国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 705-710.doi: 10.7518/gjkq.2019104

• 综述 • 上一篇    下一篇

白色念珠菌影响口腔黏膜癌变的机制进展

文书琼,郭君怡,戴文晓,王迪侃,王智()   

  1. 中山大学光华口腔医学院? 附属口腔医院黏膜科 广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2019-02-24 修回日期:2019-05-16 出版日期:2019-11-01 发布日期:2019-11-14
  • 通讯作者: 王智
  • 作者简介:文书琼,博士,Email： wenshq@mail2.sysu.edu.cn
  • 基金资助:
    国家自然科学基金(81772896)

Research progress on the mechanism of Candida albicans in oral carcinogenesis

Wen Shuqiong,Guo Junyi,Dai Wenxiao,Wang Dikan,Wang Zhi()   

  1. Guanghua School of Stomatology, Dept. of Oral Medicine, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2019-02-24 Revised:2019-05-16 Online:2019-11-01 Published:2019-11-14
  • Contact: Zhi Wang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81772896)

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摘要：

微生物感染是癌症发生的重要因素,目前,越来越多的研究支持这样的观点：机会性白色念珠菌通过患者的免疫抑制状态,增加患者患癌的概率和肿瘤转移的风险。最近的研究结果表明,白色念珠菌可能通过以下几种机制来促进癌症发生：产生致癌副产物、引发炎症以及诱导辅助性T细胞17反应。本文就白色念珠菌影响口腔黏膜癌变机制的研究进展作一综述,以期能够进一步阐明白色念珠菌和癌症发生之间的关系,有望为预防和治疗口腔黏膜癌变提供新思路。

关键词: 白色念珠菌, 致癌物质, 癌变, 炎症, 辅助性T细胞17免疫反应

Abstract:

Microbial infection is one of the important causes of carcinogenesis. To date, an increasing number of researches have indicated that Candida albicans can increase the patients’ risk of carcinogenesis and tumor metastasis through the immunosuppressive state. Recent studies have demonstrated that Candida albicans promote the carcinogenesis through several mechanisms such as producing carcinogenic byproducts, triggering inflammation and inducing T helper cell 17 response. Here, we provide an overview of the research progress of oncogenic potential of Candida albicans and discuss the relationship between Candida albicans and cancer, trying to provide new ideas for the prevention and treatment of oral cancer.

Key words: Candida albicans, carcinogen, carcinogenesis, inflammation, T helper cell 17 immune response

中图分类号: 

  • R781.5 +4

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