Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (4): 444-447.doi: 10.7518/gjkq.2014.04.018

Previous Articles     Next Articles

Innate immune effect and its expression level in oral tissues of follicular dendritic cells secreted protein

Tao Chuansibo, Mei Fang, Zhong Jinsheng.   

  1. School of Stomatology, Peking University, Beijing 100191, China
  • Received:2013-05-02 Revised:2014-01-24 Online:2014-07-01 Published:2014-07-01

RichHTML

6

PDF (PC)

2499

Abstract:

Follicular dendritic cell secretory protein(FDC-SP) is a protein generated by a follicular dendritic cell. FDCSP can bind to the surface of B cells whose gene lies on chromosome 4q13 adjacent to the clusters of proline-rich salivary peptides. Cysteine-X-Cysteine chemokine, which is adjacent to chromosome 4 open reading frame 7, not only regulates the antibody response and B cell chemotaxis but is also involved in the innate immune response. FDC-SP is expressed in the light zone of germinal-center leukocyte-infiltrated tonsil crypts by lipopolysaccharide(LPS), Staphylococcus aureus Cowan strain 1-activated leukocytes, or junctional epithelium in the oral cavity. FDC-SP is therefore significant in oral innate immunity. In addition, FDC-SP positively affects the proliferation of periodontal ligament cells and inhibits their differentiation into the mineralized tissue cells of fibroblasts through the epidermal growth factor receptor signal transduction pathway. As a specific biomarker of junctional epithelium in oral innate immunity, the expression of FDCSP is closely related to LPS level. Reports suggest that the periodontal health status and progress of periodontitis can be determined by the location or quantification of FDC-SP.

Key words: follicular dendritic cell-secreted protein, biomarkers, innate immunity, periodontal health

CLC Number: 

  • Q 51

TrendMD: 
[1] Yang Qianjuan,Song Zhixin,Fang Shishu,Gu Zexu,Jin Zuolin,Liu Qian. New advances in oral diseases based on salivary metabolomics [J]. Int J Stomatol, 2023, 50(3): 321-328.
[2] Yu Shuxing,Zou Jing,Li Yuqing. Advances in saliva-based detection of viral infectious biomarkers [J]. Int J Stomatol, 2022, 49(2): 189-196.
[3] Zhu Jinyi,Fan Qi,Zhou Yuan,Zou Jing,Huang Ruijie. Research progress of salivary proteins as predictive biomarkers for early childhood caries [J]. Int J Stomatol, 2022, 49(2): 212-219.
[4] Cao Zhengguo. Periodontal considerations in prosthetic dentistry [J]. Int J Stomatol, 2022, 49(1): 1-11.
[5] Shujuan Guo, Qian Liu, Yi Ding. A brief introduction of the new classification scheme for periodontal and peri-implant diseases and conditions [J]. Int J Stomatol, 2019, 46(2): 125-134.
[6] Sun Han, Hou Xu, Yu Wenwen, Qi Jia, Liu Jiming, Lou Yixin, Sun Xinhua.. Advancement of the role of Toll-like receptors in bone reconstruction [J]. Inter J Stomatol, 2015, 42(4): 450-452.
[7] Jiang Lan, Song Zhi, Lin Zhengmei.. Nucleotide-binding oligomerization domain protein and its expression in dental pulp [J]. Inter J Stomatol, 2013, 40(5): 678-682.
[8] Su Lingkai, Fan Mingwen.. The role of tumor necrosis factor receptor -associated factor nuclear factor -κB-binding kinase 1 and stimulator of interferon genes mediated immune responses to DNA vaccines [J]. Inter J Stomatol, 2012, 39(5): 672-674.
[9] Su Ruiying1，2, Chen Shanshan1，2, Zhao Lei2.. Antimicrobial peptide LL-37 and its relationship between periodontal disease [J]. Inter J Stomatol, 2012, 39(3): 324-327.
[10] ZHANG Li, LIN Zheng-mei. Research progress of innate immunity-associated cells in dental pulp [J]. Inter J Stomatol, 2009, 36(6): 675-678.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .