国际口腔医学杂志

国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 228-232.doi: 10.7518/gjkq.2016.02.025

• 综述 • 上一篇    下一篇

丙氨酸消旋酶的研究进展

邱伟,周学东,李明云   

  1. 口腔疾病研究国家重点实验室 华西口腔医院（四川大学） 成都 610041
  • 收稿日期:2015-07-22 修回日期:2015-12-08 出版日期:2016-03-01 发布日期:2016-03-01
  • 通讯作者: 李明云，讲师，博士，Email：limingyun@scu.edu.cn
  • 作者简介:邱伟，硕士，Email：787498084@qq.com
  • 基金资助:
    国家自然科学基金青年科学基金（81400501）；口腔疾病 研究国家重点实验室专项经费（SKLOD201525）

Research progress on alanine racemase

Qiu Wei, Zhou Xuedong, Li Mingyun   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
  • Received:2015-07-22 Revised:2015-12-08 Online:2016-03-01 Published:2016-03-01

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摘要： 丙氨酸消旋酶（ALR）是以吡哆醛磷酸为辅酶，催化L-丙氨酸与D-丙氨酸相互转化的一类酶，广泛分布于低等生物，与由细菌引起的疾病密切相关。近年来ALR已成为设计抗菌药物的又一理想靶位。变异链球菌是口腔龋病主要致病菌，产酸耐酸、黏附能力和合成细胞内外多糖能力是其主要的致龋毒力。本文对ALR的分类、结构特征、生理功能及实际应用等方面进行系统阐述，为进一步研究ALR与变异链球菌致病毒力的关系，发展龋病抗菌药物候选靶标提供理论基础。

关键词: 丙氨酸消旋酶, 致龋毒力, 生理功能, 丙氨酸消旋酶, 致龋毒力, 生理功能

Abstract: Alanine racemase(ALR) is a pyridoxal phosphate-dependent enzyme that catalyzes reversible racemization between enantiomers of alanine. The enzyme is widely used/existed in lower organisms and is closely related to diseases caused by bacteria. In recent years, ALR has become an ideal design target of antibacterial drugs. Streptococcus mutans(S. mutans) is the main pathogenic bacteria in dental caries, and the main cariogenic virulence of S.mutans includes acid production, ability of adhesion and synthesis of polysaccharide. This review will systematically summarize the classifications, structure characteristics, physiological function, and application of ALR. A comprehensive understanding of the relationship between ALR and cariogenic virulence of S.mutans is useful and can provide an important theoretical basis for additional research on the potential antibacterial drug target to caries.

Key words: alanine racemase, cariogenecities, physiological function, alanine racemase, cariogenecities, physiological function

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