Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (3): 344-347.doi: 10.7518/gjkq.2015.03.023

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The occurrence and development of complement and periodontitis and its treatment

Li Na1, Gao Aichao1, Wang Lili2, Yu Haiyan2, Yu Weixian1,2   

  1. 1. Dept. of Periodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China; 2. Remodeling and Regeneration of Provincial Key Laboratory of Development of Tooth and Jaw, School of Stomatology, Jilin University, Changchun 130021, China
  • Received:2014-08-31 Revised:2015-02-13 Online:2015-05-01 Published:2015-05-01

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Abstract:

The complement system mediates the body’s defense reactions to protect the host against periodontal chronic inflammatory diseases. This system assists pathogens to exacerbate pathological and destructive inflammation by directly affecting immune cells or via crosstalk and by regulating other host signaling pathways. The complement system induces secretion of interleukin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor during immune inflammation. Secretion is stimulated by activating leukocytes, regulating helper T cells and macrophages, and promoting cell immune and T cell-dependent antibody secretion, thus enhancing the regulation of immune effect and improving the body’s immunity. Furthermore, the complement system produces inflammation that exacerbates tissue damage and triggers periodontitis. The antagonists of the complement receptor can significantly clean pathogens and prevent periodontitis by interfering the signaling crosstalk between the complement receptor and Toll-like receptors. Therefore, elucidating the mechanism of the complement system in periodontitis can provide novel targets for periodontitis therapeutics.

Key words: periodontitis, immune inflammation, complement

CLC Number: 

  • R 781.4+2

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