Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (02): 166-166～169.doi: 10.3969/j.issn.1673-5749.2010.02.012

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Molecular regulation mechanism of Nel-like type 1 molecule to the osteoblast diff

ZHOU Haihua1, LI Zu-bing2   

  1. 1. The State Key Laboratory Breeding Base of Basic Science of Stomatology（Hubei-
  • Received:2009-05-18 Revised:2009-10-16 Online:2010-03-20 Published:2010-03-20
  • Contact: LI Zu-bing

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Abstract: Nel-like type 1 molecule（Nell-1） is one of the novel growth factors with important biological function on the differentiation and apoptosis of osteoblasts. This review emphasized on the gene expression cascades between nell-1 and transforming growth factor or fibroblast growth factor, the signal regulation mechanisms and associated molecular signal pathways of nell-1 regulating the differentiation of osteoblasts. The effect of Nell-1 regulating the extracellular matrix（ECM） proteins that are necessary in osteogenesis and chondrogenesis has also been discussed.

Key words: Nel-like type 1 molecule, osteoblast, cell differentiation, regulation mechanism

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