Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (6): 646-648.doi: 10.3969/j.issn.1673-5749.2011.06.007

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Influence of Nimesulide on expression of ang-2 gene in human tongue squamous cell carcinoma Tca8113

Wang Xiaoyan1, Wu Yunxia2.   

  1. 1. Dept. of Stomatology, Otolaryngology Branch, Longgang District Central Hospital of Shenzhen, Shenzhen 518172, China; 2. Dept. of Stomatology, The Affiliated First Hospital of Shanxi Medical University,Taiyuan 030001, China
  • Received:2010-08-28 Revised:2011-08-31 Online:2011-11-20 Published:2011-11-20

Abstract:

Objective To investigate the influence of Nimesulide(NIM), a selective cyclo-oxygenase(COX)-2 inhibitor, on angiogenins(ang) gene expressions in human tongue squamous cell carcinoma Tca8113. Methods Tca8113 cells were treated with NIM(25, 50, 100, 200 μmol•L-1) for 48 h to meaure the expression of ang-2 mRNA in Tca8113 cells by the semiquantitative reverse transcription polymerase chain reaction analysis. Results The expression of ang-2 mRNA reduced in a concentration dependent manner. Conclusion NIM can down-regulate ang-2 gene expression, which may be involved in cancer angiogenesis inhibition mechanisms of COX-2 inhibitor.

Key words: tongue squamous cell carcinoma, cyclo-oxygenase, angiogenesis, angiogenin


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