Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (1): 7-9.doi: 10.3969/j.issn.1673-5749.2011.01.002

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Expression of vascular endothelial growth factor-C in squamous cell carcinoma of the tongue with dif

 FENG  Zheng-Hu, LI  Chun-Qing, WANG  Ling, HAN  Bing, NIE  Hong-Bing, SU  Xue-Lian   

  1. Key Laboratory of Stomatology of State Ethnic Affairs Commission, Northwest University for Nationalities, Lanzhou 730030, China; Dept. of Stomatology, Medical College of Northwest University for Nationalities, Lanzhou 730030, China
  • Received:2010-08-02 Revised:2010-09-10 Online:2011-01-20 Published:2011-01-20

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Abstract:

Objective  To study the vascular endothelial growth factor（VEGF）-C expression in squamous cell carcinoma of the tongue with different pattern of invasion. Methods  39 cases with squamous cell carcinoma of the tongue were classified into four groups according to the pattern of invasion described by Anneroth and VEGFC expression was detected respectively by using immunohistochemical staining. Results  The expression of VEGFC in tumor cells varied from the pattern of invasion. The expression in squamous cell carcinoma of the tongue with pattern Ⅲ and Ⅳ of invasion had a high lever than that of pattern Ⅰand Ⅱ. The clinical findings showed that the rate of lymph node metastasis was easily involved in pattern Ⅲ and Ⅳ of invasion. Conclusion VEGFC is correlated with pattern of invasion and it may play an important role in invasion and regional lymph node metastasis in squamous cell carcinoma of the tongue.

Key words: vascular endothelial growth factor -C, pattern of invasion, squamous cell carcinoma of the tongue, immunohistochemistry

CLC Number: 

  • Q 51

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