国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (5): 609-616.doi: 10.7518/gjkq.2019057

• 综述 • 上一篇    下一篇

口腔慢性移植物抗宿主病的研究进展

周雨曦,雍翔智,江巧芝,陶人川()   

  1. 广西艾滋病防治研究重点实验室 南宁 530021
  • 收稿日期:2018-11-17 修回日期:2019-05-26 出版日期:2019-09-01 发布日期:2019-09-10
  • 通讯作者: 陶人川
  • 作者简介:周雨曦,硕士,Email： zhouyuxichn@163.com
  • 基金资助:
    国家自然科学基金(81771073);广西自然科学基金(2015GXNSFDA139018)

Oral chronic graft versus host disease

Zhou Yuxi,Yong Xiangzhi,Jiang Qiaozhi,Tao Renchuan()   

  1. Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning 530021, China
  • Received:2018-11-17 Revised:2019-05-26 Online:2019-09-01 Published:2019-09-10
  • Contact: Renchuan Tao
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81771073);Natural Science Foundation of Guangxi Province(2015GXNSFDA139018)

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摘要：

慢性移植物抗宿主病（cGVHD）是一种表现为自身免疫性疾病样的综合征,口腔是其最为常见的受累器官之一。口腔病损可以独立存在,称之为口腔cGVHD,常常表现为口腔黏膜的慢性炎症和唾液腺纤维性病变。及时有效的诊治口腔cGVHD有助于减少患者痛苦,提高其生活质量。但目前对口腔cGVHD发病机制了解并不确切,本文将就口腔cGVHD的临床、病理表现、发病机制和治疗等的研究进展进行综述。

关键词: 口腔慢性移植物抗宿主病, 临床表现, 病理表现, 发病机制, 治疗

Abstract:

Chronic graft versus host disease (cGVHD) is a syndrome that manifests as an autoimmune disease. Oral lesions, called oral cGVHD, can exist independently and often present as chronic inflammation of the oral mucosa and salivary gland fibrosis. Timely and effective diagnosis and treatment of oral cGVHD can help reduce the suffering of patients and improve their quality of life. However, current understanding of oral cGVHD pathogenesis is limited. This review focuses on the progress of the clinical manifestations, pathological manifestations, pathogenesis, and treatment of oral cGVHD.

Key words: oral chronic graft versus host disease, clinical manifestations, pathological manifestations, pathogenesis, treatment

中图分类号: 

  • R781.5 +9

表 1

cGVHD患者口腔表征评分表"

口腔黏膜的改变 轻度 计分 中度 计分 重度 计分
红斑 轻度或中度红斑样改变（<25%） 1 中度（≥25%）或重度（<25%）红斑样改变 2 重度红斑样改变（≥25%） 3
苔藓样变 苔藓样变（<25%） 1 苔藓样变（25%~50%） 2 苔藓样变（>50%） 3
溃疡 无 0 溃疡（<20%） 3 严重溃疡（>20%） 6
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