, Yu Weixian4   

  1. 1. Dept. of Periodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China; 2. Dept. of Implantation, Hospital of Stomatology, Jilin University, Changchun 130021, China; 3. Dept. of Oral and Maxillofacial Surgery, Jilin University, Changchun 130021, China; 4. Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China
  • Received:2015-12-07 Revised:2016-05-30 Online:2016-09-01 Published:2016-09-01

RichHTML

7

PDF (PC)

466

Abstract: Gingipains are cysteine proteases produced by Porphyromonas gingivalis, one of the major virulent agents of periodontal diseases. On the one hand, gingipains promote the differentiation of osteoclasts to enhance osteoclast function by activating the osteoprotegerin(OPG)/receptor activator of nuclear factor-κB(NF-κB) ligand(RANKL)/receptor activator of the NF-κB signaling pathways through degradation of OPG and induction of RANKL. On the other hand, gingipains inhibit osteoblast function by inducing osteoblast apoptosis through the external pathway mediated by the tumor necrosis factor receptor family and the mitochondrial pathway. These effects eventually lead to alveolar bone loss. This paper presents recent progress on gingipains and their effects on the functions of osteoclasts and osteoblasts.

Key words: Porphyromonas gingivalis, periodontitis, gingipains, osteoclasts, osteoblasts

CLC Number: 

  • Q 51

TrendMD: 
[1] Fu Yu, He Wei, Huang Lan. Ferroptosis and its implication in oral diseases [J]. Int J Stomatol, 2024, 51(1): 36-44.
[2] Luo Xiaojie,Wang Dexu,Chen Xiaotao. Relationship between periodontitis and ferroptosis based on bioinformatics analysis [J]. Int J Stomatol, 2023, 50(6): 661-668.
[3] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[4] Hu Jia,Wang Xiuqing,Lu Guoying,Huang Xiaojing.. Regenerative endodontic procedures for permanent tooth with immature apices in adult patients [J]. Int J Stomatol, 2023, 50(6): 686-695.
[5] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[6] Xu Zhibo,Meng Xiuping.. Research progress on mechanism of Enterococcus faecalis escaping host immune defense [J]. Int J Stomatol, 2023, 50(5): 613-617.
[7] Sun Jia,Han Ye,Hou Jianxia. Research progress on the role of interleukin-6-hepcidin signal axis in regulating the pathogenesis of periodontitis-associated anemia [J]. Int J Stomatol, 2023, 50(3): 329-334.
[8] Liang Zhiying,Zhao Yuanxi,Zhu Jiani,Su Qin.. Retrospective analysis of clinical data of 288 cases of endodontic microsurgery on anterior teeth [J]. Int J Stomatol, 2023, 50(2): 166-171.
[9] Liu Tiqian,Liang Xing,Liu Weiqing,Li Xiaohong,Zhu Rui.. Research progress on the role and mechanism of occlusal trauma in the development of periodontitis [J]. Int J Stomatol, 2023, 50(1): 19-24.
[10] Li Qiong,Yu Weixian. Research progress on resveratrol for the treatment of periodontitis and its bioavailability [J]. Int J Stomatol, 2023, 50(1): 25-31.
[11] Huang Weikun,Xu Qiuyan,Zhou Ting.. Role of baicalin and mechanisms through which baicalin attenuates oxidative stress injury induced by lipopolysaccharide on macrophages [J]. Int J Stomatol, 2022, 49(5): 521-528.
[12] Zhou Jianpeng,Xie Xudong,Zhao Lei,Wang Jun.. Research progress on the roles and mechanisms of T-helper 17 cells and interleukin-17 in periodontitis [J]. Int J Stomatol, 2022, 49(5): 586-592.
[13] Chen Huiyu,Bai Mingru,Ye Ling.. Progress in understanding the correlations between semaphorin 3A and common oral diseases [J]. Int J Stomatol, 2022, 49(5): 593-599.
[14] Wang Guanru,Feng Qiang.. Research progress on the role of Porphyromonas gingivalis on promoting the development of Alzheimer ’ s disease [J]. Int J Stomatol, 2022, 49(4): 397-403.
[15] Zhou Jiajia,Zhao Lei,Xu Xin. Research progress on the genetic polymorphism of periodontitis [J]. Int J Stomatol, 2022, 49(4): 432-440.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .