国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (5): 552-557.doi: 10.7518/gjkq.2019053

• 综述 • 上一篇    下一篇

金属-有机骨架及其复合材料在生物医学领域中的研究进展

蒋晓鸽1,吴家馨1,裴锡波2()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院 成都 610041
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院修复科 成都 610041
  • 收稿日期:2018-09-20 修回日期:2019-04-17 出版日期:2019-09-01 发布日期:2019-09-10
  • 通讯作者: 裴锡波
  • 作者简介:蒋晓鸽,学士,Email： 1623113557@qq.com
  • 基金资助:
    国家自然科学基金(81601613);四川大学人才培养平台专项建设项目(SCUKG015)

Research progress on metal-organic frameworks and their complex in biomedical field

Jiang Xiaoge1,Wu Jiaxin1,Pei Xibo2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-09-20 Revised:2019-04-17 Online:2019-09-01 Published:2019-09-10
  • Contact: Xibo Pei
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81601613);Talent Training Platform Special Construction Project of Sichuan University(SCUKG015)

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摘要：

金属-有机骨架（MOF）也被称为配位聚合物,是一种新型的有机-无机杂化晶态多孔材料,由金属离子或者金属离子簇作为节点,多配位点的有机配体作为连接点,通过配位作用自组装形成高度规则的网状骨架结构。MOF及复合材料的特殊性能促进其在生物医学领域的应用,包括种植体表面涂层改性、药物载体、储存气体、辅助生物体内显影成像等。本文对MOF材料在生物医学领域以上几个方面应用的研究情况进行综述。

关键词: 金属-有机骨架, 改性, 载药, 储气, 显影成像

Abstract:

Metal-organic frameworks (MOFs), also known as coordination polymers, is a new type of organic-inorganic hybrid crystalline porous materials. It is composed of a metal ion or metal ion cluster as the node and a polydentate organic ligand as the join point. The regular network skeleton structure is formed by their self-assembly. The special property of MOFs and their complex promotes their applications in biomedicine. The research directions at present include implant surface coating modification, drug loading, gas storage and imaging. The review of the literature attempts to address the application of MOFs in biomedicine.

Key words: metal-organic framework, modification, drug delivery, gas storage, imaging

中图分类号: 

  • R783.1
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