Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (6): 751-755.doi: 10.3969/j.issn.1673-5749.2012.06.014

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Research progress on transcription factor families regulating mandibular development

Chen Yanze1, Shi Ce1, Sun Hongchen1, Lin Chongtao2.   

  1. 1. Dept. of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China; 2. Dept. of Periodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2011-08-18 Revised:2012-07-31 Online:2012-11-01 Published:2012-11-01

Abstract:

The development of vertebrate mandible involves a series of signaling molecules and transcription factors. The migration, orientation and regulation of the cranial neural crest cell(CNCC) are the key to mandibular development. The transcription factor families play an essential role in the development of mandible and their expression partly determines the specificity of CNCC. In this review, researches on DLX, MSX, OTX, GSC, PITX, PAX, PRX, BARX, HAND and other transcription factor families involved in regulation of mandibular development were reviewed.

Key words: mandible, development, regulation, transcription factor


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