Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (3): 333-337.doi: 10.7518/gjkq.2016.03.018

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Effect of sclerostin on cementogenesis and its mechanism

Chen Tian, Bai Ding   

  1. State Key Laboratory of Oral Diseases, Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) This study was supported by the National Natural Science Foundation of China(11172190, 81371171) and the Doctoral Program Foundation of Institution of Higher Education of China(20130181110013).
  • Received:2015-07-10 Revised:2016-01-15 Online:2016-05-01 Published:2016-05-01

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Abstract: Sclerostin, a secreted glycoprotein with a C-terminal cysteine knot-like domain protein, is produced by the osteocytes and has anti-anabolic effects on bone formation. Sclerostin is an antagonist of Wnt signaling pathway by binding to low density lipoprotein receptor-related protein-5/6 receptors and prompting the phosphorylation of β-catenin. Cementum is a specialized substance covering the root of a tooth and a dynamic entity within the periodontium sustaining the firmness of the tooth. Sclerostin has been identified during cementogenesis, in which the underlying mechanism is still obscure. On this basis, providing a comprehensive insight into the interactional and reciprocal molecular mechanism between sclerostin and cementum may facilitate cementogenesis-related tooth development and regeneration.

Key words: cementum, sclerostin, wingless-type mice mammary tumour virus integration site family-β-catenin-signal transduction pathway, molecular mechanism, mineralized tissues, cementum, sclerostin, wingless-type mice mammary tumour virus integration site family-β-catenin-signal transduction pathway, molecular mechanism, mineralized tissues

CLC Number: 

  • Q 51

TrendMD: 
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